JCI table of contents: March 1, 2006
...gotta go: genetically modified mice reveal how the urinary tract develops The ureters are tube-like structures of the urinary tract that direct urine from the kidneys to the bladder. Researcher Andreas Kispert and colleagues f...Researchers discover botulism toxin's insidious route into nerve cells
...ed to treat forehead wrinkles, migraine headaches, urinary retention, eye muscle disorders, and excessive sweating. The same toxin also has more nefarious uses, and is considered a potential bioterror threat because it can kill people by paralyzing motor nerves in diaphragm muscles, causing breathing to stop...Scientists develop new concept with potential to help predict how individuals may respond to drugs
...a body's drug response. After creating a 'pre-dose urinary profile' for each rat, the researchers used computer modelling to relate the nature of the pre-dose metabolite profile to the nature of the post-dose response. Professor Jeremy Nicholson, from Imperial College London, who led the research, says: "Thi...Scientists solve 30-year-old mystery of mutant mouse's kidney woes
...he protein doesn't get properly distributed in the urinary system," says senior author Feng Chen, Ph.D., assi...n to the bladder and other downstream parts of the urinary system." When scientists used an antibody to identify where aqp2 is in the kidneys of the mutant mi...Patent awarded for LSUHSC-developed peptide that blocks lethal toxins of anthrax
...as aeruginosa is an opportunistic pathogen causing urinary tract infections, respiratory system infections, dermatitis, soft tissue infections, bacteremia and a variety of systemic infections, especially in those with immunosuppression related to cancer, HIV and severe burns. P. aeruginosa is known for its ...Injecting stem cells from a woman's own muscle may effectively treat urinary incontinence
...dy of its kind in North America, women with stress urinary incontinence (SUI) were treated using muscle-deriv...re safe to use and appear to improve female stress urinary incontinence." Previous studies at the University of Pittsburgh School of Medicine in animal models ...Proteus mirabilis will give up its genetic secrets at ASM meeting
... can cause kidney stones, as well as hard-to-treat urinary tract infections. Data from the first complete gen...d protect people from infection." "E. coli causes urinary tract infections in otherwise healthy individuals, but P. mirabilis causes more infections in those ...Innovations needed to monitor kidney health
...ology of diabetic nephropathy and newly identified urinary markers of diabetic kidney damage to develop a pre... approach directly aiming at developing a clinical urinary test will be supported by extensive basic research on the mechanisms and biomarkers of diabetic neph...Attack is the best defence against urinary tract infection
...in explaining how the body protects itself against urinary tract infections; with the help of an endogenous a...ody defends itself against bacterial attack in the urinary tract. "Antibiotic-resistant bacteria are a growing problem," explains research leader Professor An...New research clarifies roles of calcium, vitamin D, and protein in bone health, fracture risk
...ts bone loss during aging. "And we believe that if urinary levels of estrogen metabolites are high then estrogen levels in the body are also high," Armamento-Villareal said. According to Armamento-Villareal, dietary calcium appears to be optimally absorbed by the body. But Armamento-Villareal cautioned the ...UCLA researchers transform stem cells found in human fat into smooth muscle cells
... smooth muscle cells for tissue engineering in the urinary tract, including the urethra. ...PSA test has higher accuracy for patients taking finasteride
...rug decreases prostate swelling and helps men with urinary problems. However, an increased number of high-grade tumors in men taking finasteride in the Prostate Cancer Prevention Trial (PCPT) has some physicians worried about the effect of the drug. Ian M. Thompson, M.D., of the University of Texas Heal...Tiny shock absorbers help bacteria stick around inside the body
...ound and form an infection, like those seen in the urinary tract, for instance. The catch bonds release their... persist in turbulent environments, like the human urinary tract or intestines."...Compounds in cranberry juice show promise as alternatives to antibiotics
...cused on the ability of cranberry juice to prevent urinary tract infections (UTIs), which each year affect ei...revent bacteria from adhering to the lining of the urinary tract. The new findings reveal how the compounds interfere with adhesion at the molecular level. Th...Acorda announces positive Phase 3 Fampridine-SR study in people with multiple sclerosis
...acebo group: falls (15.8 percent vs.15.3 percent), urinary tract infection (13.6 percent vs.13.9 percent), di...d during an occurrence of sepsis associated with a urinary tract infection. No deaths occurred during the study. One death was reported for a subject five wee...Urgent and sustain action needed to prevent obstetric fistula
...ng the vagina and bladder, resulting in continuous urinary incontinence in women. The injury is a common complication of obstructed labour in developing countries, despite having been virtually eradicated in developed countries thanks to universal access to basic obstetric care. The paper suggests that the ...Tips from the journals of the American Society for Microbiology
...in humans such as neonatal meningitis, septicemia, urinary tract infections and pneumonia. Avian E. coli pathogens (APEC) are also believed to cause urinary tract infections in cats and dogs, septicemia in calves and pigs, and systemic colibacillosis in bir...New findings may lead to treatment for anxiety in Rett Syndrome
...ECP2, display elevated stress hormones measured by urinary cortisol levels. New studies may shed light on whether much of the anxiety of these children is a response to the subjective experience of RTT, or is an intrinsic aspect of the disorder. The lab of Huda Zoghbi at Baylor College of Medicine has been...Exposure to dioxins influences male reproductive system, study of Vietnam veterans concludes
... complications such as an inability to urinate and urinary tract infection. Surgery is sometimes needed. Dr. Claus Roehrborn, professor and chairman of urology at UT Southwestern and a study author, said, "We know that dioxin causes many endocrine disturbances in the human body. The study indirectly proves......st a large group of bacteria that cause pneumonia, urinary tract infections, gastritis, stomach ulcers, food poisoning and other disorders. Moenomycin also kills bacteria in an unusual way; it binds directly to enzymes that bacteria need to form a cell wall. Although used as a growth promoter in animals, mo...