Researchers add new tool to tumor-treatment arsenal
...monstrates the potential effectiveness of treating tumors by combining agents that damage DNA with a drug th...s Dr. Thomas. "Since about 50 percent of all solid tumors contain p53, such a drug combination could dramatically improve the treatment of solid tumors."...Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
...t on cancer: 88 percent of "normal" male rats have tumors at death. The male rats that had a lifelong deficiency of growth hormone had substantially fewer tumors 63 percent and the percent of tumors that were fatal was reduced from 57 percent to 31 percent. T...New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
...e National Academy of Sciences. Most primary brain tumors have a high mortality rate, with people surviving ...r Center. In the study, 20 participants with brain tumors underwent diffusion MRI before beginning a new treatment involving chemotherapy, radiation therapy o...BRCA1 causes ovarian cancer through indirect, biochemical route
...ells did indeed give rise to ovarian tumors, those tumors did not arise in granulosa cells. Instead, when th...ted BRCA1 genes in their granulosa cells developed tumors there as well. "This not only underscores the relevance of our mouse model to human cancer," Dubeau ......ld prove efficacious in controlling the ability of tumors to recruit new blood vessels, grow and spread to distant sites."...Natural tumor suppressor in body discovered by UCSD medical researchers
...n certain cancer cells to prevent the formation of tumors has been discovered by researchers at the University of California, San Diego (UCSD) School of Medicine. Located on chromosome 18 and called PH domain Leucine-rich repeat Protein Phosphatase (PHLPP, pronounced "flip"), the tumor suppressor is descr...Balancing act at chromosome ends
...rmation. The Hsp90 protein is increased in several tumors and may increase the addition of telomere repeats several-fold. Chung's group has now identified a second protein, called MKRN1 that acts on hTERT to promote its degradation. MKRN1 belongs to a class of proteins called ubiquitin ligases that catalyze...Gene mutation protecting against malaria linked to prostate cancer incidence in African-American men
...ing the formation of new blood vessels produced by tumors in order to gain nutrients needed to grow. Dr. Ale...e class of angiogenic factors released by prostate tumors are chemokines, small proteins that promote angiogenesis by binding to receptors on the cells lining...Chronic inflammation caused by too little stomach acid leads to gastric cancer
...t of the stomach, compared to the antrum where the tumors were developing," Merchant says. "The antrums we studied had a 50-percent to 75-percent decrease in the cell death rate. Rates of cell growth and reproduction were about the same in both stomach compartments. "So we think that gastric cancer, at leas...Pair of cancer genes found to drive both cell migration and division
...divisions. In addition, cell migration can lead to tumors spreading and developing in different places in the body," says Peter Devreotes, Ph.D., professor and director of Cell Biology at the Johns Hopkins School of Medicine's Institute for Basic Biomedical Sciences. "Now that we know that PTEN and PI3K are...Researchers test new therapy for advanced melanoma
... If electroporation can deliver the gene to these tumors reliably and without serious side effects, melanom...gnaled the immune system to recognize the melanoma tumors as abnormal and attack. Eighty percent of the mice were cured with this therapy -- their tumors dis...PNAS highlights for the week of April 4 - 8
...in two phases: radial and vertical. Vertical-phase tumors are more likely to metastasize (spread cancer to o...eased risk of metastasis. However, some metastatic tumors retained a gene expression pattern characteristic of the radial growth phase, which implies that bot...Other highlights in the April 6 JNCI
...mals, including mammals. It has been reported that tumors grow faster in animals with a disrupted circadian ...adian clock and cell cycle genes in the livers and tumors of mice synchronized by normal light and dark schedules (normal circadian clock) or with schedules d...SV40 not implicated in mesothelioma
...colleagues argue that the low levels identified in tumors in earlier studies are insufficient to consider SV... present in one out of 5,000 cells. None of the 69 tumors they tested contained detectable levels of SV40....$3 million donation accelerates TGen breast cancer research
...reast cancer. 2. A study that will determine which tumors are most likely to respond to a particular therapy...rmine the most effective treatments for individual tumors based on their genetic information. Using cutting-edge technology, this research will likely identif...Viruses may one day help treat brain tumors
...lated that condition. They injected the virus into tumors 19 days after implantation and when the mice began showing symptoms, which is similar to the case in human treatment. In this experiment, two of 10 animals treated with the ICP34.5 virus survived 24 days after implantation. Of mice treated with the ...International gathering of scientists looks toward future of cancer research
...-threatening to new therapies capable of targeting tumors while limiting damage to healthy cells and tissue. The opening plenary session, "The Impact of Scientific Discovery on Cancer Diagnosis and Treatment," will feature a talk by Clifton Leaf, executive editor of Fortune magazine, whose cover article las...Research news from the Friedman School of Nutrition Science and Policy at Tufts University
...y found that those men with less advanced prostate tumors had higher concentrations of overall polyunsatura...study also found that those men with more advanced tumors had a lower ratio of omega-3 fatty acids to omega-6 fatty acids. The study was led by Vincent Freem...Unchecked DNA replication drives earliest steps toward cancer
...ic oncogenes or tumor suppressor genes. Full-blown tumors and metastatic cancers, however, often exhibit many genetic mutations, sometimes dozens in a given tumor. An important scientific question, and one with significant clinical implications, has been what happens after the initial mutation that leads to...Penn researchers determine structure of binding site of colon-cancer drug and its protein target
... "the protein EGFR needs to not only be present on tumors but it needs to be there and be active," says Ferguson. "Understanding the structure could help us design alternatives to Erbitux that would be easier to deliver in small-molecule medications to be taken as a pill," as opposed to the current intrave...