Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
...nical trial testing of this new treatment plan was halted early, the researchers report in the Journal of Clinical Oncology . "This is a far better result than we had anticipated and seems to suggest that simultaneous use of chemotherapy and Herceptin offers a much more potent treatment than use of these d...Promising treatments for Huntington's disease identified in UCI study
...rial drug therapies developed from these compounds halted the brain-cell damage caused by the fatal, progressive neurodegenerative disorder. Such types of therapies have proven very effective in the treatment of other complex human diseases, like cancers and AIDS. And while any human benefits from this stud...New way to block pox shows promise in lab study
Acute viral infections, including smallpox, may be halted by aiming a drug not at the virus but at the cellular machinery it needs to spread from cell to cell--an approach that might eliminate the problem of antiviral drug resistance, report researchers supported by the National Institute of Allergy and Inf...Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy
...normal signals triggering cell death that had been halted by the melanoma cells. Both of these methods reduc...ng siRNA or reintroducing the missing PTEN protein halted tumor progression. "Identifying Akt3 as a possible target to halt the growth of and kill melanoma c...M. D. Anderson researchers discover key protein in psoriasis
...ting genes. The STAT3-blocking agent significantly halted the progress of the lesions and reversed symptoms such as slowing cell growth, shrinking dilated blood capillaries and reducing inflammation. "This study opens the door to a whole new kind of therapy for psoriasis," said DiGiovanni. "This is a brand ...Ongoing transfusions needed to avoid strokes in children with sickle cell disease
...14 sites in the United States and Canada, also was halted early in September 1997 by the NHLBI because of th...t was clear within a few months. Some of those who halted transfusions restarted for other reasons such as pain," Dr. Adams says of the still poorly understoo...Chemoprevention backgrounder: Working for a future of cancer chemoprevention
... against recurrence of large polyps, have not been halted although data is being intensely scrutinized by cardiovascular experts for similar problems to assure long-term patient safety. Aspirin, which also has the properties of a COX-2 inhibitor, has itself shown that it may help prevent colon cancer. A stu...New medication dramatically decreases congestive heart failure in African-American patients
.... The results were so favorable that investigators halted the multi-center trial so that all the 1,050 study participants suffering from advanced heart failure, including those on a placebo, could be given the combined drug treatment, said Dr. Clyde Yancy, a study author and director of the Congestive Heart...Two novel agents work synergistically to treat lung cancer in animal experiment
...s were disappointing - enrollment to the trial was halted earlier this year when SCH66336, used by itself, showed no benefit during an interim analysis of results. The researchers chose to test IGFBP-3 because IGFBP-3 has the ability to regulate the amount of IGF, a growth factor that is associated wit...'Energy blocker' kills big tumors in rats
...eating rat liver cancer cells with 3-bromopyruvate halted the cells production of ATP within 30 minutes, and visual evidence of the cells' self-destruction was apparent almost immediately. Four times as much of the compound was necessary to begin decreasing ATP production in normal liver cells. Turnin...VELCADE(TM) data confirms long-term survival
...ncology (ASCO) in New Orleans, USA. The trial was halted one year early after an independent data monitoring committee concluded the findings of a pre-specified interim analysis showed a statistically significant improvement in time-to-disease progression in favour of VELCADE TM . The APEX trial enrolled 6...Duke scientists identify new way to block blood vessels that feed cancer growth
...he source of all the signals, we have successfully halted the cancerous blood vessel growth in animals without harming normal blood vessels." Approximately half of all cancer patients in the U.S. are treated with radiation therapy. However, the success of therapy depends largely on how sensitive a tumor's b...Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research
...xperimental adenovirus-based therapy that abruptly halted gene therapy research nationwide in 1999, when 18-year-old patient Jesse Gelsinger died while participating in a University of Pennsylvania clinical trial. The study wasn't about cancer, but was designed to treat a rare metabolic disorder. Another ex...WHI study finds no heart disease benefit, increased stroke risk with estrogen alone
...s-progestin trial, was also stopped early. It was halted in July 2002 after 5.6 years of followup because of an increased risk of breast cancer and because the increased risks of breast cancer, coronary heart disease, stroke, and blood clots outweighed the benefits of a reduced risk of hip fracture and col...Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
... women. The WHI estrogen plus progestin trial was halted in July 2002 because health risks exceeded benefits, including increased risks for CHD, stroke and breast cancer. In this new report on the estrogen alone intervention, the WHI investigators assessed the effects of CEE, the most commonly used postmen...New animal model for Alzheimer vaccine
...to discover the cause of serious side effects that halted an earlier study of the vaccine in people, according to the Alzheimer's Association. "The animal model described in this study expands the way we might evaluate new vaccine products," said William Thies, Ph.D., Alzheimer's Association vice president ...Vaccine nips breast cancer in the bud
...sion in parallel revealed that the immune reaction halted carcinogenesis and reverted neoplastic lesions to an early stage. This study highlights the potential of a combinatorial approach to vaccination for the prevention and suppression of neoplastic lesions....Significant disparities still exist in screening mammography rates; minorities underestimated
... parity, outreach efforts and interventions may be halted or downsized, when these efforts are still very much needed. Her study did find several methods that seem to be effective at increasing the rates of mammography screening. Outreach efforts that target individuals directly in health care settings wer...Drop in hormone therapy use shows physicians heed clinical trial findings, Stanford researchers say
...ealing with the estrogen/progestin combination was halted early when researchers for the federally funded Wo...cker and a diuretic. The alpha-blocker portion was halted early when researchers found that those taking the medication had a higher rate of heart failure. ...New treatment improves long-term outlook for breast cancer survivors
...d Journal of Medicine. The clinical trial has been halted early because of the positive results and researchers are notifying the 5,187 women worldwide who have participated in the study. Women on letrozole will continue taking the drug and those on the placebo can begin taking letrozole, if they wish. "Th...