Delving deeper into the machinery of cocaine addiction
...dy such transcriptional mechanisms in the brain in vivo and understand, with increasing complexity, how chronic cocaine administration leads to the long-term regulation of its target genes." The researchers found that giving the rats acute doses of cocaine induced histone modifications that activated a ge...Improved blood safety measures from Pall can increase platelet availability
...ate the value of prestoraged pooled platelets. In vivo studies showed that prestoraged pooled platelets have an equivalent clinical response (the number of platelets that continue to circulate in the human body post-transfusion) to platelets pooled at the time of transfusion. The pooled and stored plate...Studies validating performance of Pall prion reduction technology presented at AABB
...ted showed mean values of 85.0 and 82.9 percent in vivo red cell recovery, exceeding the FDA required mean...mum limit. The researchers concluded that both in vivo and in vitro results of this study indicate that leukoreduced red cell products filtered through the...Neural stem cells are long-lived
...hers also found evidence that neural stem cells in vivo responded to Shh signals by giving rise to other neural cell types, including glial cells that support and guide neurons. "An important point is that earlier studies indicating that neural stem cells could give rise to multiple cell types had been do...JCI table of contents October 3, 2005
...tor of macrophage reverse cholesterol transport in vivo AUTHOR CONTACT: Daniel J. Rader University of Pennsylvania Medical Center, Philadelphia, PA USA Phone: 215-573-4176; Fax: 215-573-8606; E-mail: rader@mail.med.upenn.edu View the PDF of this article at: https://www.the-jci.org/article.php?id=...Burnham Institute to collaborate in NCI funded Center of Cancer Nanotechnology Excellence
...livery of a nanomachine into live tissue. Using in vivo phage display technology discovered in his laboratory, Ruoslahti has identified and developed targeting elements needed to hone in on the delivery of nanodevices to vulnerable plaque. The Institute was recently selected as a "Program of Excellence in...Different but equal: Settling the dosage compensation debate
.... These two papers provide the first definitive in vivo evidence in favor of the activation model of dosage compensation in flies. The male-specific-lethal (MSL) complex functions as a male-specific regulatory protein complex that controls gene expression in male fruit fly cells. The activation model prop...Engineered molecule amplifies body's immune response
...stablish the benefits of hyper-responsive Stat1 in vivo for treating viral infection and cancer. They are also screening for drugs that might increase Stat1 responsiveness. These experiments may eventually lead to many improvements in cancer therapy as well as the treatment of other infections. Basically,...JCI table of contents October 1, 2005
...erine Postic and colleagues from INSERM provide in vivo and in vitro evidence for a novel regulatory mechanism of the transcription factor ChREBP (carbohydrate-responsive element-binding protein) activity by PUFA in the liver and demonstrate the direct role of ChREBP in mediating the negative effect of PU...News tips from the Journal of Neuroscience
...use model ofAlzheimer's disease in vitro and in vivo .Epigallocatechin-3-gallate (EGCG), themain polyphenolic component of green tea,reduced -amyloid (A) production inneurons cultured from APP-overexpressingmice (Tg APP SW ). After 2 months of treatment,A-containing plaques were significantlyreduced....Cytokinetics presents data on CK-1827452
...Chief Executive Officer. "Today's data provide in vivo validation which led to the advancement of CK-1827452. The recent initiation of a Phase I clinical trial for this drug candidate is an important step forward for Cytokinetics and this program." Development Status of CK-1827452 CK-1827452, a novel...Old drug shows new promise for Huntington's Disease
...," Massa concluded. "Together, the in vitro and in vivo results suggest that Clioquinol has an effect of decreasing the symptoms of Huntington's, its pathology, and perhaps even the actual production of the toxic protein." However, he noted, "the drug's mechanism of action remains unclear." The clearer th...JCI table of contents September 1, 2005
...nscription programs activated by angiotensin II in vivo and determination of the hierarchy of responses are vital to the understanding of the mechanism of vascular disease and to the development of therapies targeted at inhibiting the common transcription effectors of vascular physiology." TITLE : Ets-1 ...New dye could offer early test for Alzheimer's
...ustments in these dyes will allow us to perform in vivo analysis through human tissue." The new dye was developed as part of a broader effort in sensing technology at MIT's Institute for Soldier Nanotechnologies. In addition to its applications as a medical diagnostic, Swager says fluorescing dyes like N...VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease
...ceived IFNγ. Similar results were reported in vivo using a mouse model. Mice with a mutation that causes them to overproduce IFNγ were used, and again, researchers observed a significant decrease in mast cell numbers due to the excess of IFNγ. When researchers tried to culture mast cells fr...Looking at autoimmune diabetes, literally
...1 diabetes that can guide the application of an in vivo MRI technique to patients with autoimmune diabetes....JCI table of contents September 1, 2005
...1 diabetes that can guide the application of an in vivo MRI technique to patients with autoimmune diabetes. Title: Seeing autoimmunity - noninvasive imaging of type 1 diabetes and its reversal AUTHOR CONTACT: Diane Mathis Joslin Diabetes Center, Boston, MA USA Phone: 617-264-2701; Fax: 617-264-2744; ...... of RhoC-deficient mice, providing long-awaited in vivo confirmation of RhoC's critical role in tumor metastasis. They found that RhoC, a Ras-related GTPase, is dispensable for embryonic development and tumor initiation, but is essential for metastasis. RhoC-deficient mice do not display gross phenotypic...Stem cells bring fast direct improvement, without differentiation, in acute renal failure
...ed to prove that no adverse effects occur after in vivo administration of adult MSC. Also to be determined is whether renoprotective and gene-modulating effects of MSC "are primary actions that are humorally elicited by these cells or whether they result from the improvement of tissue injury by as yet u......ous cellular processes, but their precise roles in vivo were not clear because genetic loss of Foxo function had diverse effects. In a study appearing online on August 11 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Stefanie Dimmeler and colleagues fro...