Research team develops nonhuman primate model of smallpox infection
...s concern that undisclosed reference stocks of the virus may exist, and the U.S. population is no longer ro...n in monkeys that received the same dose of either virus by the intravenous route alone. Having demonstrated that it was possible to achieve lethal infectio...Viruses found in untreated city water
...trating city wells was related to the frequency of virus detection in the wells. "There is a miscon...es contained at least one type of gastrointestinal virus and 23 percent of the samples contained two or more virus types.The study found enteroviruses, rotav...After flu exposure, mild exercise protects mature mice from dying
... mice 11-20 weeks old were infected with influenza virus and then randomly assigned to exercise (EX) or home cage control (HCC). The EX mice were exercised for 20 to 30 minutes for four days and multiple subjective and standard measurements were recorded. "The animals did very moderate exercise while they ...HHS awards $232 million in biodefense contracts for vaccine development
...nd. MVA is a highly weakened form of the vaccinia virus that cannot replicate in human cells. Previous NIAID research has demonstrated that MVA is nearly as effective as the standard smallpox vaccine, making it a promising candidate for use in children and pregnant women as well as people with weak...New study on smallpox in monkeys reveals tactics of a killer
...glimpse of how, on a molecular level, the smallpox virus attacks its victims. The findings shed light on how the virus caused mass death and suffering, and will help point the way to new diagnostics, vaccines and drugs ...Technique for genetically modifying blood stem cells brings cure for blood diseases closer
...is protein. The vector, which used a virus called lentivirus to carry the gamma-globin gene, also carried a special set of additional pieces of DNA called regulatory elements. These elements were part of a section of the normal chromosome containing the globin locus control region (LCR), whic...Tips from the Journals of the American Society for Microbiology
...apable of inducing protection against heterologous virus strains and should induce long-lived responses and... mice challenged with two strains of the influenza virus were immunized with the pDNA vaccine and administered tucaresol. Researchers found that the combina...Laboratory test of evolutionary theory confirms importance of links between populations
...a common type of bacteria, Escherichia coli, and a virus that infects it, called bacteriophage T7. The rese... track adaptations that arose in both bacteria and virus populations and show that the pattern of adaptations depended on both the environment in which the o...Experimental drug prevents vaginal simian HIV transmission in monkeys Science study says
...15 minutes before exposure to the immunodeficiency virus SHIV and report that the drug protected the animal...ins the inner parts of the simian immunodeficiency virus (SIV) and the outer parts of HIV. This study is published in the 15 October issue of the journal Sc...Study identifies target for preventing sexual transmission of HIV
...ut there has been substantial debate as to how the virus actually gets into cells at these sites of transmi...tect rhesus macaques from vaginal challenge with a virus like HIV. A natural immune messenger (chemokine) called RANTES can bind to CCR5 and by binding, for...Pushing the envelope to overcome HIV drug resistance
...changes in the substrate would be required for the virus to survive. However, research from the lab of Celia Schiffer at the University of Massachusetts Medical School has revealed a common structural theme in protease inhibitor resistance. By comparing the structures of several substrate-protease complexe...Hepatitis C virus linked to non-Hodgkin's lymphoma
SEATTLE--Patients infected with the hepatitis C virus (HCV) are six times as likely to develop non-Hodgkin's lymphoma (NHL) than individuals that are virus free, according to research presented today at the Third Annual Frontiers in Cancer Prevention Resea...NIH funds new bioinformatics resources at UT Southwestern
...arch related to how microbes such as the influenza virus and the tuberculosis bacterium, Mycobacterium tuberculosis, establish infections and how the body responds to them. A pathogen, such as the tuberculosis bacterium, interacts with cells in the host's body, leading to changes in gene and protein activi...Gene therapy approach reverses diabetic neuropathy in animal model, Pitt study finds
...eam designed vectors of inactivated herpes simplex virus (HSV), which normally infects sensory neurons. The... (NFG) and neurotrophin-3 (NT-3). "Herpes simplex virus appears to be an ideally suited gene therapy vector for diabetic neuropathy, in part because very li...Trojan-horse therapy blocks buildup of Alzheimer's plaque
...thogenic organisms, such as human immunodeficiency virus (HIV). Led by Howard Hughes Medical Institute inve...nly to a few amino acids in the protein, which the virus can easily alter by mutation. But in our approach, we could distribute the binding over a large prot...Gene linked to enlargement of the factory where proteins are processed
...ibroblasts. They inserted the gene for XBP1 into a virus and used the genetically modified virus to transfer the gene into the fibroblasts. The XBP1 gene triggered an increase in the activity of ke...Researchers uncover how infections combat plant immune responses
...is a recently discovered defense mechanism against virus infection in plants and invertebrates. For success...se. "Our results demonstrate that citrus tristeza virus (CTV) produces three proteins that are suppressors of RNA silencing and each inhibits RNA silencing ...U-M researcher examines the cell's housekeeping habits
...athogens try to escape autophagy. For example, the virus that causes Herpes carries a gene that blocks autophagy. The bacteria that cause Legionnaire's Disease actually hide inside the vesicles to reproduce. Autophagy may even provide a clue to the mythical fountain of youth. Autophagy activity is known ...Tiny paddle oscillator senses the mass of a virus
...quencies in the neighborhood of 10 megaHertz. The virus used in the experiment weighs about 1.5 femtograms...gram is 1/1000th of a picogram.) Adding just a few virus particles to a paddle turns out to be enough to change its resonant frequency by about 10 kiloHertz ......omparison, birds in North America spread West Nile virus across the continent at about 1,000 kilometers a year. The findings, the Frontiers authors write, "suggest that pathogens may pose a particularly severe problem in the ocean." The Trends paper ("Does terrestrial epidemiology apply to marine syste...