Tag: "cell" at medical news
Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...bypass the leptin brain circuit and target the fat cell
itself. Duke researchers say their study, report...s the leptin system altogether and work at the fat cell
site itself.The B3-adrenergic agonist would stimulate the receptor on fat cells and initiate the bur...
Shark-Liver Substance May Slow Growth Of Brain Tumors
...ntrolled growth of blood vessels fuels the runaway cell
growth of malignant tumors. Other investigators al...ilage. Squalamine dramatically slowed blood vessel cell
growth without damaging healthy cells, according to Henry Brem, M.D., co-author of the studies and d...
Discovery Hints At Multitude Of New Targets For Drugs
...gs plug into the human progesteronereceptor in the cell
supports a new and different view of how drugs andhormones act on steroid hormone receptors that trigger cellular responses. The new view holds that steroid receptors are not merely on-off switches,but are far more complicated molecular "con...
Fertilization Protein Structure To AID in Leukemia Treatment
...nts that occur at the molecular level when a sperm cell
joins with an egg are often the same throughout th...like cyclase, CD38 has a tail reaching across the cell
membrane, providing a means for it to transmit signals to the inside of white blood cells. "By modi...
Means To Predict Which HIV+ Infants Will Rapidly Develop AIDS Outlined By Emory University Researchers
...defects and characteristically low CD4+ and CD8+ T cell
counts, as well as low CD5+ B cells. These B cell...D8+ T cells counts, as well as by obtaining CD5+ B cell
counts, as early after birth as possible. Newer tests being developed by the Emory group involving ...
NIAID Stops AIDS Study Prematurely Because Drug 'Cocktail' Boosts Survival
...ssigned to different treatment groups, all had CD4 cell
counts below 200 per cubic millimeter of blood when the study began, while a normal count is above 500 per cubic millimeter. "This new study is the first clear demonstration that, as we expected, the three-drug cocktail actually improves survival am...
ACTG Protocol 185 Enrollment Halted
... women with more advanced disease and lower CD4+ T cell
count than had Pediatric ACTG Protocol 076, the 19...l enrolled HIV-infected pregnant women with CD4+ T cell
count less than or equal to 500/mm3 who were receiving AZT during pregnancy for medical indications....
MRI-Guided Cancer Surgery
...osition of the probe with MRI guidance and monitor cell
death as it happens," he said. "We can also guard against damaging vital structures." The procedure relies on a Siemens open MRI machine coupled with a high-resolution, shielded LCD monitor. Duerks group has rewritten the software that drives...
Researchers Gain Insights Into Drugs Used For Manic-Depression
...stimulate release of a chemical thattriggers brain cell
activity responsible for helping control the wild moodswings of bipolar disorder. Used together, the drugs may achieve a desiredoutcome without causing dangerous side effects. Some three million Americans suffer from bipolar disorder,consist...
Milk Extract May Heal Wounds And Smooth Wrinkles
...rs are naturally occurring chemicals which promote cell
growthand skin repair, he says. The purified whey powder also contains other substanceswhich boost the growth factor's healing powers. Dr Belford says the world market potential for such a healing stimulantis enormous, perhaps as much as $10-20 bill...
Duke Obtains FDA Designation For Pompe Disease Therapy
...cally engineered form of the enzyme, expressed ina cell
line developed in the laboratory of Dr. Y.T. Chen, chief of the Divisionof Medical Genetics in the department of pediatrics. Initially, the drug will be tested in a small number of Pompe diseaseinfants to evaluate the safety and efficacy of the reco...
'Bathtub' Equation Aids Diabetes Research
...d and howthey died. The model predicted a phase of cell
death in young, normalgrowing rats. Further research proved the prediction to be true. "Just thinking about the numbers and using some basic principles allowed usto learn something of the physiology that no one ever considered, and thatno one had eve...
NIH Honors Emory Researcher With Merit Award For Work On Renin-Angiotensin System
...ed by the AT1 receptor to send messages from the cell
surface to thecell nucleus. In response to angiote... thiscascading pathway, messages are sent from the cell
surface to the cell
nucleus.Although receptors for several other kinds of cell
mediators are known t...
Researchers Finding May Boost Effectiveness Of Anti-HIV Drugs
...ican Society for Clinical Investigation. In cell
cultures that express large quantities of Pgp, the VUMCresearchers found that protease inhibitors were not readily absorbed by thecells. In the body, Pgp is present in the intestines, where it preventsabsorption, and in the kidneys and liver,...
Oregon Health Sciences University Researcher Presents Results Of Clinical Trials Of Possible Stroke-Fighting Drug
...se of reducing stroke-related injury by stablizing cell
membranes longenough to prevent large-scale brain cell
damage after stroke. The clinical trial, involving nearly 400 patients in 33 centers nationwide,sh...
"Powerful New Tool" For AIDS Is Reported In Science
...ired instrumentation. Initial in vivo results of T cell
proliferation rates in AIDS patients using isotope...ake new cells was in fact the key determinant of T cell
counts and the patients' responses to protease inhibitor therapy in AIDS. T cells were indeed being...
Snipping Inflammation In The Bud; New Agents May Provide Relief
... infection or injury. Itbegins at the level of the cell
when, in response to an injury or irritation,white...mselves to aL-selectin proteins and preventing the cell
from linking with an opposing cell. But synthetic molecules that only inhibit cells from linking up ...
Declining National Rates Of HIV-Related Deaths And Illnesses Due To Combination Antiretroviral Therapy With Protease Inhibitors
...ge, ethnicity andmode of HIV acquisition), and CD4 cell
count (a measure of drugs' efficacy) atfirst study visit, as well as method of payment (i.e., private insurance,Medicare/Medicaid, self-pay and Ryan White Care Act prescription programs). Death rates and protease inhibitor prescription rateswere then...
Researchers Identify Candidate Immunosuppressant With Fewer Side Effects
...le in the pathway thattransmits signals from the T cell
receptor to the nucleus. The key differencebetween...ne response. The pivotal role of NFAT in T cell
activation and immunosuppressionmakes it an active area of current research. Two groups of Harvard i...
Chemical Society's Highest Award Goes To Ronald Breslow
... differentiate. "Theyjust go around and around the cell
cycle, and keep multiplying," explainedBreslow. His chemotherapy candidates turn on the chemical signal that directsthe cells' DNA toward differentiation instead of reproduction. Once the cancercells differentiate, they become normal adults. ...
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