Tag: "variant" at biology news

Evolution follows few of the possible paths to antibiotic resistance

...penicillin and cefotaxime. Analyzing how well each variant protected host Escherichia coli cells against trea...n contrast, most mutational paths of the enzymatic variant we examined fail to continuously increase resistance. Importantly, this is not a reflection of the f...

Research updates 65-year-old genetic discovery

...tistician and geneticist, concluded that this gene variant was the same in humans and chimpanzees and existed...n't have the same change in the middle of the gene variant as humans, but rather have a change at the start." Both changes in the sequences cause this bitter t...

Gene variant associated with obesity risk found with new statistical technique

...des an unusually strong association between a gene variant and a complex disease in the field of association ...14 issue of Science. The scientists identified the variant by testing 86,604 single nucleotide polymorphisms (SNPs), or DNA sequence variations, for an associa...

Natural selection at single gene demonstrated

...nts over 1,102 short fragments of the genome. Each variant was assigned a score based on the similarity of tw...The higher the score, the less likely it is that a variant could have arisen and spread randomly. The scoring formula accounts for the greater similarity expec...

Gene variant protects against type 2 diabetes, heart disease, and hypertriglyceridemia

Boston, MA -- A rare gene variant in humans helps to protect against two of the coun...Academy of Sciences. Individuals who had the gene variant had 12 percent lower levels of triglycerides in their blood serum than subjects who did not have the...

Feinstein researchers identify intelligence gene

... general cognitive ability in carriers of the risk variant compared with non-carriers in two independent grou...was significantly impaired in carriers of the risk variant in both the schizophrenia group and the healthy volunteers as compared with the non-carriers. "While...

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

...ics on April 30. "In addition to finding a genetic variant that could be of clinical value for sudden cardiac death, this study also demonstrates how valuable large-scale genomics studies can be in detecting novel biological targets," says the study's senior author, Aravinda Chakravarti, Ph.D., director of t...

Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype

...lls. One suggested explanation of why this genetic variant remains in the population despite being associated with anemia is that it may provide protection from life-threatening malaria. In a related perspective, Stephen Rogerson from the Royal Melbourne Hospital discusses further the implications of the stu...

Children's Hospital Boston presents at the 2006 Pediatric Academic Societies annual meeting

... found an association between obesity and a common variant of a gene known as INSIG2 (insulin-induced gene 2). Drs. Helen Lyon and Joel Hirschhorn from Children's Hospital Boston and the Broad Institute, along with collaborators at Loyola University in Chicago, HSPH and other institutions, have now replicate...

Five Spanish hospitals in international phase III trial with H5N1 influenza pandemic vaccine

...ture of the several influenza virus identifies the variant they contain of the two more important genes involved in the infection. The Haemaglutinin (H) gene is related with the infectiousness and the virulence of the virus, whereas the Neuraminidase (N) gene determines the ability of progression of the infe...

Scientists discover two genes linked to early heart attack risk

...k thus far. He suspects that the newly discovered variant of VAMP8 either speeds the clotting process, triggers it too early or allows clotting to continue too long. "We are now eager to screen the population for people with two copies of this gene and study its action at the molecular level," Kane said. "V...

Chimpanzee study reveals genome variation hotspots

...irst step in studying the evolution of copy number variant regions and their downstream implications for disease and phenotypic variation," Perry says. In the study, researchers looked at the structural genomic variation in DNA samples of 20 wild-born male chimpanzees. "We identified 355 copy number variants...

Is brain size linked to two common gene variants?

...The researchers found no evidence that either gene variant was related to increases or decreases in brain siz...rpreting evidence that nature has favored one gene variant over another during human evolution. Incorrect interpretations may lead to inaccurate assumptions ab...

Ready, set, mutate and may the best microbe win

... about 700 of those were capable of creating a new variant of the target gene. In all, the researchers identified 343 unique strains, each of which contained one of just six variants of the critical gene. The first of the six, dubbed Q199R, arose almost immediately, and was the dominant strain through the 50...

Genes raise risk of heart disease after treatment for childhood cancer

...polymorphism increased risk by five times; another variant was linked to a tripling of risk. The research group chose particular genes as candidates for study because those genes carry the codes for enzymes involved in metabolizing anthracyclines and the reactive oxygen molecules that anthracyclines produc...

Large-scale genomics project will hunt genes behind common childhood diseases

... the five percent of people with a particular gene variant for a disease, but also the larger percentage who suffer the disease without having that variant." To accomplish the large-scale genotyping analysis, the Center for Applied Genomics at Children's Hospital will use the BeadLab, a highly automated lab...

Breast cancer genetics and more -- press release from PLoS Medicine

...he Creative Commons Attribution License. Genetic variant of BARD1 and risk of breast cancer in Iceland A variant -Cys557Ser- of a gene called BARD1 may have a role in triggering breast cancer in some women. A team...

Scientists develop a new diagnostic approach for carriers of recessive genetic disorders

...s who possess only one copy of the causative gene variant appear normal, although some reports have suggested that heterozygotes may have an increased risk of cancer. Using microarray technology, which simultaneously ascertains the expression patterns of thousands of genes, Cheung and Ewens discovered th...

Other highlights in the July 5 JNCI

...en with the common variation of SNP309 but not the variant form of SNP309. Contact: NCI Press Officers, 301-496-6641, NCIPressOfficers@mail.nih.gov Also in the July 5 JNCI: Design of Nonpeptidic Topomimetics of Antiangiogenic Proteins With Antitumor Activities Childhood Cancer Survivors Are...

Prion find points way to test for human 'mad cow' disease

... transmission of the malformed proteins that cause variant Creutzfeldt-Jakob disease (vCJD) via blood transfu...al biochemical test that will determine how common variant CJD is, and keep contaminated blood and organs from spreading it further." Creating such a test is...

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