DNA Imaging to Design Better Drugs
...ses anti-cancer drugs,bind to and alter DNA at the molecular level. This new method works by imaging individual DNA molecules. It'sfaster than traditional methods, and the results are direct andrelatively simple to interpret. "Our technique directly visualizes individual DNA molecules, whiletraditional techn...Discovery Hints At Multitude Of New Targets For Drugs
...erely on-off switches,but are far more complicated molecular "control panels" that couldbe manipulated by drugs...sity Medical Center departmentsof pharmacology and molecular cancer biology; Mansukh Wani, David Lee andC. Edgar Cook of the Research Triangle Institute (RTI), a...Scientists Produce New Anti-Malarial Compound
... and difficult-to-produce malaria drugworks at the molecular level. The new compounds use the samemechanism to ...idethe parasite by stealing electrons and breaking molecular bonds,making the drug toxic to the malaria parasite. "Our understanding of that mechanism has allowe...Fertilization Protein Structure To AID in Leukemia Treatment
...tion. The details of the events that occur at the molecular level when a sperm cell joins with an egg are ofte... is controlled by a regulatory molecule, a sort of molecular switch, termed a secondary messenger. The secondary messenger is synthesized inside the egg...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...vise computer programsthat predict sites where the molecular linkups will occur. "If you give the programs the protein's structure and the ligand'sstructure they will tell you where the ligand might bind," Toone added. But scientists' problem is they have not yet uncovered all of nature'stricks for...Mother's Milk: Nutrition And Nurture For Infants -- And The Best Defense Against Disease
...ay inhibit infection by binding topathogens at the molecular sites that they would otherwise use to attach to andthen attack cells in the infant. Another molecule with an antibacterial role islactoferrin, a protein that acts by binding iron in different situations. Insome circumstances, lactoferrin is also abl...New Approach To Multidrug Resistance
...of a prime protective mechanism usedby tumors -- a molecular pump called P-glycoprotein that flushes drugs out ofcells. The study, conducted by Associate Professor of Pharmacology andToxicology Joshua Hamilton at Dartmouth Medical School, with colleagues from themedical school and the Norris Cotton Cancer Cent...Common Drug-Capsule Coating Not As Inert As Previously Thought
...heth used a surface-force apparatus to measure the molecular forcesbetween two membranes supporting PEG and the...d. "We are now in a position to investigate at the molecular level themechanism behind the biocompatibility properties of this material. Andin learning about th...Targon And Duke Cancer Center Sign $3.75 Million Agreement To Produce Advanced Anti-Cancer Drugs
...r its groundbreaking research into the genetic and molecular basis of cancer and for developing innovative cancer vaccines and drugs. More than 6,000 cancer patients are admitted to Duke each year, and cancer patients make more than 100,000 visits to outpatient clinics each year. The center is one of six in th...Radon, Especially In Combination With Smoking, Contributes To Lung Cancer Deaths
...radon. Data should become stronger as molecular and cellular evidence accumulates, as the health of miners continues to be monitored, and as studies are done to measure directly the effects of radon exposure in the general population. The study was funded by the Environmental Protecti...Chemist Turns To Self-Assembly To Create New Drugs
Using metal atoms as molecular matchmakers, University ofRochester chemist Benjam... properties throughsuch an evolutionary process of molecular self-assembly."...Is Ritalin As Effective--And As Harmless--As It Could Be?
...lin) is a chiral drug, meaning that itcomes in two molecular forms, one a mirror image of the other (enantiomers).Currently Ritalin, which topped $350 million in sales last year, said Ding, isdistributed as a "racemic" mixture of both its chiral molecules -- d-threo andl-threo. However, some evidence ......or of medicine (endocrinology) and of cellular and molecular physiologyat Yale and an investigator with the Howard Hughes Medical Institute. "Thecombined therapy was logical and reversed two abnormalities that patients withthis disorder experience. Metformin acted primarily to decrease the patients'liver glu...New Research In Battling Alzheimer's Impact On Memory
...ompounds in mice with amyloid-ladenspleens. After molecular modeling simulations and extensive structure-activityrelationship determinations, the Canadian group has found a lead molecule thatlooks very promising. It "can mop it all up," says Weaver. He cautions,however, that any human application is at leas...Neurotransmitter-Induced Electrical Activity Identified As Key Regulator Of Synaptogenesis
... formation. These similarities in the molecular events underlying learning and memory and those operating during synaptogenesis are consistent with studies showing that experience modifies neuronal circuitries both during development and in adulthood....Scientists Create Extremely Sensitive Test For Detecting Radiation Damage
...arious fields of life sciences, from toxicology to molecular biology,"according to an accompanying editorial in Science. "Armed with such a specific and sensitive assay, one can only begin toimagine some of the possibilities," the editorial writer said. "For instance,scientists should more easily detec...Polish Dumpling-Like Particle Has Potential In Drug Delivery
...ins to stick and denature, which is an altering of molecular structure. As for that name: After Wooley and her group constructed the polymer particles, they tried to see them with a standard electron microscope, but the particles were too small. They turned to colleague Tomasz Kowalewski, Ph.D., research ass...Drug's Effect On Chromosomes May Explain Second Cancers
... complication,” said Mark Muller,professor of molecular genetics and a researcher with Ohio State University’sComprehensive Cancer Center. “These results help us understand where the drug acts inside thecell, and they may help us understand why it causes secondary cancers insome patients.”...Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
...journal Science. The authors focus on the molecular signals that control food intake.The research review shows that the body has numerous integrated and redundantsystems for regulating weight, and that many pathways in the central nervoussystem participate in responding to signals informing the brain ...... animal models, in patients with depression, andby molecular biological examinations that the negative feed back loop of the HPAaxis is altered and that cortisol is unable to suppress CRH secretion. Theelevated CRH level is probably responsible for the symptoms of depression. Asnow published in Nature Genetic...