Tag: "yeast" at biology news
Longevity controlled by calorie quality, not quantity
...ng the nutrients in the fly's standard lab diet of yeast
and sugar to a level known to maximize life span. Since both yeast
(which contributes protein and fat) and sugar (carbohydrates) provide the same calories per gram, th...
More than 'SNARE' needed for proper synapse
...ophysiology, biochemistry, electron microscopy and yeast
trans-species experiments, they determined that Vha100-1 was involved in membrane fusion and played a critical role in the release of a neurotransmitter after the action of the SNARE proteins. Others who participated in the research include Drs. Amir...
To stop evolution: New way of fighting antibiotic resistance demonstrated by Scripps scientists
... to identify the genes in Saccharomyces cerevisiae yeast
and human cells that induce mutations that can transform normal cells into cancer cells. ...
Location, location, location: Effect of nuclear organization on transcriptional status
...oignant example of how the nuclear organization of yeast
genes change when the cell undergoes a dramatic switch in its transcriptional program, Dr. Silver and colleagues treated S. cerevisiae cells with the mating pheromone, alpha factor, and then used genome-wide location analysis to observe that alpha-fa...
Researchers map 'circuitry' of yeast genes using technique that could be applied to humans
...information contained in the 16 chromosomes of the yeast
Saccharomyces cerevisiae into a wiring diagram res...oach allowed them to predict new functions for 343 yeast
proteins based on their positions in the new wiring diagram. "Beyond deciphering the circuitry of a ...
UCR chemist part of team identifying new areas of gene regulation
... part of a team that has discovered a new way that yeast
governs genetic expression and repression, a findi...ntify a novel acetylation site at the lysine 56 of yeast
histone H3," said Zhang, referring to the previously unknown location of a chemical opening to allow...
Molecular models advance the fight against malaria
...ide. The scientists developed disease models using yeast
and successfully introduced five mutations that ma...ues continued their work on previous studies using yeast
enzymes to explore atovaquone resistance. It is not possible to grow enough malaria parasites to is...
Buying time through 'hibernation on demand'
...d subsequently re-animate such model organisms as yeast
and worms, as well as the embryos of fruit flies and zebrafish. In each case they achieved metabolic suspension through oxygen deprivation caused by exposure to gases such as hydrogen sulfide and carbon monoxide. Known as oxygen mimetics, these chemi...
Study reveals candidate targets for anti-retroviral therapeutics
... these mobile elements (called Ty or transposable yeast
elements) encode proteins that are homologs of re... by Ty elements and the steps of the life cycle in yeast
are similar to the proteins encoded by retroviruses and their life cycles in animal cells. Scientis...
Ancient enzyme guides healthy eating in mammals
... favor of a more balanced meal. The same enzyme in yeast
also acts as an amino acid sensor, earlier work has shown. "This ancient pathway in mice recognizes drops in blood amino acid levels that occur following consumption of food with an imbalanced composition," said Ron. "That recognition culminates in a...
Researchers unmask malaria parasite's cloaking mechanism
... already known to play a role in gene silencing in yeast
by modifying gene packaging. To examine the potential role of SIR2 in silencing var genes, the scientists created a parasite that lacked a functioning gene for that protein. They found that the genetically-altered parasite expressed a greater number...
Researchers improve design of genetic on-off switches
...or Genomic Biology at Illinois. Zhao's team, using yeast
and mammalian cells, altered the specificity of human estrogen receptor alpha by 100 million times so it would bind preferentially to a non-toxic synthetic molecule (4,4'-dihydroxybenzil) over the natural estrogen 17-beta-estradiol. Such selectivity ...
Fibril shape is the basis of prion strains and cross-species prion infection
...y "strains" of disease prions across mammalian and yeast
species. Researchers thought these strains could b...s the determining factor in whether one species of yeast
could infect another yeast
species. Just as in the case with the preseeded mice fibrils, a particula...
Protein tags regulate key ion channel
...nown as background (or leak) potassium channels in yeast
cells in 1995 and in fruit flies in 1996. Although potassium leak was first described in the 1950s when it was recognized to control excitation of nerves, the reason for leak had not previously been understood. The first human clone of this channel,...
Researchers identify potential therapeutic target for Huntington's disease
Researchers studying yeast
cells have identified a metabolic enzyme as a potential therapeutic target for treating Huntington's disease, a fatal inherited neurodegenerative disorder for which there is currently no effective treatment. The group, whose results appear in the May...
Yeast discovery gives insight into familial dysautonomia
...EASE: April 6, 2005 ITHACA, N.Y. -- A discovery in yeast
that has important implications for finding a cure... and two of her graduate students was to study how yeast
establishes cell polarity by directing new growth to an area of the cell membrane where a "bud" can ...
Natural tumor suppressor in body discovered by UCSD medical researchers
...mical signaling proteins in organisms ranging from yeast
to humans. Once they found PHLPP, which they discovered was expressed throughout the body, the scientists used biochemical and cellular studies in human and other mammalian tissue to determine that PHLPP levels are markedly reduced in several colon...
Urine helps infectious yeast stick
... discovered that urine actually helps a particular yeast
stick to cells along the urinary tract. The findin... might offer a new way to prevent or treat certain yeast
and fungal infections, and the researchers' work also provides an unexpected new role for some prote...
Yeast finding links processes in heart disease and cancer
By studying a little-known yeast
too primitive to get diseases, Johns Hopkins resea... disease and cancer in people. In experiments with yeast
known as S. pombe, the researchers discovered that a gene that helps the organism make cholesterol a...
A regulatory network analysis of phenotypic plasticity in yeast
... that they are lost over evolutionary time. In the yeast
gene regulatory network, some genes are turned on ...ecological relevant traits. Promislow analyzes the yeast
gene regulatory to understand how genes influence phenotypic plasticity. 'Phenotypic plasticity' ref...
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