American Chemical Society's Weekly PressPac -- June 27/July 3, 2007
...bstacle course and into the tumor. Once inside the tumor cell, the compounds convert from an inactive form ...rters for the platinum warhead, carrying it to the tumor cell and then releasing the platinum as an active drug. In one experiment with cultured cells, the S...Researchers discover method for identifying how cancer evades the immune system
One of the fundamental traits of a tumor how it avoids the immune system might become its...for determining which genes have been altered in a tumor to allow it to evade the bodys natural defenses. In time, the researchers believe such analysis coul...JCI Table of Contents -- July 2, 2007
...potentially lethal disease. Mutations in the p53 tumor suppressor gene have been implicated in tumor formation: some give rise to a loss-of-function whereas the majority of mutations result in a gain-o...p53 gene mutations and inflammation trigger skin cancer
...potentially lethal disease. Mutations in the p53 tumor suppressor gene have been implicated in tumor formation: some give rise to a loss-of-function whereas the majority of mutations result in a gain-o...M. D. Anderson team identifies new oncogene for brain cancer
...chers tried a combination of Akt and IGFBP2 and no tumor formed, suggesting that the two genes lie in the same molecular pathway and have a similar effect. For oligodendroglioma, the researchers found that IGFBP2 combined with platelet-derived growth factor beta (PDGFB) results in a higher-grade form o...Breast cancer prognosis runs in the family
...next step will be to understand what is inherited; tumor biology, response to therapy or vigilance of the immune system. ...Loss of cell's 'antenna' linked to cancer's development
...has a role in controlling normal cell movement and tumor cell invasion. Golemis laboratory has also shown that Aurora A and HEF1 interact to initiate mitosis (chromosome separation) during cell division. Suggestively, many cancers produce too much of the Aurora A protein, including breast and colorectal...Scientists discover role of enzyme in DNA repair
...uch genetic abnormalities, cell transformation and tumor development. Although its too soon to say whether these laboratory discoveries will translate into clinical use, Casellas is enthused about the work. With this new technology we can visualize for the first time the interplay between complex mechanism...Damon Runyon names new class of rising stars in cancer research
...igating the role of gene gates or nuclear pores in tumor formation and cancer progression. Lea A. Goentor...monly mutated gene in human cancer, contributes to tumor formation and aging processes. Lszl Krti, PhD, with his sponsor Elias James Corey, PhD, at Harvard U...Sentinel lymph node biopsy is associated with breast cancer rates
... lymph node biopsies often detect small numbers of tumor cells that do not necessarily indicate that the cancer has spread. While the use of [sentinel lymph node biopsy] in community practice continues to increase, it is expected that cases with [lymph node] metastases also will continue to increase, the...Nanoparticles carry chemotherapy drug deeper into solid tumors
... sometimes decreased the drugs ability to kill the tumor cells. Using a new drug carrier, Ning Tang of the ...emy of Sciences in Beijing and colleagues compared tumor growth and survival in mice that were given doxorubicin in the nanocarriers or on its own. Doxoru...Story ideas from Molecular & Cellular Proteomics
...this protein has been linked to the development of tumor cells and resistance to cancer therapy, but how it works is not well understood. Pending questions include how this protein is expressed in normal and cancer cells, how it helps cancer cells escape ionizing radiation and chemotherapy, and which patie...Omega-3 fatty acids protect eyes against retinopathy, study finds
...ors suppress a type of inflammatory protein called tumor necrosis factor alpha (TNF-alpha). TNF-alpha is found in one type of cell, called microglia, that can be closely associated with retinal blood vessels. The retina has one of the highest concentrations of omega-3 fatty acids in the body, said lead ...Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
...above 180. While CA 19-9 is a well established tumor marker for pancreatic cancer, he notes, These results allow us to stratify individuals for other therapies. If a person is operated on and has potentially curative surgery, but four to six weeks after surgery has a CA 19-9 level above 180, he or she ...Neuroblastoma expert reviews progress and challenges in fighting difficult pediatric cancer
...hood cancer deaths. It typically occurs as a solid tumor in the abdomen, but also in the neck, chest, and pelvis, developing in the network of the body's sympathetic nervous system. Neuroblastoma is what physicians call a heterogeneous disease; its name includes subtypes of disease that behave very diffe...Weill Cornell team identifies potential new cancer drug target
...mical cascade called the NF-kappa B pathway causes tumor cells to sidestep apoptosis and become dangerously immortal. "So, drug development aimed at short-circuiting NF-kappa B has become very hot in the past few years," Dr. Wu says. Her team focused on a particular protein involved in the NF-kappa B ...Mathematics reveals genetic pattern of tumor growth
...s can alter their own genetic makeup to accelerate tumor growth. The discovery shows for the first time why...c Wan looked at cancer from the point of view of a tumor and asked: What can a tumor do to optimize its own growth" They focused on the phenomenon of genetic...New $1.16 million study investigates how dietary iron is used by cells
...d iron-loading, is thought to increase the risk of tumor development, infection, cardiomyopathy, joint disorders and several endocrine and neurodegenerative disorders. And third, we now have an increasingly sophisticated knowledge and understanding of iron metabolic pathways, the proteins involved in the...JCI table of contents: June 21, 2007
...d diet high in omega-3 fatty acid reduced prostate tumor growth and increased survival in these animals, wh...turase, which converts omega-6 to omega-3, reduced tumor growth in a manner similar to the omega-3 rich diet. The researchers went on to show that the effect...Researchers pit novel version of common virus against cancer
.... So far, they are proving to be effective only in tumor cells that express certain proteins. The Rochester group designed an entirely new version of the adenovirus that might have broader, more powerful potential. The first experiments will be on pancreatic cancer, one of the deadliest malignancies. Our...