Identified mechanism in the malaria parasite to help it adapt to infected individuals
...e biology of this parasite will allow us to design vaccines with a high likelihood of success....Handicapping tuberculosis may be the way to a better vaccine
...ould the pathogen appear again. The most effective vaccines induce the immune system to produce memory T lymphocytes, which are crucial to establishing life-long immunity. Of course, pathogens have tricks to evade the immune system. M. tuberculosis lives in the lungs, in immune cells called macrophages. A ...Developing a more effective vaccine for tuberculosis
...rch effort designed to develop new, more efficient vaccines that protect all individuals from tuberculosis. ...mportance of this study for the development of new vaccines to control the tuberculosis pandemic is discussed in more detail in the accompanying commentary by W...JCI table of contents: August 1, 2007
...rch effort designed to develop new, more efficient vaccines that protect all individuals from tuberculosis. ...mportance of this study for the development of new vaccines to control the tuberculosis pandemic is discussed in more detail in the accompanying commentary by W...New target for HIV/AIDS drugs and vaccine discovered
... drugs to fight the HIV/AIDS virus, as well as new vaccines to prevent infection. It has been known that HIV proteins disable the antibody-forming part of the immune system (the homeland defense or acquired immune system). In this report, researchers demonstrate for the first time how the HIV-1 Nef viral prot...First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
...ey might be able to rationally design therapies or vaccines to mimic these naturally occurring genetic advantages, he notes. In 2006, CHAVI researchers launched an effort to pool genetic data from HIV-positive individuals who had enrolled in nine studies based throughout Europe and in Australia. Together, ...Universal flu vaccine being tested on humans
...50 million. Why an annual vaccine? Todays flu vaccines need to be adapted every year and, consequently, t... provides broad and lifelong protection - like the vaccines we have for polio, hepatitis B or measles - is not yet available. Universal flu vaccine In the ...Vaccine trials inject hope into koala's future
...our studies on the development of human chlamydial vaccines done in the mouse model. We have identified several novel vaccine proteins that we hope will protect koalas as well." Professor Timms said chlamydia in koalas was a significant cause of infertility, urinary tract infections, and inflammation in th...Immune system 'escape hatch' gives cancer cells traction
...the teams findings suggest why experimental cancer vaccines have to date been plagued by T-cell tolerance, a weakened rather than strengthened immune response, says Jonathan Schneck, M.D., Ph.D., one of the studys authors. Our findings also open up a new door in drug and vaccine development that we never kn...Biodesign Institute leads innovative project to prevent cancer
...ntervention in history has been the development of vaccines against infectious disease. Developing a cancer vaccine would be the perfect solution, not only in eliminating cancer mortality, but also potentially some of the costs of diagnosis and treatment. The W.M. Keck Foundation Award will further push the...From clinical cancer research: rethinking therapeutic cancer vaccine trials
...cancer vaccine trials have yet to show evidence of vaccines spurring a patients immune system to shrink tumors -- yet patients who receive these vaccines in trials tend to live longer and respond better to subsequent treatment. In the July 1 issue of Cli...American Chemical Society's Weekly PressPac -- June 20, 2007
... already has yielded a bounty of new medicines and vaccines to keep Fido and Fluffy healthy and comfortable. Petkewich cites, for instance, the first diet drugs for dogs; the first approved drug for vomiting in dogs, including vomiting due to motion sickness or cancer chemotherapy; and a new medication for th...Tips from the Journals of the American Society for Microbiology
...as the common portal of pathogen entry, intranasal vaccines may prove vital in preventative therapies. In the study researchers developed a vaccine incorporating the human parainfluenza virus type 3 (HPIV3), a common pediatric respiratory pathogen, and administered it by respiratory route to rhesus monkeys....Fever after smallpox vaccination tied to individual genetic variations
...velop a fever over 99 degrees. Fevers related to vaccines are not considered a serious medical issue, but in rare cases they can lead to more severe complications. Individuals who get a fever after the smallpox vaccine occasionally develop myopericarditis, a potentially life-threatening inflammation of the ...How 'memory' T cells curb the spread of viruses throughout the body
...ecurrence of the same disease. This is why before vaccines were developed, childhood diseases such as measles...e body from recurrence of the disease. Similarly, vaccines induce the production of memory lymphocytes, but without causing disease. While scientists have long...Mucosal-surface immune function discoveries could boost vaccine research
...thogens helps us immensely when we try and develop vaccines that target these areas," he explains. "By taking advantages of these mechanisms, we should move that much closer to interventions that shield millions against potentially lethal infections."...Getting to the core of an emergent public health threat
...o make use of this basic research to design better vaccines and develop new targets for antiviral treatments." One of the well known characteristics of viruses is their uncanny ability to hijack the resources of its host. What made SARS such an alarming threat was that the symptoms were much more severe t...Tips from the Journals of the American Society for Microbiology
...ion of mosquito salivary components to antimalaria vaccines may be a viable strategy for creating a Th1-biased...s strategy may be important for the development of vaccines to combat other mosquito-transmitted pathogens." (M.J. Donovan, A.S. Messmore, D.A. Scrafford, D.L...Generic biologic drugs unlikely to offer significant savings
...s Fuqua School of Business. Biologics are drugs, vaccines and other medicines produced by living cells in controlled circumstances. The way they are made differs from traditional pharmaceutical drugs that are produced by industrial-scale chemistry. Insulin is a common biologic prescribed to treat diabetes...Pioneering research on sleeping sickness wins MERIAL Award for Parasitology
...roduction of TNF. To do this, they have formulated vaccines that target the components of trypanosoma that induce TNF production. Initial results in mice are very encouraging, and the researchers will test the medicine this year in Kenya, where the disease occurs primarily in cattle. Rewarding innovative r...