Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
BOSTON -- Muscle wasting is associated with aging and a serious consequence...in the Oct. 15 issue of the journal Cell. Muscle wasting is a hallmark of a number of diseases, including cancer, bacterial sepsis, AIDS, diabetes, and end-s...JCI table of contents, November 15 2004
... Understanding the development of wasting in disused muscles For people with immobilized limbs, sedentary lifestyles or subject to extended periods of bed rest, muscle disuse often leads to the loss of muscle tissue known as muscle atrophy. Earlier studies have implicated ...Muscle loss from space travel, prolonged inactivity linked to two genes
... bcl3 , can block the biological process of muscle wasting known as atrophy. Their findings will inform efforts to identify therapeutics that could inhibit muscle atrophy caused by a chronic reduction in muscle use. Such treatments could end the muscle loss, weakness, and fatigue that can plague space tra...UCLA/VA researchers discover fat gene
...ate the lipin gene and link it to lipodystrophy, a wasting disorder in which the body is unable to produce fat. She also found that too little lipin prevented both genetic and diet-related obesity. For this study, Reue and coauthor Jack Phan, Ph.D., tested whether too much lipin would produce the opposite e......IGF-1 blocks angiotensin IIinduced skeletal muscle wasting AUTHOR CONTACT: Patrick Delafontaine Tulane University School of Medicine, New Orleans, Louisiana, USA. Phone: 504-587-2025; Fax: 504-587-4237; E-mail: pdelafon@tulane.edu . This article is available at http://www.jci.org/cgi/content/full/115/2/451...Fine-tuning calf nutrition could reduce nitrogen pollution
...o the growth rate of the calf is increased without wasting feed dollars and sans the extra nitrogen in the manure. The key may be balancing the proportions of the 21 amino acids that make up proteins. "In current accelerated calf growth programs, amounts of all 21 amino acids are increased," Lambert said. ...Pall prion removal technology presented to FDA blood products advisory committee
...spongiform encephalopathy (BSE) in cattle; chronic wasting disease (CWD) in deer, elk and moose; and scrapie in sheep. These diseases are believed to be caused by prions, which are misfolded, or "rogue", infectious proteins. "So much remains unknown about prion diseases even as new information comes to lig...'You can't buy conservation,' suggests survey of Africa's rain forest parks
...erformance monitoring and accountability, to avoid wasting money and encouraging corruption. "Monitoring programs should include not only the plants and animals, but also the impact of humans on the park and the attitudes of people toward the park. It is only through such monitoring programs that one can obj...Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
...son has difficulty standing or walking. The muscle wasting is associated with an increase in free radical production and protein breakdown. Using mice unable to put force on their hind legs, researchers tested two diets: 1% Bowman-Birk inhibitor concentrate (a protease inhibitor made from soybeans) and the s...Fibril shape is the basis of prion strains and cross-species prion infection
...ous tangles called amyloid fibrils and cause fatal wasting of brain tissue. The abnormally folded protein its..., which suffer from a prion disease called chronic wasting disease. Surewicz stresses, however, prion infection between species is still rare. "Fortunately, tr...Strongest proof yet found for prion hypothesis
...utzfeldt-Jakob Syndrome, scrapie, kuru and chronic wasting disease. This controversial "prion hypothesis" was proposed by Stanley Prusiner in 1982, and led to Prusiner receiving the Nobel Prize in Medicine in 1997. Until now, however, scientists have been unable to confirm its validity by causing a TSE in no...JCI table of contents June 1, 2005
...cle.php?id=25399 PHYSIOLOGY Chronic disease body wasting due to loss of appetite Cachexia, the loss of body weight and muscle mass, is common in patients with chronic illnesses and contributes to mortality in patients with chronic kidney disease. These patients develop uremia, abnormally high levels of w...$7.3 million NIH grant establishes Wellstone Muscular Dystrophy Research Center at the UI
... of genetic diseases that cause progressive muscle wasting and weakness in affected individuals. The various types of muscular dystrophy differ in severity, age of onset, specific muscles affected and the rate at which symptoms progress. More than one million Americans have muscular dystrophy or a related ne...No small feat: First ever gene therapy success for muscular dystrophy achieved
...ies characterized by progressive and severe muscle wasting and weakness first noticed soon after birth. No effective treatments exist and children usually die quite young. Despite gene therapy being among the most vigorously studied approaches for muscular dystrophy, it has been beset with uniquely difficult...New analytical tool helps detect cancer
...that promote electron transport and prevent energy wasting recombination. The complexes must also be interfaced with a conducting material in order to harvest the energy. The controlled growth offered by DMEG can help overcome these hurdles. Another possible application is for desalinization of seawater, usi...Yerkes to develop first transgenic nonhuman primate model for inherited neurodegenerative diseases
...nges including the death of neurons that lead to a wasting away of the brain," said Dr. Chan. "Because of their genetic and behavioral similarities with humans, transgenic nonhuman primate models will allow us to clarify the correlation between defects and neurological changes caused by neurodegenerative dis...U of MN researchers develop tests for devastating cattle disease
...he bacteria that causes Johne's disease, a chronic wasting disease found in cattle and other ruminant animals such as sheep, goats and deer. This research, scheduled to be published in the Aug. 30 issue of the Proceedings of the National Academy of Sciences, also provides the foundation for a better unders...A fatty acid found in milk may help control inflammatory diseases
...a price, Cook says, including inflammation, muscle wasting and loss of appetite. "Conventional wisdom dictates that you can increase growth by treating the animal with antibiotics to kill bacteria and avoid activating the immune defense system, but this raises long-term concerns about developing antibiotic r...UW study shows deer in CWD zone stick to home
...nd wildlife managers better understand how chronic wasting disease (CWD) spreads. "They are using small home ranges and not traveling long distances," says Nancy Mathews, a wildlife biologist at the University of Wisconsin-Madison's Gaylord Nelson Institute for Environmental Studies. "The only dispersers ar...Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy
...r delta-sarcoglycan gene defect have severe muscle wasting and weakness and significantly shortened lifespans due to cardiac and respiratory failure. After injecting a very high dose of AAV-8 carrying a normal copy of the delta-sarcoglycan gene intravenously into 10-day-old and adult LGMD hamsters, Dr. Xiao ...