Zeroing in on progeria: How mutant lamins cause premature aging
...sults reveals mutant LA proteins turning up in the wrong place--too tightly linked to the membranes of the nuclear envelope--to be of much help during key stages of the cell cycle. The researchers believe that this localization failure of mutated LA proteins would severely compromise the ability of HGPS ce...Researchers discover a protein responsible for shaping the nervous system
...e excess cells by eliminating those that go to the wrong place or form weak or improper connections. If this process does not happen, the nervous system cannot function properly. The expression of the p63 protein guides the nervous system in disposing of the ineffective nerve cells. The protein is from the...MicroRNA may have fail-safe role in limb development
... you not only want to shut the faucet tight on the wrong cells, you want to shove a towel into it, too, to really make sure the wrong thing doesn't leak out. One way of doing that is with microRNA." Researchers looked at gene activity...Polymer gel can block toxic leakage problem in gene therapy
...rom being diverted through the blood stream to the wrong targets, the scientists reported in research journals. "With this method we can reduce the misdirected virus dissemination by a factor of 100 to 1,000 times," said Fan Yuan, an associate biomedical engineering professor at Duke's Pratt School of Engi...Scholar uncovers the story behind the 'obesity epidemic'
...ublic health officials and doctors are sending the wrong message that being heavy, even if you exercise and eat right, is unhealthy while being thin, even if you smoke or starve yourself, is good. As a result, Oliver contends, millions of Americans are putting their health at risk with fad diets, dangero...Calls for improved screening of colorectal cancer in Europe's aging population at ECCO 13
...tly renewing themselves and when this process goes wrong abnormal cells can arise. These cells form polyps which can eventually turn cancerous. Some of these polyps are non-cancerous but others can spread through the bowel layers and to other parts of the body, often the liver. Symptoms experienced include...Engaging prior learning on creationism and evolution may benefit college biology students
...hing ID or creationism in a science class would be wrong unless these notions were critiqued scientifically and compared to evolutionary explanations. As many high-school teachers are not well prepared to rigorously contrast creationist and evolutionary accounts, Nelson writes that it would be "quite inapp...Picky female frogs drive evolution of new species in less than 8,000 years
...ng were less viable. To avoid hybridizing with the wrong frogs and ensure healthy offspring, one group of females preferentially chose mates from their own lineage. Over several thousand years, this behavior created a reproductively isolated population - essentially a new species - that is unable to mate w...DNA size a crucial factor in genetic mutations, study finds
...10,000 to 100,000 times the enzyme will put in the wrong base, choosing for instance a G instead of a T to pair with an A. The rate that the enzyme accurately copies DNA is known as its efficiency. These rare and random mistakes can cause genetic mutations. While we tend to heap negative connotations onto ...Humans are governed by emotionsliterally
...ion warn the deliberative system that something is wrong and that its capabilities are required. Perversely, as emotion intensifies, however, it tends to assume control over behavior even as it triggers the deliberative system, so one may realize what the best course of action is, but find one's self doing...Your brain cells may 'know' more than you let on by your behavior
...at happened in the brain when the monkeys made the wrong choice, although they had apparently learned the r...cells kept firing even when the monkeys picked the wrong symbol. "In this sense, the cells 'knew' more than the monkeys let on in their behavior," says Albri...Radical approach to cardiac resynchronization shows promise
... heart's outer surface, or if the veins are in the wrong position, we can't give optimal therapy," explained Fred Kusumoto of the Mayo Clinic, Jacksonville, Florida, a senior author on the paper. "With this technique, if it proves fruitful, we can put the leads anywhere." When Mickelsen first ran his idea...Restoring silenced suppressor gene kills lung-cancer cells
...l process known as methylation. "There is nothing wrong with those genes except that they are silenced by methylation," Huebner says. "Experimental drugs are now being tested that cause demethylation and may reactivate WWOX and other genes." For this study, Huebner and her colleagues used three different...FSU biologists describe key role of signal-transcribing gene during cell cycle
...hanisms that drive cell cycle behavior and fate go wrong along the critical Notch pathway a communication channel already associated with the genesis of several genetic and neuromuscular diseases; the most common complex congenital heart disorder; and later life ills such as Alzheimer's, breast and lung c...... made from a mutant gene usually has an EJC in the wrong position, which activates NMD and destroys the RNA before it can be used to make flawed proteins. Andreas Kulozik and Matthias Hentze, who jointly run the MMPU, have now discovered that the EJC can be put together from different components, and this ...What we cannot do ourselves, we cannot understand in others
...ether the person in the video had the right or the wrong expectation regarding the weight of the box. Again, the only source of information for the patients to make their judgment was body movement. If the people in the film were deceived about the weight of the box, they tended to show a characteristic di...Study points to molecular origin of neurodegenerative disorders, including Huntington's disease
...derlying molecular etiology. And if something goes wrong at the organism level, it also goes wrong at the molecular level. We try to understand the dynamics and the change in structure that occurs in...Hopkins scientists uncover 'tags' that force proteins to cell surface
...ucture, but that's what most scientists think goes wrong if a protein doesn't go to the surface," says Li. "But now we know the problem might just be a faulty transportation signal." Given that proteins can be thousands of building blocks long, the final eight building blocks may not seem to be very import...Sugar helps control cell division
...leus a "wrinkly" appearance. Exactly what is going wrong is still unclear, adds Gerald Hart, Ph.D., professor and director of biological chemistry. He's been studying O-GlcNAc since his lab discovered it attached to proteins inside cells 20 years ago. They now know which enzymes put the sugar onto proteins......ria. This may well be the signal that something is wrong with the cell and may be a reason why some patients who are injured or infected go on to develop organ failure." With that knowledge, scientists may be able to look at new ways to re-establish stability within the cells and avert the negative consequ...