Scripps research scientists show protein accelerates breast cancer progression in animal models
...trophin activated surrounding cells to remodel the tumor microenvironment, induced tumor angiogenesis, and increased the number of receptors for different markers of aggressive breast cance...How 'memory' T cells curb the spread of viruses throughout the body
...is research may help develop vaccines that prevent tumor metastases....Cancer stem cells similar to normal stem cells can thwart anti-cancer agents
...inate a small reservoir of multiple-drug-resistant tumor cells, called cancer stem cells, which ultimately ...g resistance transporters, even if the bulk of the tumor responded to chemotherapy. According to Dr. Donnenberg, the very fact that cancers can and do rela...CSHL scientists successfully target tumor microenvironment to stop cancer growth
...(EPCs) play a critical role in the early stages of tumor progression and that eliminating EPCs stops cancer... research on how vascular progenitor cells control tumor growth and underscore their potential for cancer therapeutics. Published on June 15, 2007 in Genes ...Hot on the TRAIL of controlling inflammation in bacterial meningitis
...of the excessive immune response to infection. The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has been previously reported to play a role in the regulation of the host immune response. In the current study, Joerg Weber and colleagues administered components of Streptococcus pneumoniae ...University of Pittsburgh researchers culture blood-forming stem cells from human fat tissue
...these cells are contaminated with the patients own tumor cells. Since it has been shown in some cases that tumor cells contaminating bone marrow grafts are the source of recurrent malignancies after autologous tra...Cytokine resistance contributes to pathology of type 2 diabetes
...ctions within the cell. Interleukins, interferons, tumor necrosis factors and some growth factors are among the cytokines that direct many aspects of the immune response. Cytokines are secreted by many types of cells, including the immune cells known as macrophages. In earlier studies, the researchers ha...JCI table of contents: June 14, 2007
...of the excessive immune response to infection. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been previously reported to play a role in the regulation of the host immune response. In the current study, Joerg Weber and colleagues administered components of Streptococcus pneumoniae ...Screening approach leads to discovery of gene linked to breast cancer
...n could offer an effective therapy for women whose tumor cells harbor the mutation. The three-stage approach to finding breast cancer genes may be used in other forms of cancer as well, Hahn continues. "Our study provides a framework for integrated genomic methods of oncogene discovery."...UVa-led team uncovers important secret in gene replication
...ncy that comes from both copies being active. If tumor suppressor genes, the ones that turn off cancer cells, reside in areas of the genome with asynchronous replication, the cancer cell can turn such genes off merely by mutating the one active copy instead of going through the trouble of separately muta...Other highlights in JNCI, June 12
...forme, the most aggressive form of a type of brain tumor called glioma. The median survival for patients... a greater risk of developing glioma and increased tumor growth, whereas suppression of the gene was associated with the inhibition of tumor growth. Our ...NIH awards nearly $21 million to fund cutting-edge research equipment
...the sites of DNA damage, proteins that function as tumor suppressors and their mutants, and enzymes involved in antibiotic resistance, among others. University of Maryland Biotechnology Institute (Baltimore, Md.) $737,850.A high-speed system for confocal fluorescence imaging, subcellular photolysis, an...Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
...the ability to predict whether or not a particular tumor will respond to treatment. Resistance to chemot...ession of COL4A3BP was increased in drug-resistant tumor cells and in a small cohort of ovarian cancers following paclitaxel treatment. The researchers su...U-M researchers discover gene switched off in cancer can be turned on
...on to the next, and even the cells within a single tumor are not the same. Giving a single drug or drug combination to 500 people is setting ourselves up for failure, much like a one-size-fits-all clothing store would never succeed, Reisman says. Targeted therapies are now opening the door, because they...Tumor vessels identified by unique molecular markers
... to disrupt the growing blood vessels that support tumor growth. However, current vascular-targeted therapi...led 13 genes that are selectively overexpressed in tumor blood vessels. Although the function of most of the newly identified genes in tumor blood vessels is...Researchers shed light on mechanism of action used by anti-cancer drug
... Oncogenes are typically responsible for promoting tumor growth. Previous findings by Grants team, reported in the Journal of Biologic Chemistry, showed that in human leukemia cells, sorafenib lethality was less a consequence of Raf inhibition, but rather reflected interference with the synthesis of Mcl-...Cancer stem cells can go it alone
...l of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for sci...avior of cancer stem cells and their role in solid tumor formation at the single cell level, says lead author Ileana Zucchi, Ph.D., a molecular cancer biolog...Migration alert -- How tumor cells home in on the lymphatic system
...has published a new mechanistic description of how tumor cells migrate to the lymphatic system in the early stages of tumor metastasis. This new understanding holds significant potential for developing anti-metastasis therap...Now playing -- Cell migration LIVE!
...sse to an open wound or cancer cells detach from a tumor to metastasize....UCLA researchers discover novel pathway that may promote immune system balance
...pathogenic infections and can be mobilized to kill tumor cells. This discovery offers a strategy that will ...cancer, the immune system can be mobilized to kill tumor cells, for example, the development of anti-tumor vaccines. In this case, a drug deactivating the PI...