Scientist discover the cellular roots of graying hair
...son melanocytes proliferate uncontrollably to form tumors and are hard to kill with treatment. "Preventing the graying of hair is not our goal," emphasizes David E. Fisher, MD, PhD, director of the Dana-Farber Program in Melanoma, and senior author of the Science paper. "Our goal is to prevent or treat mela...First 'atlas' of key brain genes could speed research on cancer, neurological diseases
...ists say the map will accelerate research on brain tumors and neurological diseases that result from mutatio...of them to investigate as possible causes of brain tumors and other diseases. The Dana-Farber researchers already have homed in on specific TF genes regulatin...UCSD discovery shows how embryonic stem cells perform 'quality control' inspections
...nown to play a critical role in the suppression of tumors in both humans and mice, is also used to maintain the genetic stability of embryonic stem cells. The scientists, who included Tongxiang Lin, a UCSD postdoctoral fellow and the first author of the study, and Connie Chao, a graduate student in Xu's ...Growth of common skin cancer blocked in gene-switch mice
...ssion," said Dr. Dlugosz. In some of the regressed tumors Gli2 reactivation leads to resumption of BCC tumor growth, suggesting that the residual cell population may represent BCC tumor stem cells, but Dr. Dlugosz cautions that there is as yet no definitive evidence that tumor stem cells exist in BCC. In a...Animal experiments more stressful than previously recognized
... is also affected. In rats and mice, the growth of tumors is strongly influenced by how much the animals are handled. Dr. Balcombe's paper appears in the journal's current issue, Autumn 2004, available mid-December. Until now, humane concerns focused mainly on the experiments themselves. The new finding...Mouse brain tumors mimic those in human genetic disorder
... 2004 -- A recently developed mouse model of brain tumors common in the genetic disorder neurofibromatosis 1...cells may be essential to the initial formation of tumors and therefore may be promising drug targets; and brain images often used to determine the need for t...Brain tumor study reveals why treatment efforts fail in genetic disorder
St. Louis, Jan. 1, 2004 -- Drugs used to treat the tumors common in people with a disorder called neurofibro...lled NF1. If a cell's normal copy also is mutated, tumors can form. Children with neurofibromatosis 1 are therefore predisposed to developing a variety of ser...JCI table of contents, 3 January 2005
...all cases of papillary thyroid tumors. In sporadic tumors (where patients have not been exposed to high leve... contrast, mutations observed in radiation-induced tumors most commonly involve fusion of one end of the RET gene to the opposite end of various other genes t...Cincinnati study of Chernobyl residents uncovers new cause of thyroid cancer
...all cases of papillary thyroid tumors. In sporadic tumors (where patients have not been exposed to high leve... contrast, mutations observed in radiation-induced tumors most commonly involve fusion of one end of the RET gene to the opposite end of various other genes t...Human complexity and diversity spring from a surprisingly few (relatively speaking) genes
...sts that epileptic seizures in patients with brain tumors could be caused by an editing deficiency with regard to the channel molecule." Maas's research group recently discovered that A-to-I editing, in which adenosine is converted to inosine, is widespread among human genes and occurs frequently in a commo...Other highlights in the January 5 JNCI
... VEGFR-3 was known to inhibit lymphangiogenesis in tumors and to reduce metastasis to lymph nodes. These ob... cancer, nonsmall-cell lung cancer, or other solid tumors who were assigned to the placebo group in two trials of zoledronic acid. High levels of each marker ...Study examines relationship of vitamin A pathway to breast tumor progression
...ession. The authors also observed that the breast tumors derived from these cells that expressed normal CRBP-I regressed, whereas those that did not express CRBP-I continued to grow. "Our in vivo data suggest that somatic CRBP-I loss of function results in a local deficit in vitamin A storage and meta...FDA approves ABRAXANE(TM) for metastatic breast cancer
...the increased uptake of albumin by rapidly growing tumors results in increased delivery of chemotherapeutic drugs to the tumor. The clinical relevance of these findings is unknown at this time. About Breast Cancer According to the American Cancer Society (ACS), while early detection efforts have decrease...University of Pittsburgh receives award to study new theory of breast cancer development
...nnenberg and colleagues will examine breast cancer tumors and surrounding tissue for cells expressing both markers associated with normal stem cells and breast cancer cells. They expect to find that early tumor stem cells will express drug-resistant pumps that can survive treatment while the majority of can...Research identifies promising route for treating age-related hearing loss
...to keep dividing and dividing, which might produce tumors in the inner ear. So, Zheng-Yi and his colleagues will be seeking ways to inactivate the gene only long enough to allow a clinically useful amount of proliferation, before turning the gene back on." The approach, he said, will require a greater under...Found: Missing sequence of the human Y chromosome
...oma locus, which is responsible for development of tumors associated with the undifferentiated gonad, has been genetically mapped to the region. Because the "missing" sequence described in this study contained eight putatively active genes, further functional testing of these genes may reveal insights into...Mitochondrial DNA mutations play significant role in prostate cancer
...tate cancer cells with the mutant mtDNAs generated tumors that were on average seven times larger than the p...ulate cell growth, the researchers then tested the tumors for oxygen radical production. The tumors with the mutant mtDNAs generated significantly more oxyge...New cancer gene identified by Memorial Sloan-Kettering scientists
... B-cell and T-cell lymphomas. They also found that tumors with high levels of Pokemon protein were much more...t is likely that the protein plays a role in solid tumors as well, and we now have means to specifically interfere with the activity of these transcription fa...Journal of Nuclear Medicine Supplement summarizes current molecular radiotherapy
...owing role in the care of thyroid cancer and other tumors in the future," Larson said. Larson and Krenning also draw attention to the importance of cancer survivor groups in setting policy and promoting cancer awareness. This essential resource includes the introduction, "A Pragmatic Perspective on Molecu......n mutated in non-small-cell lung cancers, and that tumors that harbor such mutations are sensitive to two dr...e. The researchers found that those patients whose tumors had KRAS mutations had not shown an anti-tumor response when they were treated with either erlotinib...