Chinese medicinal compound stops formation of cysts in polycystic kidney disease in lab
...disease like human polycystic kidney disease, used triptolide with a less toxic concentration than that used in cancer chemotherapy trials. At that level, the compound marked reduced cyst formation in the mice compared to genetically similar mice not taking the compound. During normal kidney development, cel......-immune diseases. Crews and colleagues showed that triptolide causes cell growth arrest in certain cell types. ... School of Medicine, who discovered the PKD2 gene, triptolide was tested in a mouse model of PKD. Both fewer and smaller kidney cysts formed in mice lacking PKD1...