Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
...uickly, because if the bacteria reproduce with the wrong methylation pattern, gene expression will be foiled and they will lose their virulence. "For the first time, using the 3-D crystal structure, we have been able to see the specific Dam structure in action, including the way it binds to the DNA and mov...Important brain finding results from boy's rare, fatal disease
...from a patient and use them to learn what is going wrong in the brain of a patient with a complex neurological disease. The team of scientists from the University of Rochester Medical Center reported its results in the March issue of the prestigious research journal Nature Medicine. "This family's generos...Scientists develop technology to detect cancer
...control this may switch the gene on or off at the wrong time in the cell cycle. Dr Lakis Liloglou, Head of the University's Lung Cancer Molecular Biomarkers Group, explains: "This is of particular importance in lung cancer research, as the changes in methylation status of the DNA are considered to be a ...Overworked brains release adenosine to slow cells, trigger sleep, UT Southwestern researchers find
...ep, we can start to understand what might be going wrong when we don't." Showing that increased brain cell...f waking and the need for sleep. If something goes wrong with this adenosine system, you may end up with insomnia." Other UT Southwestern researchers on the...Method shows how precisely gene expression signals are copied in DNA replication
...hat, in the case of fragile X, is happening at the wrong place at the wrong time," he said. "It's a basic process, but it's not fully understood." The new method lets the rese...New study explains process leading to many proteins from one gene
...e improperly splicing out an exon, thus making the wrong protein, Dr. Garner said. His research group has previously shown that these sequences are highly variable in cancer, and he said the new findings could go a long way toward understanding the genetic nature of how cancers start and progress. "With t...Schizophrenic antifungal bacteria
...cinal and the non-medicinal forms tips too far the wrong way, the bacteria can no longer adequately control the fungal infections. Although more than 100 crop protection products based on microorganisms are available throughout the world, bacteria are still not widely used in these as they are not reliabl...Why do amyloid diseases strike different tissues?
...y and Balch answer that quality control may be the wrong concept. You can't think just about the thermodynamics of the protein, they say. Kelly and his colleagues did find, however, that both the thermodynamic AND the kinetic stabilities of the TTR mutants taken together contribute to the energetics of the...At the molecular level, the predator is the prey
...uthors. "If the channels change too much or in the wrong way, they can't perform their basic, everyday functions. Sodium channel genes in different vertebrates are virtually identical to each other, but not in these snakes. We're finding a molecular arms race is driving rapid and repeated changes in the ge...To train the eye, keep it simple
... California and UC Irvine suggests common sense is wrong in this case. The human vision system learns best in "clear display" conditions without visual noise, said co-authors Zhong-Lin Lu and Barbara Anne Dosher. Their findings appear in a pair of articles in the current issue of PNAS. The research has lon...Determining the fate of cells in the human body
...yndrome. "By studying a disease in which things go wrong at the cellular level, we gain insight into how to correct these errors," said Dr. Firulli, who also is a molecular biologist at the medical school's Herman B Wells Center for Pediatric Research. "From a pediatrics perspective -- there are many con...Survivors to revisit the polio scare
...a Boston shipyard; if a porthole was opened at the wrong moment, the patient would have his breath knocked out of him. Former patients can describe living in respirators for months on end, never leaving to be bathed or changed, eating flat on their backs, relying on nurses to feed them and mirrors to see a...Insight into DNA's 'weakest links' may yield clues to cancer biology
...may ultimately help us better understand what goes wrong in cancer cells, an important step in developing a better plan of attack against the disease," Petes added....FSU anthropologist leads incredible journey through 'hobbit' brain
...'d expect to find in pygmies, and the shape is all wrong to be a microcephalic. This is something new." The brain study supports the notion that the evolution of Homo floresiensis, a new species but closely related to Homo erectus, either reflected island dwarfing in response to limited food supplies or in...Researchers discover a good side to cholesterol in controlling cell signals
...doesn't have enough cholesterol, the cell gets the wrong information, and disease results." The cell membrane, which is fluid in nature, contains cholesterol. Dr. Anderson's research focuses on regions of the membrane where cholesterol is enriched. These regions, called lipid domains, are more rigid than ...MGH study identifies potential Alzheimer's risk gene
...n the patients. "Now we need to figure out what's wrong with too much ubiquilin-1 and with this different form," says Tanzi. "We need to look at how this variant interacts with the presenilins and what effect that may have on the production of A-beta," the protein that accumulates in the amyloid plaques ...New slant on vision research: Neurons sensitive to viewing angle
...ection as the adapting image, the subjects guessed wrong half the time, saying the test image was turned in the other direction. The reason for the errors is that when a person stares at an image, neurons that respond to the viewing angle of the image get "tired" and become less responsive when a very sim......rchers have been thinking about whale herds at the wrong scales, which has been constrained by the limitations of their recording and visual observation abilities. Suddenly you realize that the whales sense of scale is ocean basin sized one song note is 20 miles long and can illuminate the entire basin, he...Secrets of whales' long-distance songs are being unveiled
...lize that he has been thinking about whales at the wrong time scale. "There is a time delay in the water, and the response times for their communication are not the same as ours. Suddenly you realize that their behavior is defined not by my scale, or any other whale researcher's scale, but by a whale's sen...Brain region learns to anticipate risk, provides early warnings. suggests new study in Science
...nable to change gears in time to avoid pushing the wrong button. They then adjusted the delay time over many trials so that each participant eventually exhibited error rates of about 50 percent when provided with an initial blue priming dash, compared with error rates of only 4 percent when presented with ...