Vaccine may complement conventional treatment for chronic leukaemia
... CML can be treated with a drug called imatinib or interferon alfa. Treatment with imatinib can lead to complete...sease at a molecular level. Of the six patients on interferon alfa, five showed a reduction of their stable disease during vaccinations, with two reaching complet...Researchers discover genetic variant that may explain why women develop M.S. more than men
.... "If you have a gene that produces high levels of interferon gamma, it may predispose you to developing MS. Und...ene variant that is related to higher secretion of interferon gamma." To researchers looking for a cure for MS -- where currently there is none -- the finding is ...Genes in the interferon system important in SLE
...e some 200 genes that are seen as belonging to the interferon system, we were able to identify two genes with su...irtually the only researchers who claimed that the interferon system, which is involved in the body's defense against viruses, etc., was also behind the autoimmun...No advantage of combination drug therapy for chronic hepatitis B Infection
... week's issue of THE LANCET suggest that pegylated interferon alpha offers the best treatment option for people ...has suggested that treatment either with standard interferon or nucleoside analogues is only around 20% effective at best. Harry Janssen (Erasmus University Med...Engineered stem cells can home in on tumors and deliver drug payload in mice
...dy, they looked at whether MSC engineered to carry interferon beta could treat mice that were implanted with hum...e team tested whether MSC engineered to express an interferon beta gene could provide a sustained and targeted effect directly to cancer cells. For each o...Studies demonstrate positive data in treatment of hepatitis C
...dard treatment for hepatitis C is a combination of interferon alfa and ribavirin, which act as anti-viral agents...lear the virus. Combination therapy with pegylated interferon plus ribavirin for 24 to 48 weeks can result in eradication of the virus in about 50 percent of pati...Drug combination shows promise in treating hepatitis C
...Pegasys is the most recent form of pegylated alpha interferon approved by the Food and Drug Administration (2002). Di Bisceglie helped design the study and evaluate the preliminary results. Di Bisceglie will present his findings at the 55th annual meeting of the American Association for the Study of Liver Dis...Study shows weight-based REBETOL dosing in combination with PEG-INTRON significantly improves ...
...epatitis C in patients not previously treated with interferon alpha who have compensated liver disease and are at least 18 years of age. The recommended dose in the United States of this combination therapy is PEG-INTRON 1.5 mcg/kg/week by subcutaneous injection and REBETOL 800 mg/day taken orally for 48 weeks...Scientists identify key mechanism in estrogen's role in preventing bone loss
...to the expression of the immune regulatory protein interferon gamma (IFN-g), which in turn stimulates a protein called class II transactivator (CIITA). They found that increased expression of CIITA leads to expanded antigen presentation by macrophages (immune cells that alert T cells to the presence of invadin...Further evidence showing treatment benefits of beta interferon for MS
...f multiple sclerosis given a weekly injection with interferon beta are less likely to progress to full clinical ...2001; 357: 1576-82) showed encouraging results for interferon beta in delaying the progression of full clinical symptoms of multiple sclerosis compared with place...Researchers develop better understanding of tamoxifen resistance in breast cancer patients
...lication of our work is that by adding the protein interferon to antiestrogen therapy, we should be able to turn... preclinical studies to test the effects of adding interferon to tamoxifen treatment. "Used as a primary treatment, interferon can be extremely toxic, so we will...Breakthrough therapies treat Crohn's disease
...ts. A humanized antibody aimed at a novel target, interferon gamma, has shown excellent tolerability and activity in this patient population. Researchers compared the results of one or two intravenous doses of fontolizumab in patients with moderate to severe CD. A total of 133 patients with CDAI scores betw...International hepatitis C study examines new approaches to treatment
...de patients a proven option with another pegylated interferon if Peg-Intron combination therapy failed to work for them." The REPEAT Trial is an international study enrolling approximately 888 patients at 98 centers in 14 countries worldwide. Approximately 330 patients will be enrolled at the 33 partic...How cancer neutralizes T cell attack
...s: a reduction of the release of a molecule called interferon gamma, which enhances the stimulation of the immune system; and a reduction in the expression of a protein called perforin, which is essential for cell destruction. "The important thing for us is that the tumor effects seem to be reversible," says D...Northwestern Memorial launches trial to determine most effective treatment for hepatitis C
...e two commercially available regimens of pegylated interferon alpha therapy plus ribavirin for chronic hepatitis... hepatitis C virus is the combination of pegylated interferon alpha and ribavirin. Pegylated interferon alpha is an antiviral drug used to boost the immune system...Existing therapies applied to new use in broader spectrum of cancer care
...amatically reduces tumor size. In combination with interferon treatment, which encourages further elevation of Vitamin B12 receptor levels in tumor cells, nitrosylcobalamin leads to complete tumor regression in mice. "In principle, this targeted therapeutic will be effective in human tumors," Lindner s...Powerful stem cells harnessed to search for cancer metastasis
...man ovarian cancer. So far, researchers delivered interferon alpha and beta, and an oncolytic (tumor-destroying) virus into the tumors. "This drug delivery system is attracted to cancers, both primary and metastatic, and anti-tumor effects are observed when the cells integrate into the tumor microenviron...Tip sheet for the February 24, 2004 Neurology
...ion or death. Patient Page and study examine interferon treatment in multiple sclerosis (MS) The monthly ...iscusses the risks of liver abnormalities while on interferon therapy for MS. -interferon drugs are injected to help reduce the frequency of attacks. A study led ...Study findings offer new hope for the estimated 300,000 Americans infected with HIV and Hepatitis C
...revious generation of hepatitis C therapy standard interferon and ribavirin. Efficacy was measured as the susta...howed superior efficacy to treatment with standard interferon and ribavirin (20 percent vs. 12 percent), which is important for patients who cannot tolerate ribav...Promising drug fails to thwart fatal lung disease in large trial
...s of the trial did suggest that the drug, known as interferon gamma-1b, might extend the lives of select patient...iversity Medical Center. "The bottom-line is that interferon gamma does not appear to be effective in slowing progression of pulmonary fibrosis (PF), but could p...