Chemical cues turn embryonic stem cells into cerebellar neurons
...ing how embryonic stem cells could be regulated in vivo and ultimately used for cell replacement therapy, especially after childhood tumors, in the central nervous system. Hatten and postdoc Enrique Salero found that in order to get the embryonic stem cells to differentiate, progressing through each of ...JCI table of contents -- March 8, 2006
...ptide derepresses p73 to cause tumor regression in vivo AUTHOR CONTACT: Kevin M. Ryan Beatson Institute ...tion, Jeffrey Whitsett and colleagues show that in vivo expression of SPDEF in mouse lung epithelial cells is increased by IL-13 (a soluble factor associate...News tips from the Journal of Neuroscience
...ectum. However, time-lapse confocal microscopy in vivo revealed abnormal features in RGCs, including axons with immature growth cone-like morphology, reduced branching, increased motility, and less presynaptic specializations. Consistent with a cell-autonomous presynaptic site of action, these changes w...Researchers at IRB Barcelona discover a new mechanism that regulates stem cell division
...olution microscopy techniques, thereby allowing in vivo observations. Elena Rebollo, member of the research team and first author of the study, explains that "thanks to these techniques and to hundreds of hours of filming, we have been able to observe the step-by-step process of stem cell division. We...Researchers wake up viruses inside tumors to image and then destroy cancers
... The technique is the first in the new field of in vivo molecular-genetic imaging that doesn't require transfecting tumors with a "reporter" gene, the scientists say. "The beauty of this is that you don't have to introduce any reporter genes into the tumor because they are already there," says radiologi...Ingredient in Big Macs and sodas can stabilize
... biocompatible properties, they can be used for in vivo (inside the body) molecular imaging and therapeuti...r therapy. Gold nanoparticles could function as in vivo sensors, photoactive agents for optical imaging, drug carriers, contrast enhancers in computer tomog...New imaging technique tracks traffic patterns of white blood cells
...r intravital observations of leukocyte behavior in vivo by allowing the near-simultaneous observation of c...es will greatly aid investigations to elucidate in vivo imflammatory cell behavior, and provide a powerful tool for the development of therapeutics for thes...Xie Lab demonstrates the role of microRNA pathway
...entially be used to control stem cell functions in vivo and stem cell expansion in vitro." "We are in the process of identifying the microRNAs that are important for stem cell self-renewal," said Dr. Xie. "Understanding the mechanisms controlling stem cell self-renewal will be crucial to our developing ...New hope for regenerative medicine
... had some capacity to form tissues in vitro and in vivo but it was questionable if these embryonic stem cells could generate transplantable material that would proliferate and replace tissues in an adult." The researchers took a two-step approach: First they injected uniparental ES cells into wild-type...ACS News Service weekly PressPac -- Feb. 7, 2007
... cancer, but this bioactivity must be confirmed in vivo in the future," they conclude. ARTICLE #3 FOR IMMEDIATE RELEASE "In Vitro Activity of Olive Oil Polyphenolic against Helicobacter pylori" DOWNLOAD PDF http://pubs.acs.org/cgi-bin/sample.cgi/jafcau/2007/55/i03/pdf/jf0630217.pdf DOWNLOAD HTML http...Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
...ed no correlation between cellular activity and in vivo efficacy," Janda said, "which is highly unusual. Clearly, cell-based assays do not provide all the necessary informationanimal-based studies are still an essential part of the discovery process. These findings validate our multidisciplinary screening...News tips from the Journal of Neuroscience
...ype II and III boutons. GTX and DLG interacted in vivo , and targeting of GTX to the SSR depended on DLG. Like dlg mutants, gtx mutants exhibited a severely compromised SSR. Overexpression of GTX resulted in the formation of extrasynaptic SSR-like structures independent of DLG, indicating a role for ...Advances in Optics for Biotechnology, Medicine and Surgery
...medical applications of optics, with a focus on in vivo and molecular imaging, and to encourage participation by clinicians. The conference will be a continuation of meetings on this topic sponsored by Engineering Conferences International. This is the tenth conference in this series. In each of the s...News tips from the Journal of Neuroscience
...leus of the thalamus (VM) in anesthetized rats in vivo and found that the cells displayed high frequency burst firing during SWDs. Next, the authors locally injected a glutamate receptor antagonist to block neuro-transmission in the substantia nigra pars reticulata, a basal ganglia output structure that...ACS News Service Weekly PressPac -- Jan. 17, 2007
...s or via computer simulation and has joined the in vivo and in vitro experiments traditionally used in the life sciences. The researchers screened a database of chemical structures of Chinese herbal constituents from 240 species of plants for possible activity against various diseases. About 62 percent o...News tips from the Journal of Neuroscience
...velop strategies for measuring gene expression in vivo , Liu et al. coupled oligonucleotides to superpara... c-fos mRNA was retained in some brain regions in vivo consistent with binding to c-fos mRNA as confirmed by detection of intracellular iron oxide by Prus...News tips from the Journal of Neuroscience
... pattern that fitted GnRH-1 neuronal migration in vivo . Tissue-type plasminogen activator (tPA), which cleaves and activates pro-HGF, was also expressed by migrating GnRH-1 neurons. In explants treated with an HGF-neutralizing antibody, the number of GnRH-1 neurons was unaffected, but migration was cons...Getting to the bottom of memory
... Sevilla, Spain, who performed the behavior and in vivo recordings. "To assess if the molecular mechanisms that generate LTP also underpin memory formation you need to study a living animal while it is learning." Minichiello and her team combined molecular, electrophysiological and behavioural methods in ...News tips from the Journal of Neuroscience
...SI in slices from animals that had experienced in vivo hypothermia-induced febrile seizures, in which DSI was already elevated. In vivo , a CB1 antagonist blocked the seizure-induced DSI potentiation, the associated upregulation of CB1 ...Two studies: Speeding development of novel tracer for prostate cancer
...stance) from in vitro stage (in a test tube) to in vivo (within a live subject) in animals to in vivo in individuals with prostate cancer, explained Schuster. The Emory pilot study with FACBC, performed...