Tag: "tumorigenic" at biology news
Newly discovered protein suggests novel tumorigenic pathway
... This discovery suggests the possibility of a new tumorigenic
pathway that is due to defects in a protein involv...g instability in PTEN. This would represent a new tumorigenic
pathway that is not due to a defective PTEN gene but rather a loss of PTEN function caused by PICT-1...
The Bcl-2 family tree
...s to trigger the killing of damaged cells, such as tumorigenic
ones," explains Dr. Huang....
Tumor suppressor activity of PTEN
...isease patient, is not only at risk for additional tumorigenic
mutations, but may also experience accelerated growth of tumors due to enhanced angiogenesis. Moreover, the PTEN/PI3K pathway in endothelial cells is an attractive therapeutic target for the treatment of various malignancies....
...bnormalities or differences in the rate of induced tumorigenic
potential, but RhoC-deficient mice do display markedly less tumor metastasis, compared to their wild-type littermates. Preliminary results suggest that in RhoC deficient mice, the tumor cells have less motility (thus reduce the probability of cancer...
JCI table of contents November, 2005
...uman tumors. Using E1A, an early gene product of tumorigenic
adenovirus, which transforms cells in culture and forces terminally differentiated cells to re-enter the cell cycle, the authors identified a transcriptional signature in myotubes, then dissected the mechanisms responsible for activating the individu...
Targeting pancreatic cancer
... well as a key downstream target that mediates the tumorigenic
roles of these three cathepsins. Dr. Joyce and colleagues found that E-cadherin (a known inhibitor of tumor invasion) is a target substrate of cathepsins B, L and S but not cathepsin C. Their evidence suggests that cathepsins B, L and S promote panc...
JCI table of contents: December 7, 2006
...s increased their ability to proliferate and their tumorigenic
potential. The cells from many breast cancer patients express the receptor for the hormone estrogen, and antiestrogen drugs such as tamoxifen are used to limit the growth of cancer cells in these patients. In this study, decreasing the expression of ...
JCI table of contents -- January 11, 2006
...f the protein, and inhibition of TACE impaired the tumorigenic
potential of the breast cancer cell line. Importantly, high levels of expression of TGF-alpha and TACE were found to correlate with and be predictive of a poor outcome in patients with breast cancer. This study therefore identifies a new pathway by w...
Stem cell marker identified in head and neck cancer
... 5 percent. "The CD44-positive cells contain the tumorigenic
cells, but we don't think that's a pure population of cancer stem cells. We still need to drill down further to find the subpopulation of those cells that is the pure version," Prince says....
Scientists identify pancreatic cancer stem cells
...also found these cells are at least 100 times more tumorigenic
than cancer cells that did not have one of three p... Additionally, the tumors derived from the highly tumorigenic
pancreatic cancer cells "appeared remarkably similar to the appearance of tumors taken directly from...
Oxidative stress stimulates p38 MAPK-mediated tumor suppression
...rved that increased ROS levels were also linked to tumorigenic
potential in several human cancer cell lines that were examined. The authors suggest that it may be possible for cancer cells to escape the tumor-suppressive functions of p38-alpha by desensitizing p38-alpha to oxidative stress. Indeed, many tumor...
Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment
...t cancer. Prospective identification of highly tumorigenic
colon adenocarcinoma cells enriched for stem-like ...ncers with the discovery of a population of highly tumorigenic
primary human colon tumor cells, according to researchers from Biogen Idec. "Such stem cells coul...
Cancer stem cells can go it alone
...rt to produce milk proteins. To assess the cells tumorigenic
potential, the researchers injected the cells into the breast tissue of female mice. Unable to respond to conditions that prevent normal stem cells from spinning out of control, even a single LA7 cell started to form tumors. If tumor induction was de...
Researchers identify genetic mutation that may alter tumor cell proliferation
...icated techniques to provide new insights into the tumorigenic
process, said Bert Vogelstein, MD, Director of the Ludwig Center for Cancer Genetics & Therapeutics at The Johns Hopkins Kimmel Cancer Center. James E. Thomas, PhD, of Lillys Cancer Discovery Research division, explained, AKT1 is a protein kinase o...