Research shows skeleton to be endocrine organ
... understanding of the function of the skeleton and uncovers a crucial aspect of energy metabolism, said Gerard Karsenty, M.D., Ph.D., chair of the department of Genetics and Development at Columbia University Medical Center, Paul Marks Professor in the Basic Sciences, and senior author of the paper. These res...Short chromosomes put cancer cells in forced rest
...study, appearing online this month at Cancer Cell, uncovers an alternate response where cells simply - and permanently - stop growing, a process known as senescence. In an unusual set of experiments, the research team first mated mice with nonoperating telomerase to mice carrying a mutation that predisposed...NYU scientists identify how development of different species uses same genes with distinct features
...oyed by two independently evolved species not only uncovers those features essential to this portion of development, but also shows that we are now in a position to understand another speciesin this case, the waspother than flies in the same depth," explained Desplan....Changes in dietary protein may override inherited skeletal abnormalities
... led by Gerard Karsenty of Columbia University now uncovers new details of the molecular machinery that governs bone formation. Specifically, the researchers found that loss of a gene that is mutated in patients with a condition called neurofibromatosis (NF) type I causes an abnormal increase in activity of g...Nerve fibers need specific growth factor chemical to form connections within the brain
...ts, according to UC Irvine scientists. The study uncovers how cholinergic neuronal circuits, which help the cerebral cortex process information more efficiently, rely on neurotrophin-3, a chemical that stimulates nerve growth. The scientists have determined the circuits need this chemical in order to recogn...Tiny shock absorbers help bacteria stick around inside the body
...ost animal or person. "Research on these fimbriae uncovers something that's essentially a mechanical nanotechnological device created by nature, and gives us the opportunity to adapt such a system for biotechnological and even other technical uses," said study co-author Dr. Evgeni Sokurenko, associate profes...Scientists uncover critical step in DNA mutation
...nderlies many forms of cancer. The research, which uncovers knowledge that could be critical to the development of strategies for cancer prevention and treatment, appears in the August 2006 edition (Volume 128, issue 33) of the Journal of the American Chemical Society. The process that gives rise to mutatio...Expression of 'Blimp1' gene leads to the discovery of cells responsible for skin's sebaceous gland
... cells responsible for oil production develop, and uncovers clues about how stem cells renew and differentiate. The research focuses on the skins sebaceous gland, which is linked to the hair shaft and secretes an oily mixture called sebum. But until today how the sebaceous gland is formed during development w...Tissue rigidity promotes tumor progression
...al force can regulate cellular behavior. The study uncovers a link between tissue tension and tumor formation, suggesting that the stiffness of a tissue can influence molecular signals that promote the malignant behavior of tumor cells. The findings, published in the September issue of Cancer Cell, provide ex...Insight into cell metabolism will help interpret PETs, MRIs
...netic resonance imaging (MRI) test. The discovery uncovers a key piece of information that's been missing for years about cell metabolism -- how the compound beta-nicotinamide adenine dinucleotide (NADH) interacts in the mitochondria. The researchers discovered that some molecules of NADH are bound to other ...DNA from feathers tells tale of eagle fidelity
...latively rare instance in which DNA fingerprinting uncovers genetic monogamy in a bird population," DeWoody said. Unlike their smaller songbird cousins, most raptors are believed to be truly monogamous, and this study provides the first genetic confirmation of monogamy in at least one species, DeWoody said. "...Gene variations explain drug dose required to control seizures
...hs to get their seizures under control. This study uncovers factors that might determine, in advance, which patients will need the higher dose." Before any such pharmacogenetic approaches can be put into practice, they must be explicitly evaluated for clinical utility in improving patient outcomes, Goldstein ...UT Southwestern researchers uncover gene variant that appears to predict type 2 diabetes
...at risk for type 2 diabetes. "This important study uncovers one of the genes that appears to predispose to type 2 diabetes," said Dr. Scott Grundy, director of UT Southwestern's Center for Human Nutrition and the study's senior author. In the study available online and scheduled to appear in the April issue o...JCI table of contents, 3 January 2005
Cincinnati study of Chernobyl residents uncovers new cause of thyroid cancer Cincinnati University scientists studying papillary thyroid cancer in Chernobyl residents following the 1986 nuclear plant accident have identified a novel genetic mutation event that occurs as a result of their exposure...Study in Royal Society journal on possible genetic factors in social responsiblity
... NR4 7TJ Inbreeding uncovers fundamental differences in the genetic load affecting male and female fertility in a butterfly by Dr IJ Saccheri, Dr HD Lloyd, Dr SJ Heylar and Professor PM Brakefield The focus of inbreeding depression studies has been on vi...