JCI Table of contents August 1, 2005
...ellier provide the first report of a successful in vivo transcriptionally-targeted gene therapy for this g...T cell-specific lentiviral vector, avoiding any ex vivo manipulation that usually results in functional problems. This results in the presence of gene-modif...Critical step traced in anthrax infection
...e tried to bridge reductionist science with the in vivo situation ?we have to do both to make correlations," he said. The researchers, who were funded by the National Institutes of Health and the National Science Foundation, will continue to study protein unfolding in translocation during anthrax infectio...New method shows it is possible to grow bone for grafts within a patient's body
...ue engineering, is described in a paper titled "In vivo engineering of organs: The bone bioreactor" publis...ind that this zone, which they have dubbed the "in vivo bioreactor," filled healthy bone in about six weeks. And it did so without having to coax the bone t...Using nanoparticles, in vivo gene therapy activates brain stem cells
...at a non-viral vector has demonstrated efficacy in vivo at levels comparable to a viral vector," Bharali s... in the brain. Using a new optical fiber in vivo imaging technique (CellviZio developed by Mauna Kea Technologies of Paris), the UB researchers were ...JCI table of contents August 1, 2005
...r oral tolerance. These data provide the first in vivo evidence that epithelial cells can take up process... Thierry Martin and colleagues from INSERM show in vivo that an experimental infectious disease creates the necessary and sufficient conditions to activate ...How bacteria break B cell tolerance
... Thierry Martin and colleagues from INSERM show in vivo that an experimental infectious disease creates the necessary and sufficient conditions to activate self-reactive B cells with significant affinity. This could drive them to mature into harmful memory B cells and lead to autoimmune diseases in susce......findings that relieving this feedback mechanism in vivo greatly enhances tumor growth in this mouse model of tuberous sclerosis complex, raises some concern about the use of rapamycin to treat this disease. Pending the results of ongoing clinical trials with rapamycin, these studies suggest that combina......cs and colleagues from the NIH use cutting-edge in vivo labeling techniques to show that intermittent administration of IL-2 to HIV-infected patients induces a high level of proliferation of both CD4 and CD8 cells, followed by a remarkably prolonged survival of only the CD4 cells. These results help expl...Regulating cell shape in mycobacteria
... tuberculosis. The researchers identified three in vivo substrates of PknA and PknB, one of which (Wag31) is an important factor in controlling bacterial cell division and cell shape. Overexpression of either Pkn protein results in a cell shape defect. Dr. Husson is confident that "these findings describ...42 biomedical scientists worldwide named HHMI international research scholars
...the hypothesis using biochemical, cellular, and in vivo model systems. The finding may permit development of novel and effective infection control strategies. Isabel Roditi, D.Habil, Ph.D. Director University of Bern Bern, Switzerland Isabel Roditi wants to learn...JCI table of contents July 1, 2005
...eptors alpha and beta regulate renin expression in vivo AUTHOR CONTACT: Victor Dzau Duke University, Durham, NC USA Phone: 919-684-2255; Fax: 919-681-7020; E-mail: victor.dzau@duke.edu View the PDF of this article at: https://www.the-jci.org/article.php?id=24594 GENETICS Cause of deadly skin diseas...Viagra shows potential vasopressin-independent cGMP signaling in certain diabetes
...nsertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra)," is in the June issue of the American Journal of Physiology-Renal Physiology, published by the American Physiological Society. The research was conducted by Richard Bouley, Nuria Pa...Does gene therapy work? Nuclear medicine may provide the answers
...ver, no data have been available on using Cyr61 in vivo for fighting chronic myocardial ischemia (insufficient blood flow and oxygen to the heart muscle). "Cyr61 gene transfer appears potent in stimulation of myocardial angiogenesis--a novel gene therapeutic approach that seeks to induce the growth of new...Most common lung cancers may begin in newly discovered cells
...BASCs and put them back into the mouse and show in vivo that they perform as stem cells," Bender Kim said. "We don't have an assay for that yet." With hematopoietic stem cells, for example, scientists can inject the stem cells into the bone marrow of an irradiated mouse and replace the entire blood syste...'Jumping genes' contribute to the uniqueness of individual brains
...N. Marchetto, "because then we knew it happened in vivo and couldn't be dismissed as a tissue culture artifact." Transposable L1 elements, or "jumping genes" as they are often called, make up 17 percent of our genomic DNA but very little is known about them. Almost all of them are marooned at a permanent ...Burnham Institute awarded $13 M for Program of Excellence in Nanotechnology
...r President/CEO of The Burnham Institute, using in vivo phage display technology discovered in his laboratory, will identify and develop targeting elements needed to target the delivery of nanodevices to vulnerable plaque. Dr. Ruoslahti is credited with the first successful targeted delivery of a nanomac...Monkeying around to improve organ transplantation
...r the first time that anergic T cells generated ex vivo suppress renal allograft rejection in non-human primates. This may be an approach that could be used in human transplant trials....JCI table of contents July 1, 2005
...r the first time that anergic T cells generated ex vivo suppress renal allograft rejection in non-human primates. This may be an approach that could be used in human transplant trials. Title: Renal allograft rejection is prevented by adoptive transfer of anergic T cells in non-human primates AUTHOR CONT...Results of world's first gene therapy trial for arthritis show approach safe, feasible
...th an otherwise healthy patient population, the ex vivo protocol was the most appropriate approach to take...rse events in their nine patients. Although the ex vivo approach did prove safe and was able to confer gene expression within arthritic joints, the authors ......e whether PIs can inhibit programmed cell death in vivo and the mechanisms involved. The authors show tha... data show that PIs block programmed cell death in vivo and that related compounds may be useful for non-HIV disorders also characterized by excessive progr...