Tag: "variants" at biology news
Commandeering cellular machinery: recognition mechanism to detect small molecules
...known as chemical complementation that allowed the variants
to be tested in parallel a task akin to finding genetic needles in thousands of haystacks simultaneously. Using the technique, the researchers placed each variant, which had been inserted into yeast cells, onto petri plates containing LG335. A sm...
NIH funds first nationaL SNP genotyping center at Broad Institute
... analytic tools for analysis of correlations among variants
and with disease phenotypes. Because investigators use different technologies based on the scales and configurations needed, a menu of services will be offered using three different technology platforms. When fully operational, the center will be ab...
Laboratory test of evolutionary theory confirms importance of links between populations
...term "gene flow" to describe the spread of genetic variants
that accompanies the movements of individuals. This study provides the first direct empirical evidence that gene flow across a heterogeneous landscape can alter the dynamics of coevolution. "By working with microbes that go through about ten generat...
Gene linked to greater risk of heart disease in type 2 diabetes
... beads on a spiral necklace. They were looking for variants
in this sequence that are associated with increase... free fatty acids and triglycerides. When all five variants
were factored together, a strong link emerged -- the highest levels of fatty acids and triglycerides...
International human genome sequencing consortium describes finished human genome sequence
...human genome that may contain small and often rare variants
involved in disease. "Finished" doesn't mean that the human genome sequence is perfect. There still remain 341 gaps in the finished human genome sequence, in contrast to the 150,000 gaps in the working draft announced in June 2000. The technology n...
'Broken' gene reveals evolution of salt retention and possible ties to hypertension
...h CYP3A5 *3. This correlation of two unlinked gene variants
with similar effects, "is remarkable," the authors note, "and suggests a shared selective pressure." The National Institutes of Health funded this study through the Pharmacogenetics Research Network. Additional authors include E. E. Thompson, H. Kut...
Stress impairs thinking via mania-linked enzyme
...ts. Susceptibility to bipolar disorder may involve variants
of genes that code for a key PKC precursor and for a stress-sensitive signaling protein that normally puts the brakes on PKC activity. The new study shows how PKC triggers cognitive symptoms in response to stress. When the stress-sensitive messenger ...
JCI table of contents November 1, 2004
...0361.pdf ACCOMPANYING COMMENTARY: Do DNA sequence variants
in ABCA1 contribute to HDL cholesterol levels in the general population? AUTHOR CONTACT: Pivi Pajukanta University of California, Los Angeles, 695 Charles E. Young Dr South, Los Angeles, CA 90095, USA Phone: 310-267-2011; Fax: 310-794-5446; E-mail: ...
Genetic variant linked to weakened heart pumping
...ue plans future studies to determine whether other variants
of PPAR are also involved in declining heart function. Ultimately, he hopes genetic research will help physicians predict at an early stage which patients are at greatest risk for developing heart failure, and to treat them more effectively....
Brain-derived neurotrophic factor (BDNF) appears to modify elements of alcoholism
...F) on the dopamine system. Findings indicate that variants
of the BDNF gene may not only play a role in a per...: Clinical & Experimental Research, suggest that variants
of the BDNF gene may not only play a role in a person's committal of violence while intoxicated, but...
Racial disparities noted in immune system genes
PITTSBURGH, Dec. 1 Specific variants
in genes that encode proteins regulating inflammat...ns were significantly more likely to carry genetic variants
known to stimulate the inflammatory response," said Roberta B. Ness, M.D., M.P.H., professor and cha...
UCSD biologists identify gene in corn plants that may have paved way for development of maize
... The researchers say the presence of numerous variants
of this gene in teosinte, but only one variant of ...nt, Qiong Zhao, the two scientists found that many variants
of the gene exist in teosinte, yet only one was incorporated into modern maize inbreds. This led the...
Genetic defect confers risk of major depression, resistance to SSRI drug therapy
...he researchers further suggest that this and other variants
of the gene might also explain such paradoxical ad...n's team reported earlier this year that different variants
of that enzyme have a major effect on brain levels of serotonin in mice, suggesting that the human v...
Permanent resistance to antibiotics cannot be prevented
...ster-growing non-resistant counterparts. Yet, some variants
remain permanently resistant. Permanent resistance occurs in two stages. The fungus first of all becomes resistant due to a change in its DNA and then a second such change ensures that the resistant type eventually grows just as quickly as the non-r...
An unusual RNA structure in the SARS virus offers a promising target for antiviral drugs
...ies. Furthermore, an analysis of 38 different SARS variants
found absolutely no variation within the s2m sequence. Other scientists had previously noticed this highly conserved element in astroviruses and a few other viruses, and had given it the s2m name. But no one had any idea what the s2m RNA does that w...
Flame retardant exposure linked to house dust
...oth dust from floors and clothes dryer lint for 22 variants
of commercial PBDEs and found PBDEs in every sample. Interestingly, there was little correlation between PBDE levels and the age of the dwelling or the number of foam cushions or appliances, but smaller dwellings tended towards higher concentrations ...
Genetic polymorphisms, antidepressant use may be associated with altered tamoxifen activity
...ses. It is possible that testing of CYP2D6 genetic variants
and careful attention to use of CYP2D6 inhibitors may help identify a group of women who may experience greater benefit from tamoxifen and/or who might benefit more from treatment with one SSRI over another. Firm clinical recommendations about which ...
Scientists discover key genetic factor in determining HIV/AIDS risk
...1 copy number along with disease-accelerating CCR5 variants
had an even higher risk of HIV acquisition and rate of progression to AIDS. "This work adds significantly to our understanding of the central role that molecules that interact with the CCR5 co-receptor play in influencing susceptibility to HIV/AIDS,"...
Increased risk of osteoporosis associated with gene that one in five people have
...veral variations of the CYP1A1 gene exist, and the variants
differ from one another by one or more DNA base pairs. "Previous studies showed that some CYP1A1 variants
are linked to estrogen-related cancers, such as breast, ovarian or endometrial cancers," says Reina ...
McGill researcher looks at the genetics behind cheese
.... According to Ng, in addition to the two genetic variants
for kappa casein mentioned above, there are about 50 known milk protein gene variants
and they have diverse effects on dairy product production. These findings have generated a great in...
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