Researchers create functioning artificial proteins using nature's rules
...be to put them back into a living organism such as yeast or fruit flies and see how they compete with natural proteins in an evolutionary sense." Other UT Southwestern researchers involved in the work are lead authors Michael Socolich, HHMI research specialist, and Dr. William Russ, assistant instructor of...Northeast Sun Grant Institute at Cornell spurs 'green revolution'
...mes; enhancing ethanol tolerance and production in yeast through understanding and manipulating membrane restructuring; converting dairy manure-derived biogas from anaerobic digestion to produce electricity, hydrogen and heat on dairy farms; utilizing used vegetable oil from restaurants to replace diesel ...Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
...ibians, marsupials, and even bacteria, viruses and yeast retained a greater ability to repair such damage. Since the 1940s, scientists have been trying to understand how the DNA in plants and some animals can be damaged by UV light, and then seemingly repaired by visible light. In the 1960s, they identi...Prions rapidly 'remodel' good protein into bad, Brown study shows
...iochemistry, conducted the research using Sup35, a yeast protein similar to the human prion protein PrP. Th...ery, very rapid change." After the conversion, the yeast cells remained healthy but had new characteristics. This survival supports the theory that prions ha...New study to explore cellular circuitry
... a type of yeast. Although a single-celled fungus, yeast shares many genetic traits with humans, making it ... Biophysics have designed a one-of-a-kind "genomic yeast library" that allows for high-speed, systemic examination of the purpose of each protein in the yeas...Researchers discover new route to hemoglobin synthesis
...und in the scientific literature that this gene in yeast was required for the production of iron-sulfur clu... conserved," said Zon. "But the difference is that yeast do not make hemoglobin. So we needed to figure out a mechanism that would explain why these fish tha......icing. The researchers found that deletion of the yeast gene ISY1 reduces the efficiency of the first step of the splicing reaction and decreases 3'-splice site accuracy. Dr. Villa and Guthrie believe that Isy1p interacts with the ATPase Prp16p to regulate spliceosomal conformation, and thereby the fideli...Study yields insights into pathogenic fungiand beer
...sible functions they might offer, by using baker's yeast as a model. Verstrepen scanned the entire yeast genome with a custom computer program developed by Whitehead's bioinformatics group. He discovered t...Family of life-extending genes discovered
BOSTON Mice, rats, worms, flies, and yeast all live longer on a low-calorie diet, which also ... low salt, heat, or extreme calorie restriction, a yeast "master longevity regulator" called PNC1 stimulated Sir2 activity. This new work, led by Harvard gra...Improved statistical tools reveal many linked loci
...elements that produce specific traits. In brewer's yeast alone, Storey and colleagues found that 37% of gen...n two genomic locations control about one in seven yeast expression traitsXwhich Storey et al. discovered using their method. Although the g...Researchers identify gene's role in suppressing longevity
...ts from other research groups that showed that the yeast version of the gene, Sir2, extends the ability of ...That was quite surprising, because the findings in yeast and other lower organisms led those in field to speculate that if you got rid of mammalian SIRT1, th...Landmark comparative genomics study highlights the importance of 'junk' DNA in higher eukaryotes
...in the genomes of vertebrates, insects, worms, and yeast to date. One of their major findings was that as...e species of mosquito. Two worm species and seven yeast species rounded out the set. To help ease the gargantuan task of identifying conserved elements in m...North & South American researchers find architectural abnormalities in T. cruzi ribosome
...t organisms. "In reconstructions of ribosomes from yeast to rabbits to humans, one essentially sees the same architecture," said Frank. "It lulled us into the belief that once you've seen one ribosome, you've seen them all. It was a total surprise to see such a different structure." Last year, Levin trave...Researchers get first peek at amyloid's spine
...of the shared core feature. In this case, it was a yeast prion, a misfolded protein that has the additional... Nelson, a graduate student. Unlike in people, the yeast prion causes a condition which may be beneficial. In people, scientists do not know the role of the ...NHGRI selects 13 new targets for large-scale sequencing program
...uirts, two roundworms, over a dozen fungi, baker's yeast and the bacterium Escherichia coli. Organisms currently in the NHGRI sequencing pipeline include: the macaque, the orangutan, the cow, the platypus, the red flour beetle, several additional species of fungi and the domestic cat. A complete list of or...'Molecular zipper' may hold important clues to Alzheimer's, Parkinson's and mad cow disease
... of a small piece of a fibril-forming protein from yeast that behaves similarly to proteins involved in Alzheimer's and these other diseases. Knowledge of the structure of this small peptide -- known by the code of its amino acids, GNNQQNY -- reveals a surprising "molecular zipper" that Eisenberg described...Unweaving amyloid fibers to solve prion puzzles
...eal prion. To do this, Krishnan took a variety of yeast prion strains and modified them in such a way that...th tails. Remarkably, the same prion from the same yeast species could sometimes fold differently, and this fold would form its own cascade of interactions. ...After the yeast is gone bacteria continue to develop flavor of sparkling wine
...g wine production requires addition of sucrose and yeast strains to the base wine for a second fermentation...eted the Cava wine is aged in the bottles with the yeast for at least nine months, or longer for premium quality wines. During aging, substantial chemical ch...New technique helps identify multiple DNA regulatory sites
...tory sites for about one-third of the genes in the yeast genome a success rate as good as or better than other current techniques. "The next step is to test this approach on different organisms, including microbes and vertebrates," Fidelis said. The growing number of organisms whose genomes have been sequ......pped multiple complex biological interactions in a yeast cell in a simple graphical form, enhancing our und...ent types of biological relationships found in the yeast Saccharomyces cerevisae: protein-protein interactions, genetic interactions, transcriptional regulat...