Tag: "mice" at medical news
New study in 'Nature' demonstrates protection against cell death during heart attack
...s discovered that blocking a particular protein in mice
protects the heart from injury due to loss of blood flow during a heart attack. Moreover, drugs already exist that block this protein cyclophilin D but they have never been used in actual patient care, partially because data didn't exist until now...
UCSF study offers insight into human circadian rhythms
... of circadian rhythms. As expected, the transgenic mice
displayed the same abnormal sleeping pattern seen in the human cases of FASPS, as measured in the decrease in their wheel-running activity. Unexpectedly, however, the result was the opposite in the transgenic flies, as displayed by its extended locom...
Mouse model reveals potential way to reduce cardiac deaths in kidney patients
...of Medicine in St. Louis. "The drug we used in the mice
and other similar agents can treat both the phosph... protein-7 (BMP-7) could prevent bone weakening in mice
whose kidneys had been damaged or removed. For the new study, researchers worked with a mouse model ...
OHSU scientists test medication to treat involuntary weight loss
...tabolism and appetite. Previous research involving mice
demonstrated that when this specific cell receptor... In this research, the scientists gave both normal mice
with a cachexia-like syndrome Neurocrine's orally-administered medication that blocks the M...
Novel therapy tested in mice could chase away cat allergies
... to cat allergen. The next step was to test GFD in mice
that we had made allergic to the allergenic protei...ed to have human cat-allergy cell receptors. These mice
were "passively allergic" to cats: they would react to cat protein only after the scientists first i...
First mouse model for multiple system atrophy points to new treatment targets for brain diseases
...ase Research, and colleagues demonstrated that the mice
showed symptoms similar to human MSA. These includ...d eventually nerve-cell malfunction and death. The mice
also showed slowly progressive problems with their motor skills associated with the nerve-cell damag...
Protein that helps skin cancer spread identified by Stanford researchers
... if left unchecked. But when the group treated the mice
with the collagen VII-blocking antibody, the skin cancer failed to spread, though the cancer remained. "This cancer isn't deadly unless it spreads," Khavari said. What's more, it appears that the antibody blocks only the cancer-spreading aspect of co...
Earlier use of prostate cancer vaccines urged by Hopkins scientists
...ored vaccines, say scientists testing the drugs in mice
at the Johns Hopkins Kimmel Cancer Center. "The w...ssue of Cancer Cell . In the Hopkins studies with mice
bred to develop prostate cancer, Drake and his collaborators at the University of Connecticut found ...
Ethical discussion should come before research
...ts at Stanford University are considering creating mice
with human brains. "When the barrier between humans and animals is broken down, could science unintentionally initiate the next pandemic?" said Jones. "We need to do these things in a thoughtful way, and not just consider the one experiment we're wo...
Philanthropist Paul F. Glenn launches labs for aging research at Harvard Medical School
...ed diet has been known to increase the lifespan of mice
and rats 40 percent by preventing them from gettin...alled PBEF in mammals. Experiments to test whether mice
that overproduce PBEF live longer, as his yeast cells did, are in progress. Mr. Glenn's interest in ...
Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
... specifically target metastatic prostate cancer in mice
without causing the toxic immune suppression that ... transplanted the tumor-specific immune cells into mice
that had been given a particularly aggressive form of prostate cancer, called TRAMP-C2. TRAMP-C2 pr...
News tips from the 2005, 54th Annual Scientific Sessions of the American College of Cardiology
...n Center.) Disrupted fat cell signaling in obese mice
has been linked to increased cell death, or apopto...e amount and function of the hormone leptin. Some mice
were leptin deficient, while others had nonworking leptin receptors. Made by fat cells, leptin regu...
Mouse gene shows new mechanism behind cardiac infarction in man
...SF4 gene was identified as the one responsible, as mice
with mutations in this gene displayed a lower degree of atherosclerosis, while mice
with more active variants of the gene displayed the opposite. Studies of two patient groups revealed...
Researchers close in on breast cancer vaccine
...ey injected the DNA vaccine under the skin of test mice
that had been engineered so that their immune syst...stem. The researchers loaded specific cells in the mice
with mammaglobin-A antigens and found that the vaccine-primed T-cells attacked those loaded cells. ...
Studies underscore genetic involvement in nicotine addiction & aggressive hostility
...author Jerry Stitzel, PhD, and his team found that mice
with the "threonine" polymorphism (an alteration t...d Chrna4 consumed significantly more nicotine than mice
with an alanine polymorphism in the same gene. The authors think that this threonine variation may ...
UCSD-Utah team develops mouse model to test therapies for macular degeneration
...MD and STGD, the UCSD-Utah investigators developed mice
with a mutant form of ELOVL4, which caused the mice
to develop significant lipofuscin accumulation and photoreceptor and RPE death in a pattern closely ...
Molecule important in cell construction also critical in learning and memory
...icine, and the senior author of the study, studied mice
missing one of these proteins---adducin--and found... the cytoskeleton developed normally. However, the mice
were impaired during fear conditioning and memory exercises. "We were hoping to find a mechanism tha...
Cellular porthole connects odors to brain
...exposed individual odor-detecting nerve cells from mice
to odor molecules. Unlike normal cells, those with...e. The researchers plan to study the behavior of mice
without NKCC1 and are now attempting to clone and characterize the chloride transporter to get a bet...
Protein that promotes survival of stem cells might be key to poor leukemia prognosis
...ience study, Opferman's team genetically modified mice
so that the gene for Mcl-1 could be specifically d...and progenitor cells. Upon genetic deletion, these mice
developed anemia and had severely reduced numbers of bone marrow (BM) cells, such as HSCs and progen...
Schepens scientists regenerate optic nerve for the first time
...in. This achievement, which occurred in laboratory mice
and is described in the March 1, 2005 issue of the.... But the regeneration happens only in the younger mice
whose brains had not yet formed a "glial scar." In the mice
that were slightly older and had develop...
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