Tag: "variant" at biology news
Inherited gene may increase risk for prostate cancer by 50%
A single gene variant
may increase a man's risk of prostate cancer by 50...y. The significant difference in prevalence of the variant
among three groups indicates that individuals with this particular gene variant
face an approximatel...
Map of human genetic variation across populations may promise improved disease treatments
...ts, Jasny explained, the greater the odds that one variant
may be recombined or shuffled out of the sequence ...the researchers, some 1,586,383 were found in both variant
forms, or alleles, among the 71 DNA samples. Because 157,000 of the SNPs and nine individuals from ...
MGH study identifies potential Alzheimer's risk gene
...generative Disorders (MIND) have identified a gene variant
that may increase the risk of late-onset Alzheimer...entive and treatment strategies. "We believe this variant
moderately but significantly raises the risk of Alzheimer's disease," says Lars Bertram, MD, of the ...
Gene variant increases risk of age-related macular degeneration
...ment and legal blindness in the elderly. A common variant
of the gene, called complement factor H (CFH), exp...duals with one or more copies of a particular gene variant
were more likely to have AMD compared to those with other versions of the gene, they reported. When ...
Histamine, anxiety and alcoholism
... in examining the role of the functional Thr105Ile variant
of HNMT because this is the enzyme which accounts ...most important message is that a common functional variant
of a histamine-metabolizing enzyme in the human brain may be able to influence behavior and individu...
Antioxidant blood levels key to MnSOD gene
...ve stress. Conversely, if carriers of this genetic variant
have low levels of these vitamins and minerals, their risk of aggressive prostate increases substantially, as great as 10-fold, over their cohorts who maintain higher levels of these nutrients. These results, published in the March 15 issue of the jo...
Mutant protein developed by Hebrew University scientists
...ids with others, they were able to create a leptin variant
that could bind with cell receptors, but would be unable to activate them, thereby providing a unique, novel research tool. In this way, the mutated leptin, with the substituted amino acids, acts as an "antagonist," competing with the normal leptin f...
Pall prion removal technology presented to FDA blood products advisory committee
...ible Spongiform Encephalopathies (TSEs), including variant
Creutzfeldt-Jakob Disease (vCJD), the human form of "mad cow" disease, was a key topic at the Food & Drug Administration's Blood Products Advisory Committee meeting in Gaithersburg, Maryland today. Issues such as the number of people that could be ha...
Researchers trace evolution to relatively simple genetic changes
...nments, he added, "we wondered whether the genetic variant
(the mutant gene) that controls this trait might s...mor, and we found a very low level of this genetic variant
in the marine population." So, he said, "the marine fish actually carry the genes for this alternat...
UT Southwestern researchers uncover gene variant that appears to predict type 2 diabetes
DALLAS March 25, 2005 A particular gene variant
that could serve as a predictor for type 2 diabete...d, researchers said these results suggest that the variant
may serve as an important genetic marker in identifying people at risk for type 2 diabetes. "This im...
Gene variations explain drug dose required to control seizures
...he drugs and variation in the candidate genes. One variant
of a gene known as CYP2C9, which encodes a liver e...ytoin taken by patients with epilepsy. Moreover, a variant
of a second gene, called SCN1A, with activity in the brain, was found significantly more often in pa...
Fibril shape is the basis of prion strains and cross-species prion infection
...ed to tainted beef products, but very few cases of variant
Creutzfeld-Jakob." He says there "must be protective mechanisms working there, but we don't know what they are."...
Extending genetic associations with risk for alcohol dependence to a Russian population
...base pairs; about every 100 base pairs, there is a variant
that is different between individuals. We believe...k, behave and respond to medications is encoded in variant
sites in genes." Lappalainen and his colleagues found significant associations between two SNPs and...
Examining the serotonin transporter gene and family function
... relations may have on adolescent drinking. Both a variant
of the 5-HTT gene and poor family relations, as we...Specifically, adolescents with the LS (long/short) variant
of the 5-HTT gene and with family relations rated as "neutral" or "bad" had a 12- to 14-fold increas...
Readers of genome decipher signatures of cancer patient outcomes
...f 51.3 months, compared to 25.37 months for the AA variant
patients. "Perhaps the most significant finding f...study of MTHFR was that the combination of the two variant
alleles was associated with significantly reduced risks of recurrence and death," Wu said. "This joi...
Genes influence how heart failure patients respond to drugs
...od example of how a functionally important genetic variant
can alter therapeutic responses, and how such effects could be exploited in treatment strategies as well as the drug development process."...
Brain scans reveal how gene may boost schizophrenia risk
...tional Institute of Mental Health (NIMH). The gene variant
produced a telltale pattern of activity linked to production of a key brain messenger chemical. The study found that increased activity in the front of the brain predicted increases in the neurotransmitter dopamine in the middle of the brain in subj...
Variation in immune response gene causes age-related macular degeneration when triggered
...population. But not everyone who has this genetic variant
gets AMD, so what causes this mechanism to activate? "We believe inflammation from infections might kick start the process that leads to AMD," said Dr. Hageman. "The variation in Factor H strengthens the immune response, keeping infections under con...
Gene implicated in chronic kidney disease
...gene, the team reported. Further study of the gene variant
in kidney cell cultures found that the mutation enhances the activity of the channels in response to angiotensin II, a protein known to promote high blood pressure and kidney injury, Winn said. While TRPC6 mutations have yet to be reported in other f...
Depression gene may weaken mood-regulating circuit
...ve emotion. People with the depression-linked gene variant
showed less gray matter and weaker connections in ...ported studies had shown that inheriting the short variant
more than doubles risk of depression following life stresses,** boosts amygdala activity while viewi...
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