DNA Imaging to Design Better Drugs
...ed a new way to examine andquickly map how nucleic acid ligands, in some cases anti-cancer drugs,bind to and alter DNA at the molecular level. This new method works by imaging individual DNA molecules. It'sfaster than traditional methods, and the results are direct andrelatively simple to interpret. "Ou...Duke Obtains FDA Designation For Pompe Disease Therapy
...ion caused by an inherited deficiencyof the enzyme acid alpha glucosidase. Acid alpha glucosidase normally degradescellular stores of glycogen into glucose, a primary energy source. Patientssuffering from Pompe disease lack sufficient enzyme for that chemical conversion.As a result, glycogen accumulates a...X-ray Microscope Designed To Study Jet Engine Components Now Probes Tooth Dentin
...prepare a tooth for bonding a filling, they use an acid todemineralize the surface of the cavity. This pr...solution image in anyenvironment, including wet or acid solutions. As a result, the UCSF researcherswere the among the first to describe why the polymer bo...Fat: It's Not For Breakfast Anymore; Study Finds Fat Linked To Clotting
...from fat, were tested. The diets differed infatty acid composition. One had palmitic acid (a highly saturated fat found inanimals); one had stearic acid (found in beef and cocoa butter) and ...Neurotransmitter-Induced Electrical Activity Identified As Key Regulator Of Synaptogenesis
...nducing the aggregation of receptors for the amino acid glycine, the major inhibitory neurotransmitter in the spinal cord. Already in 1993, these scientists had reported (also in "nature") that the accumulation of the glycine receptor-associated cytoplasmic protein ...Emerging Pathogens And Safety Of Fresh Produce Key Issues Facing Food IndustryAnd Scientists
... cayetanensis and C. parvum, and thosethat acquire acid resistance. Through the natural selection process, the latterincrease their survival in acidic foods, decrease their inactivation in thestomach, and increase their virulence. Strains often associated with foodborneoutbreaks, such as Escherichia col...Compound In Meat Prevents Diabetes, Study Suggests
...study found that conjugated linoleic acid, a fatty acid known to scientists as "CLA," can prevent the onset of diabetes in laboratory animals, at least in the short term. The researchers say CLA appears to work as well as a new class of diabetes-fighting drugs, the thiazolidinediones, or TZDs. Martha Belu...18 Millionth Chemical Substance Entered In World's Largest Database Of ChemicalInformation
...me is (1S-cis)-2-Phenyl-3-cyclohexene-1-carboxylic acid and itis identified by the CAS Registry Number 207110-49-4. Chemical Abstracts Service reviews and summarizes chemistry research in patents,conference proceedings and more than 8,000 scientific journals; in the process,CAS scientists identify new che......receptor present in the liver andinvolved in fatty acid breakdown . PPARa acts as a messenger, allowing the bodyto adapt to its nutritional environment (especially ingestion of large amountsof fat). Fibrates, synthetic compounds that bind to this receptor, stimulatePPARa activity and thereby reinforce its...Encapsulating Insulin-Producing Cells For Possible Diabetes Therapy
...ht to "photo cross-link" viscous liquid hyaluronic acid so that itsmolecular chains mesh together into solid gels. Meanwhile, Hatchell faces her own set of medical challenges inextracting the islet cells for transplantation. "We have to use a very harshenzyme called collagenase to dissolve the con...Vinegar Offers Dependable Test For Cervical Cancer
...e-midwives who wiped a patient's cervix withacetic acid (vinegar) and then visually inspected the area accurately detectedmore than 75 percent of potential cancers among the study participants. Tissueharboring precancerous lesions turns white when exposed to vinegar. The testidentified almost twice as m...Chemists Discover That Aerosol Clusters Play Larger Role In Generation Of Air Pollution
...so quickly and repeatedly. The result was nitrous acid and methyl nitrite, a known carcinogen. "Our work...xide reacting withan organic molecule to create an acid and a reactive carcinogen." He noted that while atmospheric reactions of nitric oxide with oxygen an...Postmenopausal Women Reap Heart Benefits From Foods Containing Vitamin E
...en the intake of vitaminC, beta-carotene and folic acid -- from both food and supplements -- and LDLoxidation. None of these nutrients protected against oxidation. "The reason may be because these nutrients may not be as good of an antioxidantas vitamin E. Also, the majority of women in this study who w...News About Osteoporosis: Fruits And Vegetables Prevent Bone Decay
...lkaline environment in the bodythey neutralize the acid without depending on thebuffering effects of the bone minerals. It is also possible that potassium and magnesium have direct effects on bone cells." People who consume a lot of highly processed foods often lack adequate amounts of potassium and magne...Study Suggests Inflammation Signs Can Show Who Will Develop Diabetes
...dy's inflammatory response--orosomucoid and sialic acid -- faced even higher risks of developing thecondit... by the liver following inflammatorystress. Sialic acid is a carbohydrate attached to a series of proteins made bythe liver in reaction to such stress. ...Ph.D. Degree Research Results In Patent For Low-Cost Pharmaceutical Filters Made From Seafood Waste
...t can be dissolved in mixtures of water and acetic acid --essentially strong vinegar," says Todd. "It's a much more user-friendlysolvent." Chitosan also has other properties that give chitosan beads certainadvantages over cellulose beads, including greater ease of attachment ofligands. Todd was looking fo...Researchers discover treatment that delays onset of insulin-dependent diabetes
...cted cells, in particular a protein named glutamic acid decarboxylase orGAD, from the immune system could prevent the immunological process that causesdiabetes. Dr. Kim and his research group produced a naturally-occurring blocking agent orprotein that is an antibody to GAD. The researchers tested the bl...(Neural tube defects and periconceptional folic acid in England and Wales: retrospective study) (Co...folic acid) Foods should be fortified with folic acid to ensure that women considering trying for a baby receive the recommended levels of this important ...New studies of a liquid of life -- Lung surfactant
...emented with synthetic lipids, typically palmitic acid and DPPC), synthetic formulations modeled on natural lung surfactant, and, synthetic formulations with no relation to natural lung surfactant. "Natural lung surfactant extracts have been shown to be effective bothin vitro and in v......cid, is converted into the form of dehydroascorbic acid andtransported into the cell. Once inside, the vit...C by a process involving the conversionof ascorbic acid to dehydroascorbic acid. "Now we know that tumors acquire and retain large amounts of vitamin C. S...