Researchers discover inherited mutation for leukemia
...f genes that control cell growth, and that lead to tumor growth. "Our findings identify for the first time a gene that appears to be associated with hereditary CLL," says coauthor John C. Byrd, professor of internal medicine and a CLL specialist. "They also show the importance of the gene in the path...Common cancer gene sends death order to tiny killer
...o miR-34a. "With no p53 gene or miR-34a to stem tumor development, there's no brake in pancreatic cells and uncontrolled growth leads to cancer," says Anirban Maitra, M.B.B.S., associate professor of pathology, oncology and genetic medicine. Mendell and his team are looking for missing miR-34a in othe...New mouse model closely mimics human cancers
...mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma. The comparisons showed that genetic instability in the mouse cancer cells caused DNA alterations that in many cases were identical to such changes in human tu...Tiny genes may increase cancer susceptibility, Jefferson scientists find
...hat MiRNAs are expressed have been used to profile tumor types in humans. To see if miRNAs could affect ...sting that miRNAs could be "a new family of cancer tumor susceptibility genes." Susceptibility loci are forms of the same gene. While one form may give a ...Stem cells may look malignant, not act it
...as participating in these cancers," Cogle said. "A tumor consists of a mixed bag of cells, not just one sol...bor the characteristic internal genetic defects of tumor cells. Some patients who undergo bone marrow transplant later develop secondary cancers because of...A close-up on pancreatic disease: How do we improve the odds?
...ologists often use the size of a discovered cystic tumor as a parameter for their treatment decisions; the ...reatic cancer (PC) is with surgical removal of the tumor during pancreaticoduodenectomy (PD). To determine if patients are candidates for surgery, physician...News tips from the Journal of Neuroscience
... mutations in TSC1 and TSC2 , genes that encode tumor suppressor proteins. Cortical tubers in the brain parenchyma, a pathological hallmark of the disease, contain enlarged, dysplastic neurons, accompanied by neurological symptoms including seizures and developmental delay. In this weeks Journal , Meik...Study identifying alteration in gene associated with uterine cancer
...me-scanning technology to sequence 187 endometrial tumor samples. The research team identified mutations in... a collaboration with Dr. Goodfellow, who provided tumor samples representative of the different types of uterine cancers, as well as a wealth of expertise o...Decoding gene expression in cancer tumors using noninvasive imaging
...ay allow physicians to view a CT image of a cancer tumor and discern its genetic activity. The study, desi...doctors obtain the molecular details of a specific tumor or disease without having to do an invasive biopsy procedure, will be published online on May 21 in ...Chemotherapy drug shrinks brain tumors
...o the drug. They also had more months without the tumor developing than those with the gene and were less likely to die during the study. "Our findings are consistent with previous smaller studies showing temozolomide as a primary treatment is effective and tolerable, and an added benefit is the discove...Combining NSAIDs with chemotherapy, radiation may improve cancer treatment
... drug together with radiation might provide better tumor control than radiation alone. Because inflammation is thought to play a role in the development of certain cancers, numerous studies have investigated the role of nonsteroidal anti-inflammatory drugs in cancer prevention. However, few studies have ...Role of autophagy in tumorigenesis
...ory roles of autophagy as both a cell survival and tumor suppressor pathway. Using cells that were genetica...monstrated that although loss of autophagy reduces tumor cell survival during starvation, the concurrent genome instability could accelerate tumor progressio...Effect on breast tumors of DNA alternations in 3 genes described
...icopathological features of breast cancer, such as tumor size, histological grade or nuclear grade. "Our data suggested that promoter hypermethylation is common in breast cancer," Tao added. "Because promoter hypermethylation is potentially reversible, identifying cancers with different hypermethylation ...Soy estrogens and breast cancer: Researcher offers overview
...estrogen receptors in cells, including some breast tumor cells. Dozens of studies of the role of human an...f an estrogen-responsive tumor, the growth of this tumor will be stimulated," he said. Today Helferich is most concerned about the use of genistein and oth...Pediatric cancer stem cell identified: understanding the origin of ERMS
...ving rise to other cancer cells, and thereby drive tumor growth and metastasis. To prevent recurrence and progression, effective long-term therapies must target the self-renewing population of cancer stem cells. The zebrafish is ideally suited for use in targeted chemical genetic approaches to specifical...Other highlights in the May 16 JNCI
... "Data from gene expression profiling from other tumor sites also suggest that FLIP overexpression is associated with an increased mortality in patients with prostate, breast, and lung cancers. Thus, these results raise the possibility that FLIP is a potential target for novel anticancer therapies," the ...Gene thought to assist chemo may help cancer thrive
...he cancer cells damaged by chemotherapy leading to tumor recurrence and explaining the higher mortality rate of patients whose tumors had a functioning p53. If we are correct, inhibiting p53 in tumors being treated with chemotherapy may substantially improve patients' long-term survival." McDonald and co...Burroughs Wellcome Fund awards $14M to support physician-scientists
...ic implications of genome instability during brain tumor progression Arlene Dent, M.D., Ph.D. Case Western Reserve University Acquisition of immunity to blood stage Falciparum malaria in infants Mahalia Sabrina Desruisseaux, M.D. Albert Einstein College of Medicine of Yeshiva University Neuroparasi...UF scientists identify cancer virus' genetic targets
... to influence growth of blood vessels and suppress tumor cells. Scientists believe that with the regulatory... and the UF Genetics Institute. "We think that the tumor virus is using microRNAs to make sure infected cells are well nourished and protected from the human...Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
...portant for establishing a better understanding of tumor development," said Robb Krumlauf, Ph.D., Scientific Director. "Genomic instability and gross chromosomal rearrangements are a hallmark of cancer cells. The mechanisms that initiate and drive these events are only poorly understood, but it is widely a...