ACS News Service Weekly PressPac -- Dec. 20, 2006
...ples. In other situations, the goal is to study in vivo the temporal and spatial distribution of bacteria in live animals." ARTICLE # 2 FOR IMMEDIATE RELEASE "Optical Imaging of Bacterial Infection in Living Mice Using a Fluorescent Near-Infrared Molecular Probe" DOWNLOAD PDF http://pubs.acs.org/cgi-bin...News tips from the Journal of Neuroscience
...activity such as deep anesthesia in rat brains in vivo . The authors also tested glutamate excitation of cultured neurons. In each case, S603 was much more sensitive. Increased neuronal activity led to calcineurin-mediated dephosphorylation, whereas reduced activity increased phosphorylation, providing a...Study identifies glucose 'sensor' that plays dual role in glucose metabolism and fat synthesis
...dicating that LXR functions as a glucose sensor in vivo that responds to increasing liver glucose uptake. The ability of the LXRs to respond to glucose and its derivatives was very specific: no effect was seen in other nuclear receptors tested. The current study focused primarily on the role of glucose s...Dengue and other hemorrhagic fevers: Towards a first potential treatment
...ific metalloproteinase inhibitors. A series of in vivo experiments following the same principle confirmed these hypotheses. A mouse model with blood circulatory system coloured blue was injected with supernatant containing these enzymes, on their own or in the presence of their inhibitor. This procedure ...JCI table of contents: Dec. 21, 2006
... human bone cells in vitro and mouse bone cells in vivo but does not cause a Padget-like disease in mice. Specifically, expression of p62P392L in the precursors of human bone cells known as osteoclasts (the cells that destroy bone) caused them to be more responsive to factors that drive osteoclast develop...Researchers find biological clock for smell in mice
...ession of that gene. All of the data came from in vivo measurements." They saw more of those cells light up in the olfactory bulb at night than in the day. "The olfactory bulb might be more sensitive at night when the creatures are active than when they are resting in the day," Herzog speculated. "This...JCI table of contents: December 14, 2006
... opposing effects and which effect predominates in vivo have not been clearly established. Using mice, res... effects of IFN-gamma were found to predominate in vivo in 3 distinct models of bone loss (osteoporosis). It is therefore possible that targeting IFN-gamma ...Phylonix awarded National Science Foundation Phase II SBIR for zebrafish screening
...n 70% of these chemicals. The lack of efficient in vivo screening assays contributes to the lack of knowle...ies. However, a systematic analysis of effects in vivo in this model organism has not been performed....Varying weight training intensity increases growth hormone in women
...ce training in women potentiates growth hormone in vivo bioactivity: characterization of molecular mass variants," was carried out by Kraemer, Jeff S. Volek, Barry A. Spiering and Carl M. Maresh of the University of Connecticut, Storrs; Bradley C. Nindl, U.S Army Research Institute of Environmental Medici...Human testis harbors HIV-1 in resident immune cells
... which retained the same tissue architecture as in vivo tissue and continued to secrete testosterone, was able to support infection by HIV-1. Virus produced from the testis culture was fully active as collected virus was able to infect permissive cells in culture. The finding that HIV-1 can replicate w...Blame myelin for many neuropsychiatric disorders
...is, his hypotheses can easily be tested through in vivo imaging of the brain to study the breakdown and growth of myelin. That will make it possible to directly test in humans the practical utility of the myelin-centered model of the human brain. Ultimately, it could foster the development of novel trea...JCI table of contents: November 9, 2006
...oduced substantially less IL-10 when stimulated ex vivo with antibodies specific for CD3 and CD46 than T cells from healthy individuals. This inability to induce a Tr1 cell phenotype was associated with altered expression of CD46 cytoplasmic isoforms upon activation. This study shows that a second regulat...SNM: Exploring molecular imaging potential
... biology will lead to a package of noninvasive, in vivo imaging tools that could have vast potential for improving both patient care and the utilization of health care resources," he said. "Molecular imaging will complement the diagnosis and staging of disease in the absence of anatomic findings, help det...Scientists identify synthetic compound that keeps stem cells young
...stem cell fate and ultimately may be useful for in vivo stem cell biology and therapy studies," says Ding....Turmeric prevents experimental rheumatoid arthritis, bone loss, University of Arizona study shows
...arthritis. This study also provides the first in vivo documentation of a mechanism of action how curcumin-containing extracts protect against arthritis. The researchers found that the curcuminoid extract inhibits a transcription factor called NF-KB from being activated in the joint. A transcription fac...News tips from the Journal of Neuroscience
...treatment of the cultures with exogenous BDNF. In vivo , the dendritic abnormalities were less dramatic, but still apparent. 2. Determining Sites of Synapse Formation Shasta L. Sabo, Raquel A. Gomes, and A. Kimberley McAllister What determines where synapses will form along an axon? Sabo et al. try ...New biologic treatment for tennis elbow may replace surgery for chronic sufferers
... Center, Menlo Park, Calif. "Ours is the first in vivo human investigation of this novel biologic treatment for chronic severe elbow tendonitis in patients who have simply 'flunked out' of other treatments," says Dr. Mishra. "Ninety-three percent of patients in our study did well, which is as good a res...HYPER-CEST MRI breaks new ground in molecular imaging
...t HYPER-CEST is in the sensitivity ballpark for in vivo molecular imaging. In vivo molecular imaging is a very important tool if the dream of personalized medicine, where treatments a...Tips from the journals of the American Society for Microbiology
...ation of a fully human MAb with potent activity in vivo and uncovered a previously unrecognized mechanism of antibody-mediated toxin neutralization that is important for currently used anthrax vaccines," say the researchers. (L. Vitale, D. Blanset, I. Lowy, T. O'Neill, J. Goldstein, S.F. Little, G.P. An...Forsyth scientists find linkages between serotonin reuptake inhibitors and bone mass
... The study concluded that fluoxetine treatment in vivo leads to increased bone mass under normal physiological conditions or inflammatory conditions, but does not prevent bone loss associated with estrogen deficiency. This research, which will be published in the next issue of the Journal of Cellular B...