Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...ion, it sends a signal that elicits some metabolic response to eliminatefat," Surwit said. Leptin travels through the bloodstream to the brain, where it targets clustersof neurons in the hypothalamus, a brain structure that regulates food intake and metabolism,among other functions. When leptin binds with r...AIDS Treatments Seek To Eradicate Virus, Restore Immunity
...virus and to immunity in these patients, and their response to the differenttherapeutic modalities." Working with Dr. George Shaw, a researcher from the University of Alabama,Greenberg will measure the levels of virus that exists in the plasma, bloodcells, and tissue before and during the therapies. ...New Colorectal Cancer Treatment Available
...ed at Memorial Sloan-Kettering showed a 32 percent response rate in 41 patients with colorectal cancer who had received no prior therapy. Dr. Saltz has recently reported the ability to give substantial doses of CPT-11 and standard chemotherapies together. "We are very encouraged by the anti-tumor activity of...Emory Doctors Discuss "Killing Heat" In This Week's NEJM
... levels." Based on their assessments of community response to the Chicago heat wave of 1995 and the Memphis, Tenn., heat wave of 1980, Dr. Kellermann and Dr. Todd make the following suggestions: "Since access to air-conditioning for even a few hours each day is protective, local governments in high-risk...Raising The Retirement Age In The United States Could Save Billions In Social Security Payments
...pulationmight be over age 65 by the year 2025. One response has been for older managersin Japan to continue working as senior consultants, but for fewer hourseach week, Manton said. Raising the normal retirement age in the United States could lead to otherchanges, Manton added. Workers could be encouraged to...Rape Victims Find Relief From Posttraumatic Stress Using The Antidepressant Zoloft.
...hat population. "There is a striking similarity of response to different trauma includingcombat, rape, accidents, and disasters," the authors write. "Many peoplerespond to a life threatening trauma with acute symptoms of posttraumaticstress disorder (PTSD) and a high percentage develop chronic PTSD. Thelifeti...ACTG 315 Preliminary Results: Drug Cocktail Restores Partial Immune Function
...s that it will give us real clues tohow the immune response recovers after therapy." ACTG 315 enrolled 53 men ...ppens in the course of disease itself in terms of response to therapy." Other related ACTG studies includeACTG 328, which is evaluating interleukin-2 plus HAAR...Laser Shown Effective In Patients Who Are Not Candidates For Bypass Surgery Or Angioplasty
...e new growth is somehow relatedto the inflammatory response to the creation of the channels. Once we figureout exactly how and why it works, we can then make it work better." Since it takes time for the new capillaries to grow, patients usuallydo not begin to see major improvements until three months a...Study Injects New Interest In How Vaccines Work
...e for months while the body produced antibodies in response to the antigens carried on its surface." The study...e has been used as an adjuvant to boost the immune response from vaccines. Currently, it is the only adjuvant approved by the Food and Drug Administration for u...Nasal Spray Flu Vaccine By U-M Researcher Is 93% Effective
...ry. The vaccine triggers an early, local antibody response in the nasalpassages---a powerful first line of defense and a key element in the preventionof influenza. School age children are major carriers of the disease. Influenzakills 20,000 people each year in the United States alone. The results o...New Approach To Multidrug Resistance
...are less vulnerable to damage than genesinduced in response to external signals -- such as hormone fluctuations or anincursion of foreign chemicals. Because the gene for P-glycoprotein isinducible, activated by cues from its environment, investigators were interestedin how it would be affected by cancer chem...New Ultrasound Technique Is Alternative To Cerebral Angiography
... send pieces into thebrain, or trigger an arterial response that may form blood clots, leavingpatients at risk of stroke not only during the procedure but for several hoursafterward. And, said Hirsch, "the risk is exponential depending on their age andtheir history of stroke." Hirsch and other studied...Studies Find Public Policies For Children And Teenagers Not Very Effective
...TV content more educational forchildren." In response to the study, the FCC has recently tightened itsdefinition of educational programming and established a three-hour-per-week requirement that will take effect later this year....New Test May Improve Treatment Of Kidney Disease
... or laboratorytechniques for estimating afavorable response to treatment. Although our work is preliminary, furtherrefinement of thistechnique might contribute to improved treatment results." The award-winning article describes how researchers studied 16 patientswith various diseasesof the glomerulus, a...Common Drug-Capsule Coating Not As Inert As Previously Thought
...otein structures and trigger an unwantedbiological response that would lead to rejection." One of the current problems in the design of biomaterials is that thereis no direct correlation between a material's properties and its biocompatibility,Leckband said. "Because of its apparent low toxicity and apparen...... Phase I trial, three othersalso showed a positive response to the aminopterin: an 8-year-old boy with anerve-sheath tumor, a 10-year-old boy with acute-myelogenous leukemia (AML) anda 4-year-old girl with a neuroectodermal tumor. Kamen presented his findings to the American Society for ClinicalOncol...NIH Honors Emory Researcher With Merit Award For Work On Renin-Angiotensin System
...sages from the cell surface to thecell nucleus. In response to angiotensin II, the AT1 receptor activates anintracellular messenger called the Jak2 kinase, which in turn initiates acascade of signals often referred to as the Jak-STAT pathway. Through thiscascading pathway, messages are sent from the cell surf......er, and the population as a whole. Alower level of response combined with a wide range of estimates indicate "theuncertainty of what the future may bring," the initial report said. A final survey analysis is expected early in 1998. The preliminaryreport was authored by Marjorie Rosenberg, Fellow, Soc......ative American health services. Effective response to these powerful forces will require greatermanagement sophistication in Native American health systems. In a surveyconducted in 1997 of 85 leaders of Native American health care at 33 clinicsites, respondents cited their major challenges as follows......blood cells were present, "indicating a suboptimal response toaspirin." Sixteen percent had clumping even though the red blood cells were notpresent. "This latter group may be more thrombosis-prone than the otherparticipants," says Marcus. In 39 percent of individuals, aspirin...