Tag: "cellular" at medical news

AIDS Treatments Seek To Eradicate Virus, Restore Immunity

...during theircombination drug therapy, according to cellular immunologist Kent Weinhold. Cytotoxic lymph cells (CTLs), also known as killer T-cells, are immune systemcells that attempt to attack HIV when it invades the body, but the virusoverwhelms this immune response. Weinhold will extract these T-c...

Discovery Hints At Multitude Of New Targets For Drugs

...ones act on steroid hormone receptors that trigger cellular responses. The new view holds that steroi...n the cell'snucleus, activating genes that produce cellular responses. When a hormoneor drug plugs into a receptor, that action changes the shape, or conformat...

Fertilization Protein Structure To AID in Leukemia Treatment

...rogram director in NSF's division of molecular and cellular biosciences, which funded Stout's research. The Scripps researchers hope that drugs targeted toward the cavity in CD38 could be used to alter signal transmission and allow the immune system to eliminate leukemia cells....

Radon, Especially In Combination With Smoking, Contributes To Lung Cancer Deaths

... Data should become stronger as molecular and cellular evidence accumulates, as the health of miners continues to be monitored, and as studies are done to measure directly the effects of radon exposure in the general population. The study was funded by the Environmental Protection Agency. T...

Snipping Inflammation In The Bud; New Agents May Provide Relief

...ynthetic molecules,for example, can slip off their cellular targets and the L-selectin proteins cancome back into play. However, the new class of agents developed by Kiessling and colleagues Eva J.Gordon and William J. Sanders, dubbed "neoglycopolymers," also cause cells toshed the surface protein L-selecti...

Combined Therapy Improved Care Of Patients With Type 2 Diabetes Proper Use Of New Oral Medications Evaluated

...Ph.D.,professor of medicine (endocrinology) and of cellular and molecular physiologyat Yale and an investigator with the Howard Hughes Medical Institute. "Thecombined therapy was logical and reversed two abnormalities that patients withthis disorder experience. Metformin acted primarily to decrease the pati...

Scientists To Prepare Advisory Report On What's Been Learned About The Possible Adverse Health Effects of Electric Fields

...sosupported studies of how EMF affects animals and cellular systems -- effectsthat might be too subtle to show up in real- world epidemiological studies ofexposed groups. Beginning with about $4 million from the federal government anda matching $4 million from industry, total research costs under this effort...

Intervention can help reduce risky sexual behavior, according to results published in Science

...cine; the interplay between HIV proteinsand normal cellular activities; and the virus's wily strategies for evading theimmune system. In addition, there are commentaries on a variety of topics,including: the challenge of testing HIV patients for resistance to AIDS drugs; aproposal to create a national tissue ...

OHSU Scientists Begin Human Trials Of A Drug Aimed At The Underlying Cause Of Chronic Myelogenous Leukemia

... behave in an abnormal waybecause the structure of cellular proteins has been altered by mutations. Although this new agent needs to be validated in large numbers of patients, Dr.Druker's work is the perfect example of the power of molecular biology to bringnew, more effective and potentially less toxic treat...

Novel Therapy To Treat Lung Cancer Patients Enrolling Patients At UCSF Cancer Center

...ownthe material between cells to make room for new cellular growth. There is good reason for enthusiasm about this drug because the preliminarydata looks favorable and suggests that MMPs inhibitors (MMPIs) are effective inslowing tumor growth, said David Jablons, MD, UCSF assistant professor ofsurgery and p...

University Of Pittsburgh Chosen By NCI As One Of Three Pioneer Sites ForBiocombinatorial Chemistry Research

... in specific assays to learn whetherthey interrupt cellular activities that can lead to cancer. Pittsburghresearchers also will create a repository for newly manufactured compounds thatthen can be acquired and tested by outside investigators. "The University of Pittsburgh is at the academic forefron...

Microwaves May Provide Early Detection Of Breast Cancer

...ss than one one-hundredth of thepower of a typical cellular phone," Bridges said. "Further, the duration ofmic.... MelvinGriem, professor emeritus of radiation and cellular oncology at the Universityof Chicago....

Scientists Discover How Aspirin Reduces Inflammation

... of the initiators in this inflammatory cascade, a cellular proteincalled NF-kB, is inactive until it gets int... "This work suggests that one of the critical cellular proteins thataspirin targets to inhibit inflammation is a kinase that activates the NF-kBpathway. Si...

Maternal Tissue Typing Could Improve Selection Of Kidney Transplant Donors

...tutes of Health (NIH) have discovered that cellular markers, or human leukocyte antigens (HLA), on maternal tissue can provide valuable information for identifying the most suitable donors for individuals in need of kidney transplants. The new finding was reported Dec. 3, 1998, ...

Study Offers Hope For Immune Reconstitution After HIV Infection

...39ve to memoryphenotype, presumably as a result of cellular proliferation accompanying thisprocess." The researchers also found that TREC quantity declines significantly with age. Still, they detected TREC-containing T cells in blood samples from persons asold as 73 years. Elderly persons with intact thymus ...

Fred Hutchinson Cancer Research Center And Targeted Genetics Corp. Publish Data On Adoptive Immunotherapy For HIV

...rporation and forms thefoundation of the company's cellular therapy platform. "Adoptive immunotherapy represen... diseasesas well as an extensive gene delivery and cellular therapy technology platform. The study was funded by the National Institute of Allergy and Infectio...

Cancer Added To Hangover Headaches

...ined from alcohol consumption. "This indicates the cellular nucleotide pool and DNA are exposed constantly toacetaldehyde even without drinking alcoholic beverages," says Shibutani. Scientists at Kyoto University in Japan and at the Fox Chase Cancer Center inPhiladelphia also contributed to the Biochemistry p...

Young Patients Get State-Of-The-Art "TLC" In Cedars-Sinai Medical Center's New Pediatric Emergency Facility

...rhead "pages" or announcements, thanks to aspecial cellular telephone system for physicians. "We tried to develop an environment that would insulate children from the commonexperiences they might encounter in emergency centers that treat both childrenand adults," explained Joel Geiderman, M.D., FACEP, co-chai...

Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science

...d sugar, orglucose, into their cells. This lack of cellular "fuel" and the high levels ofglucose in the blood stream cause weight loss, fatigue, and a variety oflong-term complications. To store and use glucose, cells need assistance from the hormone insulin, whichcontrols a complex series of steps to remove...

Novel Biological Interaction Found To Explain Blood Vessel Growth To Tumors

...y looked for where angiostatin's "key" fit intothe cellular "lock" that then shut down vessel growth. Since plasminogen is known to bind to a protein called annexin II on endothelialcells, they expected to find that angiostatin bound to same site.After several years of gathering material and analyzing data, ...

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