Tag: "tumors" at biology news
NIH awards Emory and Georgia Tech $10 million for partnerships in cancer nanotechnology
...monly used diagnostic techniques often do not find tumors
until after they are large enough to metastasize t...t time to simultaneously target and image prostate tumors
in living mice. Bioconjugated dots are chemically linked to molecules such as antibodies, peptides,...
Protein protecting brain from toxins also blocks some chemotherapy from reaching tumors
...efficacy of drugs targeting central nervous system tumors
might be improved by inhibiting this protein, a ty...is strong evidence that over-expression of Mrp4 in tumors
contributes to topotecan resistance in patients. "Our work has important implications for therapies...
New method identifies chromosome changes in malignant cells
...ts a clearer idea of what is really going wrong in tumors
and thus points to possible treatments. The researchers already used their system to identify previously unrecognized immune system genes that are deleted in breast cancer cells, suggesting possible ways in which these aberrant cells avoid being dete...
Muscling in on a deadly cancer
....) Capecchi says the cancer causes tumors
in various muscles throughout the body, primarily ... second study's key finding, mice developed muscle tumors
much like the human cancer when Capecchi and Keller did two things. First, they activated the Pax3:F...
S1P1 essential for tumor growth and is blocked by RNA interference
...jec-tion of the S1P1-specific interfering RNA into tumors
in mice, these also showed repressed S1P1 expres-s...both that S1P1 is vital for blood vessel growth in tumors
and that RNA interference technology may be of great use in anticancer therapies. TITLE: Requiremen...
Normal cells in tumors may aid cancer growth
...dy indicates that genetic damage occurs in stromal tumors
cells, and that that damage may play an important ...elopment." The findings might help explain why tumors
often behave differently, and respond differently to treatment, in people with seemingly identical c...
Combination hormone therapy doubles breast density and quadruples risk of abnormal mammograms
...ee of breast density can make it difficult to spot tumors
and other abnormalities. In addition to being harder to image, dense breast tissue also appears to be more biologically active and susceptible to malignancy. Previous research at Fred Hutchinson has shown that women under 50 with predominantly dense...
Other highlights in the October 20 JNCI
...d is used in some cancers to prevent the spread of tumors
to the tissues that cover the brain and spinal cord. The bacterial enzyme carboxypeptidase G 2 is effective for treating rare but potentially fatal accidental overdoses of methotrexate given for this purpose, according to a new study. Accidental ove...
Neurosurgeons looking at stem cells from skin to fight brain tumors
...h Thursday. Researchers found that mice with brain tumors
that were treated with stem cells showed both increased blood supply and decreased tumor growth into the surrounding brain. These mice also lived on average 50 percent longer than mice that weren't given this therapy. The annual meeting provides c...
Sandbagging cancer in the bloodstream
...ting Material: Cancer and Metastasis). While solid tumors
can be removed surgically or treated with chemothe... dramatically protects the mice against metastatic tumors
because it keeps the cancer cells "sandbagged" in the bloodstream where they are vulnerable to attac...
Potential new oncogene may be missing link in cancer-causing chain
... aggressive cells into mice, the animals developed tumors
twice as large as those caused by the original, sl...r than normal activity in five of the eight breast tumors
we tested. So, it appears that an increase of LRP6 alone may lead to breast cancer in these cases." ...
JCI table of contents November 1, 2004
...rkedly lower both in cell culture and in implanted tumors
in mice. The authors then put the SEMA3F gene into...ng tumor cells in mice. In drastic contrast to the tumors
whose cells did not contain SEMA3F, the SEMA3F-containing tumors
did not metastasize. Furthermore, t...
ORNL project earns top honor from Southeast tech transfer group
... mice and other small creatures to be screened for tumors
and genetic study while they are still alive. The technology provides three-dimensional images of the subject being studied. The device saves time and money because biologists can screen subjects individually for internal mutations in seven to 20 min...
Cell enzyme may help suppress cancer development
...TPRO gene for methylation in 43 primary human lung tumors
and their matching normal adjacent tissue. Fifty-one percent of the tumor samples were heavily methylated, while the gene in the adjacent normal tissue was essentially methylation-free. When the researchers modified laboratory-grown human lung-...
NJIT stem cell researcher to receive research award from biomedical group
...tance, could help cancer patients who've had large tumors
removed from bone, Arinzeh says. Stem cells could also help patients suffering from osteoporosis. Perhaps most importantly, Arinzeh published another paper in the Journal of Bone and Joint Surgery proving that adult stem cells taken from one patient ...
New gene target found for common brain tumors in children
...k of the brain in the cerebellum. Medulloblastoma tumors
often are characterized as looking like a large mass of stem cells. ...
New studies regarding the efficacy of antioxidants and their impact on standard cancer treatment
...t side effects without unduly protecting malignant tumors
has much to offer oncology, including: 1) a lower need for dose reduction or treatment delay; 2) an improvement in quality of life for the cancer patient; 3) less oncology staff time spent dealing with side effects and patient complaints; 4) a lower...
Signal for inflammation linked to Ras-induced tumor growth
...wth. In addition, inhibition of CXCL-8 function in tumors
expressing Ras led to a marked decrease in tumor angiogenesis. Molecules that modulate CXCL-8 expression are known targets of the Ras signaling pathway, establishing a physiological link between these signaling molecules. The researchers conclude...
UCSD discovery opens new avenues for design of anti-tumor medications
...to grow to the tumors. Without blood vessels, the tumors
were starved of oxygen and nutrients, resulting in tumors
were smaller in size than in normal mice and had dead tissue at their centers. To date, most e...
New protein identified in development of lung cancer
...lung cancers and in 14 of 15 (93 percent) of mouse tumors
than it was in the normal tissue. "This is the fi...ion that Pirh2 expression is elevated in patients' tumors
and supports the notion that it may be an important molecule in the development of lung cancer, says...
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