Abnormal fat metabolism underlies heart problems in diabetic patients
...ped defects in mitochondrial function which became worse when they were fasted a condition that, like diabetes, causes the heart to use lipids for fuel. A 16-hour fast caused significant problems with the mouse hearts' ability to pump blood, again implicating altered lipid metabolism, cardiolipin scarcity...Sugar and spice and everything nice: Health differences in newborn girls and boys
... liver transplantation shows that the outcomes are worse for children who receive organs from female donors...ential explanation for pediatric studies reporting worse outcome of recipients receiving livers from female donors."...Macho men are seen as bad choice for long-term love
...sed as significantly more dominant, less faithful, worse parents and as having personalities that were less warm, compared to their feminine counterparts, who had finer facial features with fuller lips, wide eyes and thinner, more curved eyebrows. The scientists say the research, partly supported by th...Defects in critical gene lead to accelerated lung tumor growth
...with lung cancers harboring LKB1 mutations do much worse than those with other types of cancers; however, we still do not know what this gene does, Sharpless said. This mouse model will enable us to determine how this gene is important for lung cancer and to develop therapies targeted in a way that can hel...New survey documents the headaches of computerized medicine
... place by 2010. Fears that the CPOE cure might be worse than the disease likely are impeding the diffusion of CPOE throughout hospitals in the United States, the authors of the JAMIA paper asserted. Those fears gained credence when a pediatrics hospital in Pittsburgh attributed a higher mortality rate to ...Drug protects brain cells in Huntington's disease model, researchers find
...rug that increased brain dopamine levels performed worse on these tasks, while TBZ protected against this effect. Most importantly, TBZ appears to reduce significantly cell loss in the striatum of the engineered mice, the scientists report. More research is needed to determine whether this protective eff...Accident-prone? Scientists link brain function to knee injuries
...r reaction time and processing speed and performed worse on visual and verbal memory tests when compared to the control group. These results suggest that slower processing speed and reaction time, as well as lower visual and verbal memory performance may predispose certain individuals to errors in coordi......vents do not go away on their own, or may even get worse over time, severely affecting their lives. Treating these disorders involves methods geared toward making the behavior go away, or become extinct, but the molecular mechanisms underlying the extinction process are not well understood. However, Tsai...JCI table of contents: July 12, 2007
...phanegative cancers are more aggressive and have a worse prognosis than do ER-alphapositive breast cancers, and have been thought to be estrogen independent. In a study appearing online on July 12 in advance of publication in the August print issue of the Journal of Clinical Investigation, Joyce Slingerlan...Specific type of cell death may accelerate decompensated heart failure
...ses. Mice with amplification of autophagy fared worse in terms of cardiac stress than the mice with a muted response, Dr. Hill said. Severe stress leads to increased autophagic activity in heart muscle, and our findings are consistent with the notion that this response actually harms the heart. Resea...Complex ART procedures more likely to lead to umbilical cord abnormality
...s and twins conceived after fertility treatment do worse in terms of duration of pregnancy and in live birth weight. Certain umbilical cord pathologies, such as the insertion of the cord on the placental membranes instead of centrally in the placenta, or the absence of one artery in the cord, are known...Germany's embryo protection law is 'killing embryos rather than protecting them'
... reflect the current state of the art. It is far worse to kill embryos after they have implanted in a womans womb, than it is to take embryos before implantation, when they are no more than a collection of cells, freeze any surplus embryos and transfer no more than one or two embryos at one time. It is b...Global warming is evaporating Arctic ponds, new study shows
...e speed and magnitude of environmental changes are worse than even we imagined!...Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
...operative CA 19-9 level exceeded 180 U/ml did much worse than those with lower levels. In fact, at least half of those whose CA 19-9 level was higher than 180 U/ml lived for approximately nine months, while half of those whose levels were 180 or below lived more than twice as long, about 21 months. Afte...Cytokine resistance contributes to pathology of type 2 diabetes
...cold. They get injured. Something happens. And its worse in those people with obesity or diabetes and lasts longer than it does in others, Freund said. Why" The imbalance may be the elevation in pro-inflammation. But it probably also includes a loss of anti-inflammatory function. ...News tips from the Journal of Neuroscience
...ional deletion of HIF-1 in forebrain neurons fared worse than wild-type (WT) mice after focal cerebral ischemia. WT mice that received pharmacological activators of HIF-1 showed further improvements. HIF-1 in neurons is not the whole story of neuroprotection, however, as hypoxic preconditioning was still n...Genomic signatures identify targeted therapies for lung cancer
...pecific pathways -- called Src and Myc -- had much worse prognosis than those with defects in another pathway, called Ras. The researchers then treated the laboratory tumors with drugs that specifically blocked one of the three different pathways. In all cases, the cancer responded to treatment with the ...Gene therapy offers new hope for treatment of peripheral neuropathy
... standard pain treatments and occasionally may get worse instead of better over time. For some people, it leads to serious, long-term disability and dependence on pain medications that have a variety of unwanted side effects, including addiction. The Pitt research team, led by Joseph Glorioso, III, Ph.D....Biting discovery: MU entomologist finds host of new aquatic insect species in Thailand
...nch when they bite. "It's much, much worse than a bee or wasp sting," said Robert Sites, an entomologist in the College of Agriculture, Food and Natural Resources at the University of Missouri-Columbia. "It's actually not a sting; it's a bite. You'll be thinking about it a half hour or an hou...Hyperactivity and academic achievement could be linked by genetics
Children who are hyperactive tend to do worse academically than their peers who are not hyperactive. Although the relationship between such behaviors as overactivity, impulsivity, and inattentiveness in children and poor achievement in math, reading, language, and other areas has been well docum...