New method identifies chromosome changes in malignant cells
...able some genes and overuse others, allowing their unchecked growth into tumors. The most aggressive of these distortions occurs when cells delete or multiply chunks of their own chromosomes. Cells can simply snip strings of genes from the chromosome, or make many extra copies of the string and reinsert it int...Delays in cutting greenhouse gasses could harm environment
...eaching them: a slow, controlled increase; a fast, unchecked increase followed by a rapid leveling; or a fast, unchecked increase that overshoots the target followed by a reduction down to the target. The researchers foun...Inherited gene may increase risk for prostate cancer by 50%
...n KLF6 fails to function properly cell growth goes unchecked and cancer may results. It has since been discovered that KLF6 defects are implicated in a number of other human cancers, including colorectal, lung and liver. The variant of the gene investigated in the report published this week produces a an alte...New advances may slow tumor growth in pancreatic cancer
... growth of cells, and these cells continue to grow unchecked until they eventually become tumors. "Previously, we found that Smad7 blocks the ability of TGF-beta to inhibit the growth of these cancer cells," said study co-author Dr. Nichole Boyer Arnold, a postdoctoral fellow at DMS and a member of the Norris ...MBL researchers probe how an ancient microbe thrives and evolves without sex
...l reproduction compensates for, but which often go unchecked and are believed to contribute to mutation (and eventually extinction) in species that reproduce asexually. To learn more about the bdelloid rotifers' unique ability to evolve without sex, Arkhipova and Meselson studied portions of different bdel...Improving the potential of cancer vaccines
... diseases will result because the immune system is unchecked and goes on to attack the body's own tissues. His group previously reported the existence of tumor-specific Treg cells at tumor sites. "Thus, the tumor cells use these Treg cells to protect themselves," said Wang. "In fact, tumor cells can actively r...Report focuses on challenges to unlocking future promise of vaccines
... been profound. Many diseases that formerly raged unchecked are now under control and others have been eliminated in parts of the world. Despite this success, infectious diseases continue to be public health problems particularly in developing countries where vaccines are unavailable, unaffordable, or both,"...Groovy protein essential for promoting cancer development
...enzyme whose excessive activity contributes to the unchecked growth of as many as 90 percent of human tumors. The enzyme is vital for some rapidly dividing cells such as those in a developing embryo where it extends telomeres, the regions of highly repetitive DNA found at the ends of chromosomes. In most he...Shopping list gets longer not less choosy in some of world's largest fisheries
...se of the higher-value stocks if fisheries develop unchecked and without considering these interactions. "Navigating these conflicts is moving to the forefront of contemporary marine fisheries management and conservation." Fishing down the food web emerged as a concern in the late 1990s when Daniel Pauly of t...World faces challenge as life expectancies lengthen, scientist says
... If anti-aging technologies are distributed in the unchecked free market, "it's entirely likely to me that we'll wind up with permanent global underclasses, countries that will get locked into today's mortality conditions," Tuljapurkar said. As the gap widens and rich countries continue to invest in anti-aging...Liver cancer linked to cellular repair pathway
DURHAM, N.C. The unchecked activity of a cell signaling pathway crucial in embryonic development and the liver's response to injury leads to liver cancer, researchers from Duke University Medical Center and John Hopkins University School of Medicine have found. Because the pat...New model of p53 regulation proposed that suggests novel anticancer strategy
...nd balances ensuring that p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells. Up to this point, researchers thought Mdm2 and Mdm4 collaborated to halt the activities of p53. As a powerful tumor suppressor, p53 turns on genes that either halt cell division, to allow time fo...JCI table of contents, May 18, 2006
...ered, making T cells unresponsive and allowing for unchecked viral persistence. Brooks et al. show that deletion of immunodominant T cells and functional inactivation can be prevented in vivo in mice during persistent LCMV infection, resulting in a more diverse virus-specific T cell repertoire and the long-ter...U. of Colorado team solves mystery of carcinogenic mothballs
...tain cell groups that acts as a "brake" to prevent unchecked cellular proliferation similar to the process that triggers the formation of cancerous tumors, said Xue. While naphthalene and PDCB have been shown to cause cancer in rodents and are classified by the National Toxicology Program and the Internationa...Speeding discovery of the 'human cancer genome'
...lly contribute to the cancerous cells' ability for unchecked proliferation or spread. Simply sorting through those differences one by one takes time and money, said Lynda Chin of the Dana-Farber Cancer Institute and Harvard Medical School. "There has to be a way to prioritize the effort," she said. Chin...Researchers image molecular motor structural changes
...ing how motors work in cancer cells, which undergo unchecked cellular division, might lead to new anticancer therapies. The team, from Duke University Medical Center, the National Institute of Advanced Industrial Science and Technology in Japan, and the Medical Research Council's Laboratory of Molecular Biolo...Genetic disorder linked to rapid lung function decline in some World Trade Center rescue workers
...ally-occurring healing process, thereby leading to unchecked inflammation in these areas. Individuals with low levels of A1AT are at an increased risk for chronic lung and liver disorders. "A1AT deficiency is a genetic defect with variable penetrance," said the study's lead researcher Gisela Banauch, MD, Mont...Brown cancer biologists identify major player in cell growth
...cer. Since a key characteristic of cancer cells is unchecked growth, the research identifies potential targets for new treatments. "As a scientist and a physician, I am tremendously excited," said Alan Rosmarin, M.D., an associate professor in the Department of Medicine and the Department of Molecular Biolog...Problem forgetting may be a natural mechanism gone awry
...se, if that balance is disrupted to favor LTD, the unchecked synaptic weakening leads to memory loss. The good news is we are developing a good understanding of these mechanisms, and that will help us find ways to protect memory. Fosters work was supported by the National Institutes of Health and an Evelyn F...Book explores history, causes of allergy and asthma epidemic
...s raging asthma and allergies afflictions continue unchecked from their first stirrings in the 1800s to the pre...idemic that began after World War II and continues unchecked into the present. "Asthma disproportionately affects people of color living in impoverished inner-...