Notorious cancer gene may work by destroying messenger
... Researchers discovered that PMR1 is activated or turned on by another molecule, an energy-packing protein called Src (pronounced sark). Discovered in 1977, Src became the first oncogene mutated genes that help make cells cancerous. Oncogenes are altered forms of genes that control cell growth and cel...Gene hunters, patent prospectors leave indigenous communities in Pacific feeling besieged, betrayed
...een conducted and one biomedical experiment nearly turned the tiny Cook Islands into a "rogue state" in the eyes of the US government, according to the book. "Researchers are harvesting and patenting the Pacific region's genetic resources by simply gathering and taking ownership over almost everything in ...Biotechnology Study Center honors Joan V. Ruderman, Salvador Moncada and Charles N. Serhan
...s, protectins, etc. The receptors for these agents turned out to recognize both endogenous ligands and novel derivatives that hold great pharmaceutical promise. Most recently he has found that some of these lipid intermediates function in the nervous system as regulators of neurogenesis. His laboratory lead...Keeping the body in sync -- the stability of cellular clocks
...r Lab at the University of Geneva, the researchers turned to dynamical systems theory and developed a mathematical model that identified the molecular parameters responsible for the stability of the cellular clocks. Stability is a measure of how fast the system reverts to its initial state after being pertu...New agreement helps protect thousands of rice varieties -- the planet's most important food source
...ast Timor, India, Nepal, and the Philippines, have turned to the IRRI genebank to restore native varieties of rice that, for a variety of reasons, had disappeared from domestic production. Last year, IRRI introduced a new variety of rice able to withstand being completely submerged in a flood. And, this ...Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease
... to the use of humanstem cells - either stem cells turned into neural progenitors from humanembryonic stem cells - or isolated directly from the nervous system(called "adult" stem cells to distinguish them from embryonic stem cellseven though they are taken from developing brain tissue). Both types ofhuman ...Genes and groups of genes commonly shared between species, studies show
...ne near Redding, Calif. This microbial biofilm has turned out to be an ideal research subject, Banfield said, because the simple community contains few enough organisms that they can be used as a model system to uncover aspects of how microbes interact with each other and their surroundings in ways that are...Solar energy conversion offers a solution to help mitigate global warming
...venly beneath Earth's surface. When fossil fuel is turned into useful energy through combustion, it often produces environmental pollutants that are harmful to human health and greenhouse gases that threaten the global climate. In contrast, solar resources are widely available and have a benign effect on th...Breast cancer treatment heats up
... off as soon as the alternating magnetic field was turned off and then passed out of the body. This process is described in detail in the JNM article, "Thermal Dosimetry Predictive for Efficacy of 111In-ChL6 Nanoparticle AMFInduced Thermoablative Therapy for Human Breast Cancer in Mice." "Using heat to k...Ovarian cancer may mimic fallopian tube formation
... ultimately form ovarian cancer. When this gene is turned on in an embryo, it leads to the development of fa...t steps are to find out why paired box gene 8 gets turned on and to discover its targets in order to find out of it turns on another decision-making gene or a...Penn researchers discover new molecular path to fight autoimmune diseases
...ound that when the histone acetyl transferases are turned on, or when the histone deacetylases are turned off, the immune regulatory cells work better and longer. As a consequence of the action of the acety...Light-activated compound silences nerves, may one day help epileptics
...ed result, reported online in Nature Neuroscience, turned several lights on in researchers' heads. "This is daydreaming at this point, but we might one day combine this drug with a small implanted light to stop seizures," says senior author Steven Mennerick, Ph.D. associate professor of psychiatry and of a......M) was developed at EMBL in the early 2000s it has turned into one of the most powerful tools in cell biology. SPIM allows scientists to study large, living specimen along many different angles, under real conditions and with minimal harm to the specimen. Snapshots of the specimen obtained in different plan...Genome sequencing reveals key to viable ethanol production
...ed how genes responsible for biomass breakdown are turned on in a microorganism that produces valuable ethanol from materials like grass and cornstalks. Waste products such as grass clippings and wood chipsonce thought too difficult to turn into ethanolmay soon be fodder for hungry, gene-tweaked bacteria.Th...Weizmann Institute scientists discover genes that can slow cell division and may fight cancer
...e in a number of separate waves in which genes are turned on and off for different periods of time. In the first wave, the activity of a few genes rises for about 20 to 40 minutes. These are the genes that cause the cell to divide. In contrast, the next four waves, ranging from 40 to 240 minutes after the s...Looking for life on Jupiter's icy moon Europa
...ock outcroppings, where fossils will be found. Ice turned on its edge is just a geologic outcrop to me let's go there and see if we can find evidence of past or present life." Surface sites that might contain habitats with life or fossils include the areas of refrozen ocean, chaotic terrains with tilted...Killing the messenger RNA -- But which one?
... ramifications of microRNA editing in depth. As it turned out, the gene they selected, known as PRPS1, codes for an essential enzyme involved in synthesizing uric acid. If levels of the enzyme are poorly regulated, a number of health problems can arise. For example, too-high levels of the enzyme can cause u...Primitive yeast yields secrets of human cholesterol and drug metabolism
...g that whatever controls the P450s likely would be turned on and off at roughly the same time as the P450 enzymes themselves, the researchers found that Dap1 does just that in the yeast cell. To figure out what Dap1 does, Espenshade and colleagues genetically altered yeast cells to lack Dap1. Those cells...Fetal heart-cell enzyme important in onset of heart failure
...nd therefore how large groups of related genes are turned on and off. During development HDAC normally regulates proliferation of heart cells in the embryo. "This makes sense if a molecular pathway in which HDAC has a major role is re-expressed--the adult heart instead makes the cells it already has bigger ......ite bacterial mass, indicating that the system had turned from low to no oxygen. "The fact that we saw no fish - alive or dead - suggests that many were able to escape," says Lubchenco. "In previous years, fish that have escaped the low-oxygen area appear to have returned once the oxygen was renewed. Thi...