Discovery Hints At Multitude Of New Targets For Drugs
...ng rise to one response.And it might interact with another set in another cell, giving rise to awhole different set of responses." McDonnell said the discovery with ...Tacrolimus Stops Rejection Of Kidney Transplants
...controllable rejection. It halted kidney damage in another 11 percent. Only 11 percent of patients given tacrolimus experienced progressive deterioration of the transplanted kidney. These results indicate that overall, tacrolimus therapy may reduce the 10 to 15 percent of kidneys that are lost to repeated or...Scientists Produce New Anti-Malarial Compound
...Health . That grant was recentlyrenewed by NIH for another four years. Also involved in the workare Xueliang Tao, a postdoctoral fellow in chemistry; Jared N.Cumming, a chemistry graduate student; and Donna Klinedinst, aresearch assistant in the Johns Hopkins School of Medicine....Hospital Noise Disrupts Sleep For Patients, In The Critical Care Setting
...ousals in one patient during a one-hour period. In another patient, 34sound peaks were correlated with 42 arousals in one hour. Medical personnel aren't sure how disrupted sleep affects elderly patients.Some studies show that at least one-third of sleep-deprived hospital patientshave what is called "ICU ps...ACTG 315 Preliminary Results: Drug Cocktail Restores Partial Immune Function
... more naïve cells (those not exposed to HIVor another antigen before), while naïve cells are primarilyresponsible for the rise in CD8+ T cells. Meanwhile, the percentageof activated CD4 and CD8 T cells fell, and average plasma levelsof TNF- (tumor necrosis factor alpha, a protein that is usuallyve...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...mentby using a technique pioneered in the 1950s by another professor now atDuke. This method takes advantage of the fact that isotopes -- different formsof the same atomic element -- have very similar but not identical properties.So while hydrogen can link up with oxygen to form normal water, its heavi...Laser Offers Hope For Heart Patients With No Alternatives
...center since October. "The laser gives us another tool for helping patients for whom wecould do nothing else," said Duke surgeon Dr. James Lowe, who headsup the Duke investigation. "These patients typically have had multiplehospital admissions, they can't work or exercise and physical exertion ofany...New Approach To Multidrug Resistance
...window takes about 24 hours, and it stays open for another 72 hours -- and that's the period when the second drug is most effective," says Hamilton.The researchers report similar results in drug-resistant cells derived frombreast, colon, liver, leukemia and brain tumors. Preliminary results fromanimal and h...Many Medical Screening Tests May Be Unnecessary.
...efuse to provide the test, or refer the patient to another doctor who will provide it. This education and negotiation process is intended to apprise the patient about which screening tests have been proven to be beneficial and which have not. Such a discussion can result in patients making informed and lea...'Bathtub' Equation Aids Diabetes Research
...he function of the insulin-producing betacells and another that may help to prevent the disease by smoothing outfluc-tuations in the blood sugar level. Finegood is optimistic about the progress of diabetes research. "I'msometimes shocked at how much we know about some things and how little weknow about certa...NIH Honors Emory Researcher With Merit Award For Work On Renin-Angiotensin System
...he very basis of whatmakes one cell different from another cell," says Bernstein. "By understandingthe function of testis ACE, we get a real insight into the basic makeup of whatwe are, which is a creature of many different tissues, each of which isresponsible for a functionality." Bernstein's curren...Affordable, Hand-Held Biosensor For Diagnostics
...olve the recognition andbinding of one molecule to another partner molecule. In their tests, for example, the biosensor was able to match tinyconcentrations of specific DNA sequences to its complementary strand, suggestinga potential role for a variety of genetic studies and tests, including DNAfinge...Princeton Plasma Physics Laboratory collaborates with USDA in development of pasteurization process
...ds such as eggs, fruit juices, and milk. "This is another example of applying our fusion and plasma science capabilities to an area that benefits the U.S. public," said PPPL Technology Transfer Head Lewis Meixler. The $120,000 agreement between the two federally funded agencies came about after researcher...Some Good News In Treating Infection Common To HIV Patients
...died and one patient had to discontinue because of another illness. Attempts to determine the mechanism of desensitization were unsuccessful. Despite this, Kazanjian says the importance lies in the successful long-term desensitization of a vast majority of the patients previously allergic to Bactrim. "It's ...Cardiovascular Costs, Deaths Projected To Rise In 1998
...ad todiabetes." High blood cholesterol is another major risk factor for cardiovasculardisease, the American Heart Association reports. About 96.8 million American adults, or 51 percent of the population,have blood cholesterol levels of 200 milligrams per deciliter (mg/dL) andhigher. A readi...Chemists Closing In On Commercial Potential Of Alkanes
...l of one ofthe earth's most plentiful materials is another step closer to realization.Using ultrafast spectro...own for detailed study, Bergman and Bradley Moore, another chemist who alsoholds a joint Berkeley Lab-UC Berkeley appointment, conducted experiments inliquefie...Researchers Study 'Natural' Screen For Cancer
...nce Council. Measuring light is the key to another of Rawicz's group projects -- adental color analyzer, which he expects to soon produce commercially. Theanalyzer allows for a precise match of dental material for reconstructive work on teeth, which, like skin, are translucent. "Our impression...Study Finds Incidence Of Stroke Over 40 Percent Higher Than Previously Stated Figures
...rst-ever stroke," adds Broderick. "Whensomeone has another stroke, it's a huge burden to the healthcare system. Theburden of recurrent strokes is an understated problem. Even if our rates did notchange at all, our numbers will increase as people live longer. "These new numbers in our report emphasiz...Heart Attack Survivors Can Lower Stroke Risk By Taking Cholesterol-Lowering Drug, Study Says
..." LDL cholesterol. The study also yielded another tantalizing finding. In the main CAREstudy, researchers found that people whose "bad cholesterol" readings were below125 mg/dl did not benefit from taking pravastatin in terms of a reducedheart-attack risk. This "threshold" effect, however, was not f......"Folz said. Physicians have known about another toxicity to lungs from high-dosechemotherapy and BMT, called idiopathic pulmonary syndrome (IPS), which occursmuch sooner in cancer treatment, is more severe, and does not respond to steroidtreatment. The main difference between the Duke p...