Pinning down a cancer threesome
...eveloped extensive skin tumors. "This work is in vivo proof-of-concept of a key pathway in epithelial tumors," remarks Trumpp. "The gene that is truly critical and protects the cells from oncogenic activity is p21. Inhibiting the c-myc pathway was always thought to be unreasonable because this gene is t...News tips from the Journal of Neuroscience
...so produce limited numbers of oligodendrocytes in vivo . The authors used several approaches to identify cells. For example, using electron microscropy, the authors characterized the subset of cells in the SVZ that expressed Olig2, a transcription factor and marker of OPCs. About one-half looked like tra...Possible birthplace of malignant brain tumors identified
...o brain tumors. "However, it has not been shown in vivo that tumor stem cells are derived from normal stem cells or that a specific population of cells with demonstrated stem cell properties is capable of initiating tumor formation," wrote the researchers. Using tracers, the researchers discovered that ...Researchers unveil strategy for creating actively-programmed anti-cancer molecules
...ve assembly of chemically programmed antibodies in vivo or in vitro, widening the possibilities for their therapeutic application. The compound could be created in vitro and delivered as a conventional single therapy. Alternately, the small molecule and antibody could be injected separately, with the new ...News tips from the Journal of Neuroscience
...ssing a large sample of rat lumbar DRG neurons in vivo . The authors typed the DRGs in terms of size and ...ecursor neurons of the upper rhombic lip. With in vivo timelapse confocal microscopy, the authors watched these cells migrate toward the MHB, turn ventral...Celiac success: New enzyme efficiently degrades gluten in 'human stomach' environment
...re are no animal models of celiac disease, "the in vivo efficacy of AN-PEP for gluten detoxification will ultimately have to be addressed in clinical studies involving celiac patients. AN-PEP appears to be a prime candidate for such clinical trials," the paper concluded. As for the timing of any such tria...NYU scientists begin second phase of project to better understand disease
...understand how proteins perform their functions in vivo (in the cell) and the roles of proteins in diseases. With a greater understanding of protein structure, scientists can learn more about the biological systems that underlie most human activity (biomedical, agricultural, environments). In the end, thi...JCI table of contents: June 22, 2006
...strategy for cancer vaccine development. TITLE: In vivo antigen delivery by a Salmonella typhimurium type ...versity of Virginia describe the creation of an in vivo mouse model of KSHV infection. The authors intravenously injected non-obese diabetic/severe combined...How IVF could be causing genetic errors in embryos
...pression after in vitro culture compared to the in vivo embryos. Five genes showed a statistical difference compared to the in vivo control, depending on the culture conditions," he said. The five genes were: Cd81 expresses a memb...News tips from The Journal of Neuroscience
...eonatal shiverer mouse brains differentiated in vivo and formed compact myelin....Next generation of science stars: 5 female scientists receive 2006 LOral USA fellowships
...cture and biochemistry. She is deciphering the in vivo functions of the protein spastin, which is affected in the hereditary disease, Hereditary spastic paraplegia (HSP). Dr. Roll-Mecak's research project aims to improve the understanding of the mechanism of action of spastin and the cellular consequenc...Brain's receptors sensitive to pot may 'open door' in treating drug dependence, brain disorders
...juana smoking," said Horti. The usefulness of in vivo (in the body) radioligands for studying cerebral receptors by PET depends on the image quality, and a good PET radiotracer must display a high level of specific receptor binding and low non-specific binding (binding with other proteins, cell membrane...Innovations needed to monitor kidney health
... of the kidney. These include a novel method of in vivo biotinylation and state of the art proteomics on kidney samples during the development of experimental diabetic nephropathy, Dr. Holthfer tells....News tips from The Journal of Neuroscience
...pioid neurotransmission as measured by reduced in vivo receptor availability. In a test of recall, estrogen-treated subjects also underestimated the pain. 4. Strain-Dependent Regeneration without Nogo-A Leda Dimou, Lisa Schnell, Laura Montani, Carri Duncan, Marjo Simonen, Regula Schneider, Thomas Lieb...JCI table of contents, May 18, 2006
...ty of California, San Francisco, describe a new in vivo mouse model of TRALI and provide novel insights in...sistance to lung injury. In conclusion, the new in vivo mouse model of TRALI reproduces several features of human TRALI, and the results of these studies su...News tips from The Journal of Neuroscience
...thasone (Dex) also decreased NSC proliferation in vivo . A 3 d treatment of embryonic day 14 pregnant rats reduced NSCs in the pups by one-third, an effect attributed to decreased proliferation rather than increased cell death. The authors estimated that the treatment half-saturated glucocorticoid recept...Gains in the fight against acid aspiration lung injury
...acid aspiration lung injury accurately imitates in vivo cell death and shedding as well as recovery, thus providing researchers a means of testing new treatment strategies for hastening resolution of acid-induced damage....Protective action of a molecule in inflammatory processes discovered
...f the methylthioadenosine (MTA) molecule in an in vivo inflammation model. The doctor has recently defen... damage. These studies were undertaken in both in vivo and in vitro models and, in all of these, the potent anti-inflammatory effect of MTA could be ver...APS research awards go to undergrads at Colorado State, Michigan State, Oberlin, Williams
...c reticulum stress increases glucose production in vivo via effects on live glycogenolysis and glucose-6-phosphatase activity," by Jon C. Gonzales, Yuren Wei, Dong Wang and Michael Pagliassotti, Colorado State. Gonzales, who plans to graduate in May 2007, hopes to enroll in a Ph.D. program in biomedical s......e activity of WRN-exo, we did both in vitro and in vivo assays," Yannone says. "In the test tube, manganes... the relation of structure and function in WRN. In vivo assays were performed with cell lines, including Werner's syndrome cells, supplied by Berkeley Lab's...