Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...ach is full -- a discovery that could leadto a new class of drugs that bypass the leptin brain circuit and ... BiologicalChemistry. "Our results suggest that a class of drugs called B3 adrenergic receptoragonists might help in weight loss," said Collins, a Duke phar...Discovery Hints At Multitude Of New Targets For Drugs
... However, surprisingly, they discovered a new class of compounds that behaveddifferently from either o...onists in others. Discovery of this third class has broad clinical implications, said DonaldMcDonnell, an associate professor of pharmacology in the...New Drug For Parkinson's Disease Proves Effective, Study Finds
... the first of the nextgeneration of an established class of anti-Parkinson's drugs tobe launched," says the study's medical director, Karl Kieburtz, M.D., associate professor of neurology at Rochester's School of Medicine and Dentistry. "It appears to bemore powerful and to be better tolerated by patients ...NIH Honors Emory Researcher With Merit Award For Work On Renin-Angiotensin System
...ethis pathway, the AT1 receptor is a member of the class of receptors called"seven transmembrane receptors,...eviously unknown signaling pathways for the entire class ofreceptors, which include those for a variety of critical bodily functions. ACE in Reproductive Bio...Affordable, Hand-Held Biosensor For Diagnostics
...em, to small amounts of their specific antigens--a class of moleculesproduced by invading organisms that include viruses, bacteria, in addition totoxins and allergens. The biosensor was able to detect DNA concentrations at levels of down to9 femtograms per square millimeter. (A femtogram is a milli...MIT Solution To Math Problem Could Lead To Better Dental Implants, More Resistance To Missiles
...elop a mathematical theory todescribe a ubiquitous class of materials. They are now using that theory tocreate new materials with exceptional properties. The work has also led to amore efficient way of testing the quality of components made of these materials. Professor Subra Suresh (right) shows a protot......ritain. The center, given to Yale by Paul Mellon, class of 1929, holdsresources which illustrate British life and culture from the 16th century to thepresent.......nd sold under the brand namePaxil. It is one of a class of anti-depressant drugs known as selectiveserotonin re-uptake inhibitors, or SSRIs, which have been in clinical use for adecade. SSRIs are believed to relieve symptoms of depression by increasing theavailability of serotonin required to transmit el......dividuals taking enalapril, which is a member of a class of drugs calledACE-inhibitors. The study provides more evidence that calcium antagonists (preferred term forcalcium channel blockers) may pose risks for certain people, including thosewith diabetes and coronary heart disease. Past studies of short-...Snipping Inflammation In The Bud; New Agents May Provide Relief
...ocess of inflammation,scientists have forged a new class of synthetic molecules that offer a newstrategy fo...roteins cancome back into play. However, the new class of agents developed by Kiessling and colleagues Eva J.Gordon and William J. Sanders, dubbed "neoglyc......ance P and neurokinin A, twomembers of a different class of neurotransmitters called the tachykinins. By measuring how long it took mice to move away from applied mechanicalpressure, or how many seconds they licked skin where hot pepper extract had beenapplied, Cao determined that the knockout mic...- Novel class of highly lipophilic camptothecins, known as Karenitecins,demonstrates potent oral antitumor activity, acceptable safety and appear to beinsensitive to common tumor-associated drug resistance mechanisms - BioNumerik's novel chemoprotecting age...Clinical Pharmacists Improve Outcomes Of Heart Failure Patients
... likely to be on a higherdose of ACE-inhibitors, a class of drugs which is very important in reducingfuture events and deaths for heart failure patients, Gattis said. "Clinical pharmacists have been extremely helpful -- both for physiciansand patients -- in evaluating the side effects of drugs and ...Researchers Synthesize Compounds For New Class Of Antibiotics
...open thedoor to the development of an entirely new class of antibiotics for use againsttoday's increasingly drug-resistant bacteria as well as emerging forms ofbacteria. In a recent issue of the Journal of Organic Chemistry, the research teamreported that they have chemically synthesized myxopyroni...Compound In Meat Prevents Diabetes, Study Suggests
...searchers say CLA appears to work as well as a new class of diabetes-fighting drugs, the thiazolidinediones, or TZDs. Martha Belury, Purdue assistant professor of foods and nutrition, says: "If you inherit a genetic predisposition to adult-onset diabetes and you're obese and inactive, then you may well dev...New Drug Prevents Breast Cancer In Postmenopausal Women, UCSF Researchers Report
...d to placebo. Raloxifene and tamoxifen belong to a class of drugs called selective estrogenreceptor modulators (SERMS), which block the actions of estrogen in sometissues, such as the breasts, and mimic estrogen in other tissues, such as thebones. "During the clinical trials of raloxifene, we saw twice as...Polish Dumpling-Like Particle Has Potential In Drug Delivery
...ery. Knedels are variations and improvements on a class of polymers -- chain-like structures of repeating compound assemblies -- called micelles. There has been lots of interest this decade in micelles for drug delivery, but they have a major drawback for this purpose. They are dynamic and unstable. If...American Heart Association Comment: Tirofiban -- The Platelet Receptor Blocker For Heart Attack
...enting on two studies. Tirofiban is a member of a class of drugs called "platelet glycoprotein receptorblockers." As the name suggests, the drug blocks the action of platelets,cells that clump to help form a blood clot. The drugs have been used to improve the results of angioplasty -- a bloodvessel-ope...Metrifonate, A New Alzheimer Drug, Helps Behavior Problems
...ation from Bayer. Metrifonate belongs to a class of drugs called acetylcholinesterase(AChE) inhibit...s. "This metrifonate study shows that this class of drugs can benefitpatients with mild or moderate Alzheimer's disease, at least temporarily. Thisme......iophysica Acta . Etoposide is a member of a small class of drugs known as topoisomerase-IIinhibitors. These drugs work by blocking the action of an enzyme found incells known as topoisomerase II (topo II). The job of topo II is to untangleDNA strands during cell division; failure to do so is lethal to the...