Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...ll -- a discovery that could leadto a new class of drugs that bypass the leptin brain circuit and target th...alChemistry. "Our results suggest that a class of drugs called B3 adrenergic receptoragonists might help in weight loss," said Collins, a Duke pharmacologis...AIDS Treatments Seek To Eradicate Virus, Restore Immunity
...atientswill receive a potent mixture of anti-viral drugs that includes AZT, 3TC,and ritonavir. AZT and 3TC ...erent from other anti-viral compounds. The three drugs are expected to reduce the "viral load" or theamount of HIV in patients' bodies, by 99 percent, said...DNA Imaging to Design Better Drugs
Designing drugs and knowing exactly how they work may have justgot...ntages of the new assay is it shows researchershow drugs affect single DNA molecules, said Dr. Lawrence Bottomley, aGeorgia Tech chemistry professor who spec...New Colorectal Cancer Treatment Available
...n or rectal cancer usually involves the use of the drugs 5-fluorouracil (5FU) and leucovorin (LV). "Unfortunately many patients don't respond to these drugs, and most patients ultimately progress through their first line therapy. Until now, we have had no effective second line therapy to offer these patie...Discovery Hints At Multitude Of New Targets For Drugs
DURHAM, N.C. -- A new study of how drugs plug into the human progesteronereceptor in the cell supports a new and different view of how drugs andhormones act on steroid hormone receptors that trigger cellular responses. The new view ...Alzheimer's disease center seeks patients for new drug studies
...r's Disease Center. "We are hopeful that these new drugs will prove beneficial to at least some of the patients who experience the devastating symptoms of Alzheimer's." Svetlik said the clinic also has several other drug trials under way. Only one Alzheimer's medication, Cognex, has received approval from...What Makes Tics Tick? Clues Found In Tourette Twins' Caudates
...rred by the fact that Tourette symptoms respond to drugs like haloperidol that block D2 dopamine receptors. They used a radioactive tracer drug, IBZM (iodobenzamide), that similarly blocks D2 receptors, and a SPECT* (single-photon emission computed tomography) scanner to image dopamine binding in five ide...Scientists Produce New Anti-Malarial Compound
... aremuch less expensive and easier to produce than drugs presentlyavailable. When tested in laboratory cultures of infected blood, theexperimental drugs killed Plasmodium falciparum, the species ofmosquito-borne parasite that causes most malaria deaths ...Study Shows Major Savings In Supervising TB Care
... is more convenient because patients take multiple drugs at the same time in a single capsule. This treatment was more effective and less expensive than conventional individual drug therapy, which was the least effective and most expensive form of therapy, according to the study. Overall, the average cos...Fertilization Protein Structure To AID in Leukemia Treatment
...esearch. The Scripps researchers hope that drugs targeted toward the cavity in CD38 could be used to alter signal transmission and allow the immune system to eliminate leukemia cells....Benefits Of New Diet Drug Don't Outweigh Risks
...ntly patients were prescribed appetite suppressing drugs such as Redux for no longer than 12 weeks to help ...they have largely agreed that for weight reduction drugs to be effective, people must take them chronically, perhaps for a lifetime. To determine just how m...NIAID Stops AIDS Study Prematurely Because Drug 'Cocktail' Boosts Survival
...3TC, Eron said. Among patients receiving those two drugs and indinavir, they found only 33 such events. "There were 18 deaths in the double-therapy arm of the study vs. eight deaths in the triple- therapy arm," he said. "No major differences were found in either safety or toxicity between the two treatme...ACTG Protocol 185 Enrollment Halted
... information on long-term safety of antiretroviral drugs in pregnancy is lacking. Long-term follow-up is recommended for all infants exposed to antiretroviral treatments in utero or as newborns, and is being provided for infants born in Pediatric ACTG perinatal clinical trials through other protocols in t...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...archers can elicit biological effects by designing drugs to link upwith proteins just as natural ligands do. But in the process the drugs blockthe natural action of the protein. Toone said a "holy grail" of pharmaceutical chemistry ...UNC-CH Study Shows State Protects HMO Clients Poorly
...rmation about financial risk-sharing arrangements, drugs that will be paid for, treatment of specific conditions, coverage of experimental or investigational procedures or clinical criteria used to review the need for certain treatments or services. “This information is especially useful for individ...Researchers Gain Insights Into Drugs Used For Manic-Depression
... Academy of Sciences, thescientists show that both drugs stimulate release of a chemical thattriggers brain...moodswings of bipolar disorder. Used together, the drugs may achieve a desiredoutcome without causing dangerous side effects. Some three million Ame...Substance from Grapefruit Juice May Make Medications Safer
...d oral medications, researchers have found. These drugs include nearly all calcium channel blockers (used ...n everyone. What should people who regularly take drugs that are metabolized by CYP3A4 do? "Consistency is the key," Dr. Lown says. "If you regularly drin......d tell their children about the harmful effects of drugs and alcohol. "People's concerns with teenage health issues and sex have become hopelessly jumbled," she says. "We can accept direct messages of no-alcohol and no-drug use. But when it comes to sex we rely on hidden messages. We believe that if we tal...New Drug For Parkinson's Disease Proves Effective, Study Finds
...ctive and may cause fewer side effects thansimilar drugs currently on the market. Patients treated withpram...ration of an established class of anti-Parkinson's drugs tobe launched," says the study's medical director, Karl Kieburtz, M.D., associate professor of neuro...... molecular pump called P-glycoprotein that flushes drugs out ofcells. The study, conducted by Associate Pro...press production of the pump longenough for cancer drugs to work. Therapies for cancer treatment often use chemicals that impair the geneticmachinery of cel...