Study shows promise in identifying kidney failure
... and colleagues found evidence confirming the NGAL gene and protein are directly correlated to kidney failure. The gene and its biomarkers were present in higher concentrations during acute renal injury, he said. These s...UCSF study offers insight into human circadian rhythms
Scientists have identified a gene and mutation within it that causes a rare sleep be...et lag or nighttime work shifts. More broadly, the gene provides a probe for exploring the regulatory mechanisms of the body's internal biological clock, or...African-American women with endometrial cancer have more aggressive cancer than Caucasian women
...s subsequently performed a study evaluating global gene expression among patients with advanced endometria... was found that distinct and different patterns of gene expression may characterize advanced endometrial cancers in African-American and Caucasian women, an...Targeting mutant B-Raf protein reduces melanoma development
...identified the mechanism by which the most mutated gene in melanoma, called v599EB-Raf, aids melanoma tumo...vious studies have shown B-Raf is the most mutated gene in melanomas, present in about 60 percent of human melanomas, but the role mutant B-Raf plays in cau...Diagnostic test for range of blood disorders on the horizon
... Research, UK) and colleagues analysed a candidate gene called JAK2 in 140 patients with myeloproliferativ...A single point mutation was identified in the JAK2 gene in 71 (97%) of 73 patients with polycythaemia vera, 29 (57%) of 51 with essential thrombocythaemia, ...Genes for alcohol consumption identified
...eir drinking habits. The research focused on a key gene that controls chemical signalling in the brain. Different versions of this gene may affect the balance and effect of signalling molecules and in turn help to shape individual drink...Aspirin's potential ability to prevent colon polyps may not apply equally to all
...more strongly in women with alternative forms of a gene involved in the metabolism of aspirin than in thos...e paper's lead author. "We decided to look at the gene for an enzyme that metabolizes aspirin and is known to have variant forms that slow down that proces...Compound may help prevent diabetes in fast-food fans
...netic level. They found significant differences in gene expression, as measured by messenger RNA changes, between animals that became insulin resistant and those that did not, they say. Although the exact mechanism by which HPMC works is unclear, Yokoyama believes that it acts as a fat regulator. The comp...Mayo Clinic discovers 'new pathway' against pancreatic cancer
...val and growth through its effects on a well-known gene regulator called NF Kappa B (pronounced "en-ef-kappa-bee"). The NF Kappa B protein is well known to researchers as a transcription factor that regulates many genes. In cancer cells, NF Kappa B regulates genes involved in cancer cell survival, prolif...Neuronal death and processing of Tau protein in Alzheimer's disease
...omosome 17 (FTDP-17), several mutations in the tau gene were identified showing that primary malfunction of tau can lead to neurodegeneration. Such findings shed new light on the role of post-translational modifications of tau protein occurring in other tauopathies (such as AD), including aberrant proteol...Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
...lations that led to the discovery of BRCA-1 and -2 gene mutations, prompting many scientists to speculate that there may also be a genetic component contributing to breast cancer in African Americans. Alero Fregene, M.D. and Lisa A. Newman, M.D., M.P.H. of the University of Michigan Comprehensive Cancer ...HIV-1 spread through six transmission lines in the UK
...history of the HIV-1 subtype B strain from sampled gene sequence data. Molecular data on HIV-1 has become ... available since the introduction of routine HIV-1 gene sequencing for drug resistance. Scientists used this data to follow the changing number of infected ...CAS science spotlight identifies most requested article
...in such diverse fields as catalysis, pharmacology, gene therapy, and materials science. The authors, editors and publisher associated with the most requested article were recognized during the CAS Science Spotlight ceremony. Those honored along with the co-authors were Prof. John Caldwell and Prof. Nina ...Philanthropist Paul F. Glenn launches labs for aging research at Harvard Medical School
...ience, Sinclair's group found that a key longevity gene called SIRT1 is switched on in rats that are subjected to calorie restriction, which then increased the lifespan of the rat's cells. In an interesting twist, the research team used the blood of these long-lived rats to grow human cells in the cultur...Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
In a major breakthrough in cancer gene therapy, a Northwestern University researcher has ...t has been associated with earlier forms of cancer gene therapy. Chung Lee, John T. Grayhack, M.D., Professor of Urology at Northwestern University Feinber...Gene for age-related macular degeneration discovered by Yale researchers
...chers at Yale School of Medicine have identified a gene for age-related macular degeneration (AMD) on a re...ly interdisciplinary approach to conclude that the gene for a substance known as complement factor H (CFH) on chromosome 1 is associated with AMD. "This i...2005 Award for Basic Research in Biological Mineralization
...nvestigating the molecular basis of tooth-specific gene regulation. In 2001, Dr. MacDougall received the IADR Distinguished Scientist Pulp Biology Research Award, and in 2003, the National AADR Student Research Group Mentor of the Year Award. In 2000, Dr. MacDougall initiated the outreach program called ...2005 Pulp Biology Research Award
...vitro. More recently, he has described profiles of gene expression in odontoblasts using two original culture systems from pulp tissue and thick slices of human teeth. These in vitro studies allowed him to show the role of TGFβ during dentin repair and, particularly, the target molecules such as a ...Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
... the investigators analysed the functionality of a gene responsible for DNA repair, the so called MGMT gene - the improvement is even more dramatic, as almost half of those patients whose tumours carry an ina...Decreased levels of 'good' cholesterol in children with Progeria may cause premature heart disease
...mission when the Foundation helped to discover the gene that causes Progeria. For more information about Progeria or PRF, visit www.ProgeriaResearch.org ....