New version of tumor-suppressor linked to progression of childhood cancer
... L'Aquila in Italy found a previously undiscovered variant of TrkA, called TrkIII, which exhibits oncogenic properties in human NB cells. TrkIII levels are elevated in advanced stage NB tumors, suggesting that the molecule may play a role in cancer progression. The researchers found that the level of TrkIII ...Gene linked to greater risk of heart disease in type 2 diabetes
...d triglycerides occurred in people with a specific variant combination. Using this new knowledge as a basis f...there was a strong link: People with that specific variant combination in the CD36 gene were 60 percent more likely to have heart disease. "While this resear...Are yeast cells bringing us a step closer in treating obesity?
...ut that the proteins found in yeast have a similar variant in human cells. This makes yeast an excellent model organism for learning more about mechanisms in humans and animals. There has long been a question about whether mammals have glucose receptors. The discovery of such receptors in yeast considerably ...Scientists raise concerns about second wave of 'mad cow' prion infection
...ing evidence that infectious prions that can cause variant Creutzfeldt-Jakob Disease (vCJD), the human form of "mad cow" disease, can be transmitted through blood transfusion, according to Roger Eglin, Ph.D., Head of National Transfusion Microbiology Laboratories for the English National Blood Service. He sp...Research confirms that vCJD prions can be removed from blood
...rch results released today confirm that infectious variant Creutzfeldt-Jakob Disease (vCJD) prions that cause the human form of "mad cow disease" can be removed from blood. The study, presented today at the annual meeting of the AABB, found that a new filtration technology from Pall Corporation (NYSE: PLL) ...Molecular switch provides clues to remarkable adaptability of human pathogen
...inosa but are resistant to infection with a mutant variant of P. aeruginosa lacking RetS. Surprisingly, the less virulent P. aeruginosa with mutated RetS formed bacterial communities, called biofilms, much earlier than the normal bacteria. Formation of biofilms is associated with long-term chronic infectio...Pediatric cardiology researchers describe findings in neurologic outcomes, heart devices
...f they also had a genetic syndrome or a particular variant of a gene. Children with tetralogy of Fallot are born with multiple abnormal heart structures. Even with the heart defect, children without genetic syndromes tended to have normal neurodevelopmental scores one year after surgery. William Gaynor, M.D....Genetic variant linked to weakened heart pumping
... Center for Human Genetics, have discovered that a variant of a transcription factor crucial to the regulatio...nts, they said. The researchers linked the genetic variant to a reduction in the left ventricle's ejection fraction, a measurement cardiologists make of how mu...UCSD biologists identify gene in corn plants that may have paved way for development of maize
...us variants of this gene in teosinte, but only one variant of the gene in all inbred varieties of modern maiz...argeted selection of this particular barren stalk1 variant by humans was likely an important addition to the traits responsible for the development of modern m...Genetic defect confers risk of major depression, resistance to SSRI drug therapy
...ression." The genetic defect is the first genetic variant of functional consequence in the production of ser...ls of serotonin in mice, suggesting that the human variant of the gene might underlie psychiatric disorders characterized by low levels of the chemical messeng...Mutant gene linked to treatment-resistant depression
...ercent less serotonin. This suggested that such a variant gene might also exist in humans and might be invol...ty to neurons. In the current study, a similar variant culled from human subjects produced 80 percent less serotonin in cell cultures than the common versi...A genetic difference at the opiate receptor gene affects a person's response to alcohol
... New findings indicate that individuals with the G variant of the A118 polymorphism of the OPRM1 gene have gr...tal Research indicate that individuals with the G variant of the A118 polymorphism of the OPRM1 gene have greater subjective feelings to alcohol's effects as ...Stowers researcher publishes DNA double-strand break repair discovery in Science
... tumor suppressors including a specialized histone variant called H2A.X/v. H2A.X/v itself becomes phosphorylated by a DNA damage- recognizing factor in the proximity of DNA double-strand breaks. This finding raised the possibility that the complex, which was called the dTip60 complex, might specifically be a...Research finds genetic link to antidepressants
... that depressed and highly anxious patients with a variant of the CRH gene (CRHR1) had a 70 percent greater reduction in anxiety and a 30 percent greater reduction in depression in response to the anti-depressants Prozac and desipramine than did patients without the gene variation in question. IMPACT: The ...Genetic polymorphisms, antidepressant use may be associated with altered tamoxifen activity
...rapy, women carrying one or two copies of a CYP2D6 variant allele had lower plasma concentrations of endoxifen (an active tamoxifen metabolite) than women with the homozygous wild-type genotype. Among women carrying two copies of the wild-type CYP2D6 allele, the plasma endoxifen concentration was 58% lower i...Can plant research lead to new insights in cancer research?
...opsis plant. The scientists suspect that the human variant of this protein, E2F7, performs the same essential function in human cells. Their research is bringing to light a potentially new class of genes that can suppress the growth of tumors. Loss of control... Our body is constructed of cells that contai...Increased risk of osteoporosis associated with gene that one in five people have
...dicine in St. Louis demonstrated that in women the variant gene speeds up the breakdown of estrogen and is as...ta showed a strong correlation between the genetic variant and low bone density." The research team measured bone density in both the spine and the upper femur...Removing prions that cause mad cow in humans from blood
...5) - - Assessing the risk of potential exposure to variant Creutzfeldt-Jakob Disease (vCJD), the human form of 'mad cow disease,' from blood transfusion was the focus of the Food & Drug Administration (FDA) Transmissible Spongiform Encephalopathies (TSEs) Advisory Committee in Silver Spring, Maryland today. ...Hypertension in African Americans linked to two genomic regions
...enes affecting hypertension. "When a specific gene variant associated with hypertension is identified, physicians will be able to test patients for their risk of hypertension to head it off early," Rao says. "In addition, research institutions and pharmaceutical companies can develop new drugs that compensat......f complex diseases. TITLE: IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation AUTHOR CONTACT:Donata Vercelli University of Arizona, Tucson, Arizona USA Phone: (520) 626-6387; Fax: (520) 626-6623; E-mail: donata@arc.a...