Findings show how toxic proteins rob Alzheimer's patients of memory
...yloid beta proteins clumped together, are tiny and undetectable in conventional neuropathology; fibrils are much, much larger. While fibrils are immobile toxic waste dumps, ADDLs are soluble and diffuse between brain cells until they find vulnerable synapses. (Single pieces of amyloid beta protein in the brain is...Researchers discover new gene in colon cancer
...15-PGDH, is found in normal cells and is virtually undetectable in colon cancer cells. When the researchers restored the gene in tumor cells and injected them into immune-deficient mice, the mice showed little or no tumor development. The study appears in the Dec. 14 issue of the Proceedings of the National Aca...JCI table of contents, 3 January 2005
...ividuals. Many of these people maintain clinically undetectable loads of the HIV virus, however a pool of persistently HIV-infected cells remains and prevents the complete eradication of HIV infection. New treatment strategies are now focused on increasing the turnover of latent pools of virus through activation ......ividuals. Many of these people maintain clinically undetectable loads of the HIV virus, however a pool of persistently HIV-infected cells remains and prevents the complete eradication of HIV infection. New treatment strategies are now focused on increasing the turnover of latent pools of virus through activation ...Sinking coastlines may precede large subduction zone quakes
... Before that, you've got subsidence that is almost undetectable to the people living there. But you could detect it with a tiltmeter. We have shown that we can detect it in the paleoenvironment." The study was conducted by Scott and Lipps, both micropaleontologists, along with Dalhousie undergraduate Andrea D. Ha...Scientists propose new method for studying ion channel kinetics
...channel gating kinetics that are used to represent undetectable changes between different open and closed states. ...ocesses, the researchers are able to represent the undetectable changes between different open states, and between different closed states. However, there are an en...A decade after launch, ERS-2's mission continues
...evation models (DEMs) and also revealing otherwise undetectable changes occurring between image acquisitions. In effect InSAR works like a sophisticated version of 'spot the difference', identifying millimetre-scale ground movement to reveal urban subsidence, landslides or seismic motion even the rhythmic 'brea...New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
...ed a new imaging technique to reveal the otherwise undetectable inflammation of pancreatic islets in recently diagnosed diabetic mice. As T lymphocytes invade the pancreas, blood vessels swell, become more permeable, and leak fluid as well as small molecules carried in the fluid into surrounding tissues. In pre...Image of myosin-actin interaction revealed in cover story of Molecular Cell
... to familial hypertrophic cardiomyopathy (FHC), an undetectable condition resulting in death by sudden cardiac arrest in otherwise healthy young adults. Contributors to this work include: Niels Volkmann, Ph.D., assistant professor and first author on this publication, Dorit Hanein, Ph.D., associate professor, Hon...$16 million grant advances nanomedicine at Washington University
... deep into the body to locate and highlight tumors undetectable by typical methods. While at the tumor site, the nanoparticles can deliver therapeutic agents to destroy the tumor. To advance this promising technology, the National Cancer Institute (NCI) has awarded $16 million over five years to the School of Med...Study sheds light on signaling mechanism in stem cells, cancer
...n the cells exposed to cyclopamine, Smoothened was undetectable on the cilium. Scientists have known that cyclopamine inhibits Hedgehog signaling and can prevent Hedgehog-dependent cancers from spreading. The demonstration that the drug affected Smoothened movement to the cilium suggests how cyclopamine inhibits...JCI table of contents November, 2005
...p to 9.1 years of effective antiviral therapy with undetectable levels of HIV in their plasma. Their data also suggest that latently infected, resting CD4+ T cells may become reactivated, most likely as a result of normal immunologic responses to various antigens and cytokines. In turn, virions released during t...The reason why antiviral therapy can't annihilate HIV infection, and what to do about it
...p to 9.1 years of effective antiviral therapy with undetectable levels of HIV in their plasma. Their data also suggest that latently infected, resting CD4+ T cells may become reactivated, most likely as a result of normal immunologic responses to various antigens and cytokines. In turn, virions released during t...Pall filtration technology verified to remove arsenic from drinking water
...l AriaTM Microfiltration System reduces arsenic to undetectable levels (below 2 ppb), exceeding the EPA standard f...as found at 160 ppb, the system removed arsenic to undetectable levels, less than 2 ppb. Based on these results, the Fallon Paiute-Shoshone Tribe is using the Pall...Mercury in atmosphere could be washed out more easily than earlier believed
... a million," he said. "It can go from being nearly undetectable in the air to being toxic to larger organisms." Swartzendruber presents his team's findings Thursday during the American Geophysical Union's fall meeting in San Francisco. He is part of a team that began taking measurements of atmospheric mercury le...Chemical warfare agent detection technology used to treat lung disease
...hat one day we will be able to detect a previously undetectable tumour metabolising inside a human lung simply by asking a patient to breathe into a device like this. For now our aim to use the microDMx sensor to develop better instruments which will improve patient care and treatment. "The potential is such that...Protein found to control tumor growth in certain breast cancers
...minished rapidly in these mice, becoming virtually undetectable by the end of the experiment. In MCF-7 cells where Nod1 was absent, the tumors flourished. In addition, there was an increased sensitivity to estrogen-induced cell proliferation and a failure to undergo Nod1-dependent apoptosis in vitro. Taking ...Search for alien life challenges current concepts, says U. of Colorado prof.
...ture and biochemistry than known life and would be undetectable with current techniques like microscopy, cell cultivation and Polymerase Chain Reaction amplification, the authors wrote. Despite new suites of sophisticated instruments developed in recent years, the ability of scientists to detect life on Mars or ...Carcinogens from parents' tobacco smoke found in their babies' urine
...e present. In children of smokers whose babies had undetectable levels of NNAL in their urine, the average number of cigarettes smoked by family members was reported at 27 per week. "With more sensitive analytical equipment, the NNAL from urine of babies in lower frequency cigarette smoking households would most...CHAVI announces international search for genes affecting HIV response
...ome people naturally hold the virus down to almost undetectable levels while others lose control of it quickly." The newly organized group, called EuroCHAVI, will recruit 600 patients from nine cohorts. "This will be is the largest cohort assembled for large-scale analysis of genetic differences among HIV-infecte...