Key to zebrafish heart regeneration uncovered
...lay between a mass of stem cells that forms in the wound and the protective cell layer that covers the wound spurs the regeneration of functional new heart tissue, Duke University Medical Center scientists hav...Researchers find docking sites for glucocorticoid receptor and Hsp90
...porosis, cataracts, ulcers, hypertension, impaired wound healing, diabetes and depression. Thus narrowing the point of attack, such as by manipulating Hsp90-glucocorticoid receptor interaction, is of growing importance, Darimont said. The PNAS paper and a second publication that is under review cover the...JCI table of contents: December 1, 2006
...enesis) is essential during embryonic development, wound healing, and blood cell development in the bone ma...o limited the blood vessel growth that accompanies wound healing in response to a loss of blood flow in the tissues. The increased blood vessel growth in the...Newts which regrow their hearts
...hat the heart regeneration does not create typical wound healing tissue, called a blastema. Braun explains ...e de-differentiation comes from the area where the wound is healing and the cells communicate with each other," explains Braun. These signals could be transm...From managing sugar to managing healing
... faster"surface cells in the epidermis covered the wound more quickly and cells in the dermis, the deeper p...ls, the insulin stimulates only migration into the wound tissue. The insulin works by switching on cellular signaling proteins called kinases (specifically S...Beyond the book: Software automates access to brain atlases
...e guidance of Swanson and Thompson guidance. Cheng wound up rebuilding NeuART from the ground up, said Burns. The revised NeuARt II interface indexes the data in a variety of ways, including spatial maps and alphanumeric information, coming off a single interface. It includes all the information in the pri......e muscle weakness. The diagnosis turned out to be wound botulism. Wound botulism is a potentially fatal... University of London), says that the incidence of wound botulism following heroin injection into skin or muscle has risen dramatically in the UK since 2000....Genetically altered cells may help artificial skin fight infection
...ld become an effective alternative method for burn wound care and infection control. Using them in cultured...e early healing period by continually wrapping the wound in dressings soaked in antimicrobial drugs. Although this protects the grafts, Supp says, it can als...Rice breakthrough could prevent multiple fibrotic diseases
...bloodstream and plays a crucial role in regulating wound healing. SAP's roleis to inhibit the activity of immune cells called fibrocytes, which makeexcess collagen that the body uses to heal wounds. Gomer said the tests atRice show that maintaining an elevated level of SAP in the blood is enoughto prevent ...JCI table of contents: Feb. 1, 2007
... that occurs during development, as well as during wound healing, tissue fibrosis, and tumor metastasis, is the transition from an epithelial cell to a mesenchymal cell (often a fibroblast). This change in cell type and function is known as epithelial-mesenchymal transition (EMT) and it has been shown that...ACS News Service weekly PressPac -- Feb. 7, 2007
...f fibers that make it ideal as a dressing to speed wound healing and for a range of other biomedical applications. Microbial cellulose already has been used successfully in patients with severe burns, for instance, and as a replacement for small-diameter blood vessels, the scientists point out. Based on ...MIT bioengineer advances survival, promise of adult stem cells
...sly difficult to develop as a clinical product for wound healing. To control this, the researchers decided to tether EGF to a scaffold, preventing the stem cells from eating it up and allowing continuous EGF exposure on the cell surface. "Putting them on a scaffold is appealing because then you can con...Cancer cells forming blood vessels send their copper to the edge
...iogenesis is important in growth, development and wound healing. But it also enables the spread of tumors throughout the body, so researchers have been scrambling for ways to stop angiogenesis in the fight against cancer. One element critical to blood vessel growth is copper, a vital nutrient that plays......ary Sciences said: "This discovery is like an open wound on the surface of the Earth. Was the crust never there? Was it once there but then torn away on huge geological faults? If so, then how and why?" To answer some of these questions Dr MacLeod with a team of scientists, led by marine geophysicist Pr...Blood's clotting cells harbor 'ticking time bombs,' finding may help extend blood supply
...n as plateletswhich form blood clots and assist in wound healinghave internal clocks that act like ticking time bombs, predetermining their death from the moment they are born, according to a new study in the March 23 issue of the journal Cell, published by Cell Press. The researchers said that the findi...Natural polyester makes new sutures stronger, safer
...naturally, so they can be safely absorbed once the wound is healed. They are also 30 percent stronger than sutures now used and very flexible, making them easier for surgeons to work with. The sutures were developed by Tepha, Inc., a Cambridge company that hopes to use the same material to produce an arr...Scientists decode genome of oral pathogen
...s the bloodstream, possibly through a minor cut or wound in the mouth, it can cause bacterial endocarditis, a serious and often lethal infection of the heart. Individuals with preexisting heart problems are at an increased risk of developing bacterial endocarditis. The infection may result in impaired he...A relative of anti-aging gene Klotho also influences metabolic activity, obesity
...in many tissues that are involved in tasks such as wound care and skeletal development. Certain fibroblast growth factors are active only in fat cells, but it hadnt been known why. The UT Southwestern researchers discovered that beta-Klotho, which is active in fat cells, actually binds to receptors for...Breast cancer milieu -- Progression, tamoxifen sensitivity, and DNA reversion
...s thought to be critical for cell migration during wound healing. However, loss of Fibulin-2 in breast cancer may lead to changes in the environment surrounding, and confining, cancer cells, thus enabling cancer cells to migrate from their original site to other locations. Fibulin-2s potential involveme...