Linking empires, economics, evolution
...portionate influence of the rich and powerful," he writes in the preface to the book. Human society is still following rules established billions of years ago, and nothing suggests that we can change that direction, Vermeij said. But our ability to anticipate and learn may help us to find ways to survi...Gene expression profiling aids in ovarian cancer prognosis
...for clinical trials [of investigative therapies]," writes Cannistra. "It may also provide insights into why tumors frequently develop resistance to chemotherapy, and may eventually permit individualized use of targeted therapies that are chosen on the basis of a given tumor's genetic profile," he notes. ...Spider silks, the ecological materials of tomorrow?
...ned that allow bacterial synthesis at high yields" writes Scheibel in the article*. Engineering new proteins would also allow the design of completely new types of silk fiber, which could assemble with biochemically or biologically active groups into new types of mesh. These 'intelligent' materials would th...Stem cell therapy for ailing hearts
...n holds great promise for treating heart failure," writes David Stern, MD, dean of the Medical College of Georgia, and colleagues in the Cell Transplantation editorial accompanying the USF study. "Additional preclinical animal studies are warranted and should focus on examining the mechanisms that mediate t...Combination therapy boosts effectiveness of telomere-directed cancer cell death
... the potential risk of acquired drug resistance, " writes Dr. Seimiya. Hiroyuki Seimiya, Yukiko Muramatsu, Tomokazu Ohishi, and Takashi Tsuruo: "Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics" The context and implications of this work are discussed in a Preview by Shay et al. T...Genetic testing for Parkinson's disease on the horizon
...luating the risks associated with the mutation. He writes that genetic testing for the new LRRK2 mutation will also raise ethical issues. Due to the absence of preventative treatment, testing offers no direct medical benefit for patients....AAAS announces winners of the 2005 Fellowships for Reporters from Africa
...bacar , Jeune Afrique Economie , Senegal Boubacar writes for the French-language magazine Jeune Afrique Economie, where he covers science and health, among other topics. The winners will receive support to travel to Washington, DC, from 17 February until 21 February, to report and train at the 2005 AAAS A...HHMI professor, 138 undergraduates identify essential genes in eye formation
...ross-breed flies. As a mid-term exam, each student writes an NIH-style grant proposal for original research. The final is a scientific paper that summarizes the research findings. Innovative undergraduate courses such as this, bringing education and research closer together, are the kind of transformation o...New drug shows promise as powerful anticancer agent
...t way to utilize ON01910 in human cancer therapy," writes Dr. Reddy. The other members of the research team include Kiranmai Gumireddy, M.V. Ramana Reddy, Stephen C. Cosenza, R. Boomi Nathan, Stacey J. Baker, Nabisa Papathi, and E. Premkumar Reddy of Temple University School of Medicine; and Jiandong Jiang ...Scientists identify molecule that regulates well-known tumor suppressor
... from upregulated PKB/Akt-mediated cell survival," writes Dr. Mak. Elevated DJ-1 levels may explain why some tumors without PTEN mutations exhibit enhanced PKB/Akt activity. The authors go on to suggest that DJ-1 may be a prognostic marker for cancer patients and be useful as a target for development of fut...JCI table of contents April 1, 2005
... commentary, G.R.Scott Budinger and Jacob Sznajder writes that these studies will "influence future investigations into the molecular mechanisms by which these [A1] pathways become activated to contribute tolung injury." TITLE: Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of c...To sea or not to sea: When it comes to salmon sex, size sometimes doesn't matter
...salmon or has been altered to their detriment," he writes in the conclusion of his book published by University of Washington Press. "However, if we write salmon off as incapable of recovery and so justify actions and inactions that harm them, we will turn our pessimism into their reality, and that would be...Chemokines orchestrate more than migration for immune cells
...regulate their ability to prime T cell responses," writes Dr. Bachmann. A clear understanding of the influence of these chemokines on T cell immune responses will be useful for rational design of future antiviral and anticancer therapies....JCI table of contents May 2, 2005
.... In an accompanying commentary, Francis Glorieux writes that these data "represent an important step forward in the understanding of the pathology of an elusive disorder." TITLE: Novel COL1A1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders ...JCI table of contents June 1, 2005
...isease. In an associated commentary, William Mitch writes that "the development of molecules capable of preventing these regulatory abnormalities holds the promise of eliminating the contribution of anorexia to the development of cachexia." TITLE: Role of leptin and melanocortin signaling in uremia-associat...Study shows eutrophic lakes may not recover for a millennium
...substantial changes in soil management," Carpenter writes in PNAS .The amount of phosphorus that runs into the lake in any given year is small, the Wisconsin scientist notes, but a little bit of the nutrient is all that is needed to send aquatic ecosystems into overdrive. Carpenter's model also shows that...New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
...ch the anti-GSL T cell response may be important," writes Dr. De Libero. The authors suggest that although the autoreactive T cells may play a useful role in promoting the immune response to infection, in the absence of infection the GSL autoreactive T cells might seek out the abundant "self" GSLs that can...Stephen P Goff awarded inaugural Retrovirology Prize
...etrovirus research. Editor-in-Chief Kuan-Teh Jeang writes about the award in an editorial published this week in the Open Access journal Retrovirology. The editorial includes an interview with Goff, about his career, inspirations and achievements. The Retrovirology prize, which will be granted annually, re...Nitrogen in the air feeds the oceans
...tic, biological N2 fixation is indeedsubstantial," writes Nicolas Gruber of the University of California,Los...el of confidence inthe estimates obtained," Gruber writes in Nature. The study has implications for climate science. An old misconception, even within the sci...Treatments have same target, different responses for lung cancer patients with genetic mutation
...rugs should, theoretically, block EGFR signaling," writes John D. Minna, M.D., of the Hamon Center for Therapeutic Oncology Research at the University of Texas Southwestern Medical Center in Dallas, and colleagues in an accompanying editorial. "The first round clearly was won by [drugs such as gefitinib]."...