Tag: "variant" at biology news

Inherited gene may increase risk for prostate cancer by 50%

A single gene variant may increase a man's risk of prostate cancer by 50...y. The significant difference in prevalence of the variant among three groups indicates that individuals with this particular gene variant face an approximatel...

Map of human genetic variation across populations may promise improved disease treatments

...ts, Jasny explained, the greater the odds that one variant may be recombined or shuffled out of the sequence ...the researchers, some 1,586,383 were found in both variant forms, or alleles, among the 71 DNA samples. Because 157,000 of the SNPs and nine individuals from ...

MGH study identifies potential Alzheimer's risk gene

...generative Disorders (MIND) have identified a gene variant that may increase the risk of late-onset Alzheimer...entive and treatment strategies. "We believe this variant moderately but significantly raises the risk of Alzheimer's disease," says Lars Bertram, MD, of the ...

Gene variant increases risk of age-related macular degeneration

...ment and legal blindness in the elderly. A common variant of the gene, called complement factor H (CFH), exp...duals with one or more copies of a particular gene variant were more likely to have AMD compared to those with other versions of the gene, they reported. When ...

Histamine, anxiety and alcoholism

... in examining the role of the functional Thr105Ile variant of HNMT because this is the enzyme which accounts ...most important message is that a common functional variant of a histamine-metabolizing enzyme in the human brain may be able to influence behavior and individu...

Antioxidant blood levels key to MnSOD gene

...ve stress. Conversely, if carriers of this genetic variant have low levels of these vitamins and minerals, their risk of aggressive prostate increases substantially, as great as 10-fold, over their cohorts who maintain higher levels of these nutrients. These results, published in the March 15 issue of the jo...

Mutant protein developed by Hebrew University scientists

...ids with others, they were able to create a leptin variant that could bind with cell receptors, but would be unable to activate them, thereby providing a unique, novel research tool. In this way, the mutated leptin, with the substituted amino acids, acts as an "antagonist," competing with the normal leptin f...

Pall prion removal technology presented to FDA blood products advisory committee

...ible Spongiform Encephalopathies (TSEs), including variant Creutzfeldt-Jakob Disease (vCJD), the human form of "mad cow" disease, was a key topic at the Food & Drug Administration's Blood Products Advisory Committee meeting in Gaithersburg, Maryland today. Issues such as the number of people that could be ha...

Researchers trace evolution to relatively simple genetic changes

...nments, he added, "we wondered whether the genetic variant (the mutant gene) that controls this trait might s...mor, and we found a very low level of this genetic variant in the marine population." So, he said, "the marine fish actually carry the genes for this alternat...

UT Southwestern researchers uncover gene variant that appears to predict type 2 diabetes

DALLAS March 25, 2005 A particular gene variant that could serve as a predictor for type 2 diabete...d, researchers said these results suggest that the variant may serve as an important genetic marker in identifying people at risk for type 2 diabetes. "This im...

Gene variations explain drug dose required to control seizures

...he drugs and variation in the candidate genes. One variant of a gene known as CYP2C9, which encodes a liver e...ytoin taken by patients with epilepsy. Moreover, a variant of a second gene, called SCN1A, with activity in the brain, was found significantly more often in pa...

Fibril shape is the basis of prion strains and cross-species prion infection

...ed to tainted beef products, but very few cases of variant Creutzfeld-Jakob." He says there "must be protective mechanisms working there, but we don't know what they are."...

Extending genetic associations with risk for alcohol dependence to a Russian population

...base pairs; about every 100 base pairs, there is a variant that is different between individuals. We believe...k, behave and respond to medications is encoded in variant sites in genes." Lappalainen and his colleagues found significant associations between two SNPs and...

Examining the serotonin transporter gene and family function

... relations may have on adolescent drinking. Both a variant of the 5-HTT gene and poor family relations, as we...Specifically, adolescents with the LS (long/short) variant of the 5-HTT gene and with family relations rated as "neutral" or "bad" had a 12- to 14-fold increas...

Readers of genome decipher signatures of cancer patient outcomes

...f 51.3 months, compared to 25.37 months for the AA variant patients. "Perhaps the most significant finding f...study of MTHFR was that the combination of the two variant alleles was associated with significantly reduced risks of recurrence and death," Wu said. "This joi...

Genes influence how heart failure patients respond to drugs

...od example of how a functionally important genetic variant can alter therapeutic responses, and how such effects could be exploited in treatment strategies as well as the drug development process."...

Brain scans reveal how gene may boost schizophrenia risk

...tional Institute of Mental Health (NIMH). The gene variant produced a telltale pattern of activity linked to production of a key brain messenger chemical. The study found that increased activity in the front of the brain predicted increases in the neurotransmitter dopamine in the middle of the brain in subj...

Variation in immune response gene causes age-related macular degeneration when triggered

...population. But not everyone who has this genetic variant gets AMD, so what causes this mechanism to activate? "We believe inflammation from infections might kick start the process that leads to AMD," said Dr. Hageman. "The variation in Factor H strengthens the immune response, keeping infections under con...

Gene implicated in chronic kidney disease

...gene, the team reported. Further study of the gene variant in kidney cell cultures found that the mutation enhances the activity of the channels in response to angiotensin II, a protein known to promote high blood pressure and kidney injury, Winn said. While TRPC6 mutations have yet to be reported in other f...

Depression gene may weaken mood-regulating circuit

...ve emotion. People with the depression-linked gene variant showed less gray matter and weaker connections in ...ported studies had shown that inheriting the short variant more than doubles risk of depression following life stresses,** boosts amygdala activity while viewi...

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(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
(Date:12/5/2014)... PROVO, Utah , Dec. 4, 2014  Tute ... has raised $2.3 million in Series A1 funding led ... angel investors also participated in the investment round. ... as the healthcare community adopts next-generation sequencing and seeks ... disease," said Reid Robison , MD MBA, and ...
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... York College, and one of the most prolific inventors ... that are transmitted from Smartphones to third party agencies. ... and has one of the earliest known patents in ... usage in the military, child care, elder care and ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
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