Einstein researchers' prototype vaccine could provide improved protection against tuberculosis
...accine is the wrong strategy. So weve started with virulent M. tuberculosisthe organism that actually causes TB in humansand are knocking out certain genes to yield a live, attenuated M. tuberculosis strain that still produces a strong immunological response that protects people. TB bacteria invade human ce...Other highlights in the July 24 JNCI
...cer. Aggressive prostate cancer is biologically virulent and associated with poor prognosis. Therefore, if the association that we observed is ultimately found to be causal, a possible means to reduce the burden of this disease may be primary prevention through increased consumption of broccoli, cauliflowe...CRESIB coordinates an international consortium to fight malaria caused by Plasmodium vivax
...ivax are the most prevalent, the first being more virulent and responsible of most of the severe morbidity and mortality. Nevertheless, during the last years, there has been a growing interest in malaria by P. vivax , which, as well as causing millions of malaria cases every year, it also generates a high s...Clues to future evolution of HIV come from African green monkeys
...ch that suggests HIVs from the late 1980s are more virulent than HIVs from the 2000s, Worobey added, "For HIV, the really cool thing is that these changes can take place on a more rapid timeline that previously thought." Wertheim adds, "Understanding how emerging infectious diseases evolve in their natural ...Tips from the Journals of the American Society for Microbiology
... U.S. alone. The recent emergence of a new highly virulent strain has increased the need for effective preventative treatment methods. Toxins A and B are the two major virulence factors expressed by C. difficile. Toxin A initiates infection allowing toxin B to access underlying cells. In the study resear...Understanding why C. difficile causes disease -- it's hungry
... inflammations of the colon. In 2002 a new, more virulent strain began appearing in hospitals in the United ...in a representative sampling in Quebec. The highly virulent strain has a much higher toxin production which leads to more destructive and deadly disease, says V...How plague-causing bacteria disarm host defense
...sponsible for the Middle Ages' "Black Death" and a virulent form of food poisoning today. Their study will be published online in the May 25 issue of Molecular Cell. YpkA targets a host protein called Gaq, the messenger that transmits extracellular signals ("we are under attack!") into the host cell, so th...Salt increases ulcer-bug virulence
...sing bacterium Helicobacter pylori, making it more virulent and increasing the likelihood of an infected person developing a severe gastric disease. "Apparently the stomach pathogen H. pylori closely monitors the diets of those people whom it infects. Epidemiological evidence has long implied that there is...Plant pathologists fighting global threat to wheat supply
...it all but disappear. Despite this success, a new, virulent strain of wheat stem rust, Ug99, evolved in Uganda and has already spread into Kenya, Ethiopia and Yemen, with the potential to spread into Pakistan, India, and China, and eventually North America. "This new race could attack wheat varieties in ma...Researchers create interactive map with Google technology to track avian flu spread
..., and neuraminidase, or NA. Scientists think if a virulent strain of H5N1 adapts to succeed at human-to-human transmission, it would likely involve mutations by the two proteins, said Guralnick. No mutations associated with NA and HA were linked to any specific bird or mammal host, he said. But the team ...A new study links a stomach microbe to asthma prevention
... of a health survey of 7,663 adults, showed that a virulent strain of H. pylori was especially associated with...iation with ever having had asthma. Those with the virulent strain were 20 percent less likely to have ever had asthma compared with participants without H. pyl...Migratory birds: Innocent scapegoats for the dispersal of the H5N1 virus
...favourable for the maintenance and transmission of virulent agents, in particular subtypes of highly pathogenic influenza. Paradoxically, the H5N1 virus coupled with a fear of transmission by wild birds could lead to a reversion to battery farming which increases risk of outbreaks. This would stall the curren...Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu
...nto the interactions among factors determining how virulent a particular type of flu might be, and this will require a lot of raw computing power," said Maqsudul Alam, director at the Advance Studies in Genomics, Proteomics and Bioinformatics, College of Natural Sciences, University of Hawaii. "This will allo...Rickettsia felis, a cat-fleaborne pathogen, sheds light on Rickettsial evolution
...he development of diagnostics and vaccines for the virulent rickettsial pathogens. The work has been carried ...pen up exciting new research opportunities for the virulent rickettsiae. One of the goals of the PATRIC project is to enable the future development of much need...Bats prey on nocturnally migrating songbirds
...rogramme was soon joined by one of their once most virulent Swiss detractors (Prof. Raphal Arlettaz, University of Bern and Swiss Ornithological Institute). The technique of stable isotopes was applied because this recently developed method allows tracking species' main dietary specializations and trophic lev...JCI table of contents: Jan. 18, 2007
...sis. One of the things that makes P. aeruginosa so virulent is the expression of a number of proteins that function as a type III secretion system. In a study that appears online on January 18 in advance of publication in the February print issue of the Journal of Clinical Investigation, researchers from the ...Study uncovers a lethal secret of 1918 influenza virus
...mmune response may be a shared feature of the most virulent influenza viruses. In the new study, conducted in...s, suggesting the agent somehow sets the stage for virulent infection: "Somehow, early in infection, this virus does something to the host that allows it to gro...Dangerous wheat disease jumps Red Sea
...yria, -- 16 Jan 2007 -- A new form of stem rust, a virulent wheat disease, has jumped from eastern Africa and ...and India. There is precedence for this, from a virulent strain of another wheat disease, called yellow rust, which emerged in eastern Africa in the late 198...Wheat can fatally starve insect predators
...may make several strains of lectins in response to virulent larvae, Williams said. Results of the study are ...ian fly larvae attack, she said. In addition, some virulent larvae can reprogram plant development so that cells in leaves and the base of the plant where the i...... hatching. When hatched chicks were exposed to the virulent M41 strain, we observed protection rates of up to 100 percent. With the UK poultry industry sustaining losses of 23.6M a year to infectious bronchitis virus we hope that our research could have a real impact on improving yields for UK farmers." "We...