Fatty acid catabolism higher due to polyphenol intake
...effects in humans. De Boers research shows that in vivo research with polyphenol metabolites is necessary to study the effects of polyphenols. Rubicon Vincent de Boer recently received a Rubicon fellowship from NWO for his new research into the role of mitochondrial SIRT1 analogues in aging and energ...NYU's Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
...ional predictions, the NYU team developed a new in vivo analysis system comparing the expression of a reporter, green fluorescent protein (GFP) carrying target 3 UTRs with controls that did not carry the target 3UTRs. The laboratory results confirmed the role of specific 3 UTRs in suppressing gene express...DNA-damage test could aid drug development
...esses, in vitro human models could be closer to in vivo human than in vivo mouse," notes Shuga. "That premise will be tested in coming years as new systems become available." ...Insulin therapy shown to treat early experimental diabetic retinopathy
...acodynamic properties were studied in vitro and in vivo using R28 cells in culture and SD rats respectively. Lead researcher Ravi S.J. Singh, MD, of the Pennsylvania State College of Medicine in Hershey, Penn., reports that low dose periocular delivery of insulin to the retina of diabetic rats does not...LIAI scientists make important finding on cytomegalovirus transmission
... and two ways in which we can modulate immunity in vivo with the desired result of blocking virus spread to uninfected individuals. "The potential excitement in the findings is that we may be able to one day use this kind of treatment in humans to block or significantly reduce the spread of cytomegalovi...NIH awards VBI, Mayo Clinic $2.4M to study chronic rhinosinusitis
...ic genes that will be evaluated in in vitro and in vivo immunological assays during the course of the project. Dr. Kita commented: "Certain molds in the environment, especially Alternaria, are also risk factors for bronchial asthma and CRS. When extracts of Alternaria were tested in the laboratory with ...Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
...aptive feature in most circumstances. SCN cells in vivo must synchronize not only to light-dark cycles but also to one another to coordinate circadian behavior. Lack of coupling may allow peripheral oscillators to anticipate and respond rapidly not only to the synchronizing cues emanating from the SCN but...Tips from the Journals of the American Society for Microbiology
...be useful in comparative studies of TSE strains in vivo as well as for testing potential anti-TSE therapeutic agents. (G.J. Raymond, L.D. Raymond, K.D. Meade-White, A.G. Hughson, C. Favara, D. Gardner, E.S. Williams, M.W. Miller, R.E. Race, B. Caughey. 2007. Transmission and adaptation of chronic wast...Study shows hibernating bears conserve more muscle strength than humans on bed rest do
...eletal muscle strength, fatigue resistance, and in vivo contractile properties of intact muscles in bears within their natural dens." Adapting a system used for the evaluation of neuromuscular disease progression in humans, the researchers tested black bears from Middle Park, Colorado, both early and la...Oncolytics Biotech Inc., research collaborators demonstrate reovirus/gemcitabine
...N and gemcitabine resulted in both in vitro and in vivo synergy. There was no toxicity associated with the combined treatment. Tumours treated with the combination were significantly smaller (by area and weight) than tumours in control groups or tumours treated with either agent alone. The researchers ...Bioluminescence at the service of a novel cerebral imaging technique
...boration have developed a new technique for the in vivo imaging of neuronal function using bioluminescence, based on a GFP-aequorin fusion protein. This imaging technique enables the monitoring of neuronal activity (and more specifically, calcium activity), real-time and in-vivo, in either a small group o...Enhancing chemotherapy's efficacy: New agent has synergistic effect with standard drugs
...110, has a synergistic effect both in vitro and in vivo when used with current chemotherapy drugs such as ...al Molecular Cancer Therapeutics ("In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathwayand microtubule-targeting inhi...Study shows isolation of stem cells may lead to a treatment for hearing loss
... loss. This line of research will evaluate the in vivo survival and differentiation of self-renewing cochlear cell populations and potentially lead to new therapies for the numerous individuals that are going to suffer from noise-induced hearing loss in the near future....UT Metroplex institutions to collaborate on biomedical research
...nanocomposite materials. "Quantification of in vivo protein dynamics at the single molecule level" Dr...lation for biofilm removal on cochlear implant: in vivo and in vitro studies" Dr. Hoi Lee, assistant professor of electrical engineering at UT Dallas, and ...Research on microfluidics widens the possibilities for electronic devices
...ass, meaning in a test tube or other vessel) or in vivo (meaning in the body). Researchers are constantly striving for ways to optimize drug delivery to the patient. Devices perform many functions in drug delivery to measure the existing condition and to measure the effect of the medicine, for example. Th...JCI table of contents: April 2, 2007
...portantly, neutralizing either IFN-gamma or IDO in vivo caused heart graft rejection in rats treated with ...actor2 (HIF-2) regulates hepatic erythropoietin in vivo AUTHOR CONTACT: Volker H. Haase University of Pennsylvania School of Medicine, Philadelphia, Pennsy...Widely used iron nanoparticles exhibit toxic effects on neuronal cells
...tic force. Eventually they had hoped to conduct in vivo experiments, using nanoparticles-laden nerve cells to bridge regions of damaged neurons. However, when they added nerve growth factor to nanoparticle-laden cells in culture flasks, they observed toxic dose-dependent effects: some cells died, and many...Light-activated therapy targets DNA components
...r, Synthesis, characterization, DNA binding and in vivo activity of Ru(II)/Pt(II) complexes (INOR 690), will be presented at 1:50 p.m. Tuesday, March 27, at McCormick Place Lakeside room E253D by Jain. Co-authors are Brenda S. J. Winkel, professor of Biological Sciences at Virginia Tech, and Brewer. Ja...JCI table of contents -- March 22, 2007
...ins role in blood clotting differs in vitro and in vivo The formation of a blood clot (also known as ...on, have now shown that vWF is not required for in vivo platelet activation in mice in which tissue injury was induced with a laser. In the study, which ...Small molecule derived from Rb2/p130 could act as cancer therapeutic
...emonstrated the ability to inhibit tumor growth in vivo and could be developed into an anti-cancer therapeutic, according to researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine. The researchers reported their findings, "A small molecule based on the pRb2/p130 sp...