Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...s that underlie aberrant NF-κB activity in MM tumor cells and underscores the relevance of the NF-κB signaling pathway as a target for MM therapy. MM is a cancer of the plasma cell, a blood cell that produces antibodies to help the body fight off infections. Previous research implicates abnorma......ors with tendrils that extend far from the primary tumor site, rendering conventional therapies ineffective...nd compared invasive cells (which left the primary tumor site) to noninvasive cells (which remained at the site of injection) in order to understand the mole...Newly created cancer stem cells could aid breast cancer research
...says pathologist Tan Ince. Each cancer cell in the tumor plays a specific role, and just a fraction of the ...xperiments, a few tissue slices revealed a primary tumor structure that resembled that of cancer patients with metastases. That prompted Ince to wonder whe...ESF EURYI award winner aims to stop cancer cells reading their own DNA
...uroHORCS). Dekker and her team are trying to stop tumor development by interfering with the molecular moto...herapy, providing it is possible to single out the tumor cells. Most existing chemotherapy targets all dividing cells, and the aim to find more sensitive te...JCI table of contents: Aug. 9, 2007
...tudies in mice indicate that the protein PU.1 is a tumor suppressor. Mice lacking a specific portion of the DNA (known as the upstream regulatory element; URE) that controls the level of expression of the PU.1 gene develop acute myeloid leukemia (AML). When researchers from Harvard Medical School, Boston, ...New test improves detection of liver cancer
...− a success rate that equals that of the AFP tumor marker currently being used in the clinic. Promising results When the AFP test is used in combination with the new test, the accuracy of HCC diagnosis rises dramatically. The new test succeeds in detecting liver cancer in more than half of the pa...Weizmann Institute scientists discover a control mechanism for metastasis
...is when cancer cells dissociate from the original tumor and migrate via the blood stream to colonize dista...tion. Next, the scientists carried out tests on tumor samples taken from around 300 patients with inflammatory breast cancer, a rare but swift and deadly ...Other highlights in the Aug. 7 JNCI
...ture of noncancerous lung tissue and corresponding tumor tissue in lung [cancer] predicts metastasis and di... progression. These findings suggest that the lung tumor and its surrounding lung environment interact, the authors write. Contact: National Cancer Instit...High-intensity ultrasound may launch attack on cancer, wherever it lurks
....C. -- An intense form of ultrasound that shakes a tumor until its cells start to leak can trigger an alarm... that just shakes the cells. That shaking ruptures tumor cell membranes, causing them to spill their contents. The toxic spill then alerts the immune system ...American Chemical Society's Weekly PressPac -- Aug. 1, 2007
...rd individualized treatments selected according to tumor cell type and patients predicted responses to different kinds of anti-cancer drugs. Their paper describes key features of state-of-the-art proteomic profiling, in which blood tests are used to analyze single proteins and multiple fingerprint protein ...Defects in critical gene lead to accelerated lung tumor growth
... out of control. Only a few of these genes called tumor suppressors are currently known. Now scientists...cal School have added to the list another powerful tumor suppressor, a gene called LKB1. Their research indicates that this gene is mutated in almost a quart......mage, we may be able to use this knowledge to make tumor cells easier to kill. Repair centers in mammalian cells are probably an efficient way to repair the typically sparse and noncomplex DNA damages of daily cellular life." But there's a downside, Costes says. "Humans didn't evolve with cosmic rays, a...Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
...rone to breaking. The site lies in the middle of a tumor suppressor gene and chromosome breakage in this ar...ssociated with cancer. "It is an area that has a tumor suppressor gene a gene whose absence can cause tumors," explained Freudenreich. "If you delete that...Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
...tic colorectal cancer patients in the study showed tumor shrinkage, classified as complete or partial respo...that the modified virus enters cells, produces the tumor protein and stimulates the immune system, said lead study author Richard Harrop, Ph.D., vice preside...U-M researchers find family of 'on switches' that cause prostate cancer
... gene fusion is involved in an individual patients tumor could impact treatment options. If an androgen-regulated gene is involved, androgen therapy would be appropriate. But if the gene fusion involves a gene that represses androgen, the anti-androgen therapy could encourage the cancers growth. This may a...Molecule blocks gene, sheds light on liver cancer
...invade other tissues, all of which are features of tumor formation. Patel and his collaborators began the study by measuring the relative levels of 197 microRNAs in normal liver cells and in liver cancer cells from human tumors and in four liver cancer cell lines. Levels of miR-21 were up to nine tim...Caffeine and exercise can team up to prevent skin cancer
... involved in killing DNA-damaged cells and p53, a tumor suppressor. The differences between the groups in the formation of UVB-induced apoptotic cells those cells derailed from the track leading to skin cancer were quite dramatic, Conney said. Compared to the UVB-exposed control animals, the caffei...A friendly foe -- Bacteria residing in the gut boost immune response to tumors
...ove the ability of tumor-specific T cells to cause tumor regression. In a study appearing online on July 26...ce, lymphodepletion does not fully account for the tumor regression observed following TBI. They show that a disruption of the population of bacteria that no...JCI table of contents -- July 26, 2007
...ove the ability of tumor-specific T cells to cause tumor regression. In a study appearing online on July 26...ce, lymphodepletion does not fully account for the tumor regression observed following TBI. They show that a disruption of the population of bacteria that no......researchers found that the gene, FOXP3, suppresses tumor growth. FOXP3 is located on the X chromosome, which means a single mutation can effectively silence the gene. This is unusual, as only one other gene linked to cancer has been found on the X chromosome. When one copy of the FOXP3 gene is silenced,...