Contagious obesity? Identifying the human adenoviruses that may make us fat
...ogenic potential of multiple human adenoviruses in vivo and in vitro in animals," in the January issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology published by the American Physiological Society. The study, by Whigham, Barbara A. Israel and Richard L. Atkinson...Discoveries may advance stem cell therapy for Parkinson's, cancer patients
...critical intrinsic dopamine-neuron determinants in vivo and suggest that they may be essential tools in cell replacement strategies in Parkinson's disease." Further study will elucidate the utility of the stem cell-derived neurons for treating rats with Parkinson's disease, they said. The researchers will...Swiss researchers develop all-in-one remote control gene expression tool
... injected into living cells either in vitro or in vivo the genetic material aboard the lentiviral vector...gene function in tumor cells and for generating in vivo tumor models for drug screening and delivery. In another application, dying cells (such as neurons)...Mouse model reveals that oncoprotein induces abnormal preleukemic blood cell progenitors
... target genes in blood cell progenitors and the in vivo validation of cooperating oncogenes, as well as for the evaluation of candidate drugs for improved treatment of AML."...WT1, male fertility and tumorigenesis
.... In a powerful example of the utility of their in vivo RNAi technology, the authors knock-down expression of WT1 specifically in Sertoli nurse cells in vivo. In conjunction with similar results the researchers obtained from dominant negative WT1 experiments, the authors conclude that the WT1 tumor suppre...JCI table of contents: January 4, 2006
...romatin regulates smooth muscle gene expression in vivo AUTHOR CONTACT: Gary K. Owens University of Virginia Health Sciences Center, Charlottesville, Virginia, USA. Phone: 434-924-5993 Fax: 434-982-0055 E-mail: gko@virgina.edu . View the PDF of this article at: https://www.the-jci.org/article.php?id=...JCI table of contents: December 22, 2005
...s IL-13induced lung inflammation and remodeling in vivo AUTHOR CONTACT: Jack A. Elias Yale University School of Medicine, New Haven, Connecticut, USA Phone: 203-785-4163; Fax: 203-785-3826; E-mail: jack.elias@yale.edu View the PDF of this article at: https://www.the-jci.org/article.php?id=25711 IMMUN...New procedure reveals the secrets of the brain
...ng the utility of their technique in uncovering in vivo functional connectivity maps. Using the microstimulation/MRI technique in conscious, alert primates holds great promise for determining the causal relationships between activation patterns across distributed neuronal circuits and specific behaviors. ...Brain activity, drugs could affect Alzheimer's progression
...aptic activity and A levels are directly linked in vivo may have important treatment implications," they wrote. "Drugs used to treat neuropsychiatric disorders, such as depression or anxiety, among many others, directly influence neurotransmitters, and their receptors, thereby altering synaptic activity,"...LIAI initiatives battle influenza; Potential bird flu treatment among their findings
...utre said. "This reactivity means that if used in vivo (in a living organism) the infected cells would be recognized by the antibody and destroyed by the immune system." The study also found that a relatively low dose of the antibodies was needed to fight the various flu strains. While most of the wo...A crucial role for TGFbeta signaling in congenital eye disorders
... international team including Lars Ittner, used in vivo cell fate mapping in mice. They show that NC-derived cells can be found in the eye vesicle of mouse embryos, soon after it is formed. NC-derived cells subsequently contribute to various structures of the developing eye, and Ittner et al. show for the...A Jekyll-and-Hyde enzyme's role in Alzheimer's
...together these data suggest that p25 production in vivo is not detrimental per se but can lead to neuronal cell death when p25 levels are chronically high," concluded Tsai and colleagues. "In summary, it is intriguing that several studies suggest that during the pathogenesis of AD, which manifests over se...Study in Royal Society journal on link between creativity and mating success
...is a powerful non-invasive technique to measure in vivo blood flow. Its sensitivity is usually restricted to prevent the measured phase from being 'wrapped' onto the range л to +л. Otherwise, the true phase must be estimated from the measured wrapped phase by a non-trivial phase unwrapping pro...Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
...oshells for Combined Cancer Therapy and Imaging in vivo (Abstract 2711) Researchers at Rice University are working on a novel and systematic approach to cancer treatment that involves the use of advanced technologies that are by themselves harmless − but appear to offer potent cancer-killing prope...Tips from the journals of the American Society for Microbiology
...e attenuates Sindbis virus infection, providing in vivo evidence that ISG15 can function as an antiviral molecule," say the researchers. (D.J. Lenschow, N.V. Giannakopoulos, L.J. Gunn, C. Johnston, A.K. O'Guin, R.E. Schmidt, B. Levine, H.W. Virgin IV. 2005. Identification of interferon-stimulated gene 1...Innovative research set to push boundaries of cancer care
...aditional chemo-radiation treatment, he adds. In vivo Evaluation of Radioprotection by the Fullerene CD60_DF1 Using a Zebrafish Model (Abstract 3381) As beneficial as chemotherapy and radiotherapy are in managing cancer, these treatments can cause harm to normal tissue by producing stress on cells. One...Compound in wine reduces levels of Alzheimer's disease-causing peptides
... to find more stable analogues and to test them in vivo in mice." Additional good news is that resveratrol may also be effective in fighting other human amyloid-related diseases such as Huntington's, Parkinson's and prion diseases. Studies by a group at the Institut National de la Sant et de la Recherche ...Gene therapy improves gemcitabine effects in experimental glioma model
...nsitising effect. Unsurprisingly, results from in vivo mouse studies mirrored the murine cellular assay findings. Although the combination of gemcitabine and radiotherapy had a pronounced synergistic effect, with 60% of animals tumour-free after 100 days compared to 0% on monotherapy, increased dCK level...Wnt signaling controls the fate of stem cells in adult brains
...d to us that the Wnt signal is really important in vivo and not just a tissue culture artifact." Many inv...is occurs, we have a tool to block neurogenesis in vivo and find out what its function is," he adds.......er membrane. Furthermore the apoptosis detected in vivo in patients who died from necrotizing pneumonia suggests that apoptosis could be directly involved in the pathology of necrotizing pneumonia. This is important since S. aureus necrotizing pneumonia is rapidly and highly lethal in young immunocompete...