Viral 'fitness' explains different resistance patterns to aids drugs
...es multiple mutations, each of which significantly weakens the ability of the virus to replicate. These PI-resistant viruses only emerge, therefore, when challenged with high concentrations of drug. Overall, study findings showed that NNRTI resistance was found less often than PI resistance among patients ......eficient bone repair. "Alcohol-induced bone loss weakens the bones and predisposes alcoholics to a greater frequency of fractures from falls," said Chakkalakal. "A delay in fracture healing is another problem alcoholics experience that is not necessarily connected with the bone loss. What is common to bo...Bacteria that cause tooth decay able to survive without important biochemical pathway
...ithout a steady infusion of proteins, the membrane weakens and the cell - in this case, a bacterium - becomes unable to protect itself from harsh environmental conditions. In the human mouth, its natural environment, it is typically S. mutans that goes on the attack. When sugary foods are eaten, the S. muta...Hepatitis C complicated by morphine withdrawal
... HIV, this study suggests that morphine withdrawal weakens host cell immunity and provides a favorable environment for HCV growth in the liver. The authors extended their study by examining the mechanism behind these observations. MW and PW inactivated the IFN-alpha promoter (the switch for making IFN-alp...Alcoholics have a greater chance of infection following cardiac surgery
...s been proven to harm the body. In particular, it weakens the immune system, which every operative patient needs in order to fight postoperative infections." Sander also noted that the hospital costs of alcohol-related complications can be considerable. "If we estimate a cost of $2,000 in U.S. dollars (USD...Loyola researchers discover congestive heart failure biological marker
...llion people in the U.S. have CHF, where the heart weakens and becomes unable to pump adequate amounts of blood. When blood returning from the body to the heart is not pumped fast enough, it starts to back up into the lungs. CHF symptoms include shortness of breath, swollen legs, swollen liver and fatigue, w...Researchers find genetic link to cerebral hemorrhage and porencephaly
...nternational team discovered a genetic defect that weakens blood vessels in the brain, making an infant much more vulnerable to hemorrhaging. The team was led by Dr. Douglas Gould a postdoctoral fellow at The Jackson Laboratory and Jackson Laboratory Staff Scientist and Howard Hughes Medical Institute Invest...Hypoxia can offset the potentially damaging effects of oxygen therapy
...eam led by Michail Sitkovsky show that oxygenation weakens a tissue-protecting mechanism triggered by hypoxia. Hypoxia triggers a signaling pathway mediated by an adenosine receptor (called A2AR) that arrests inflammation and tissue damage; the researchers show that this same hypoxia-driven pathway protect...Purdue researchers align nanotubes to improve artificial joints
...ction response from the body. Rejection eventually weakens the attachment of implants and causes them to become loose and painful, requiring replacement surgery. Aligning the nanotubes to further mimic natural bone also might provide more strength, Webster said. Researchers used two methods to align the tiny...