Maternal Exposure To Crack Cocaine Produces Stressed Newborns
...rchers think the findings result from the combined action ofcocaine with alcohol and marijuana. Alcohol can boost the effects of cocaine,and most of the crack-smoking women in the study abused alcohol andmarijuana. The Brown study injects clear-cut evidence into a two-decade-old medicaldebate over what happ...Discovery Hints At Multitude Of New Targets For Drugs
... When a hormoneor drug plugs into a receptor, that action changes the shape, or conformation,of the receptor...bring the nextwave in the understanding of hormone action and drug development." McDonnell uses a geometric analogy to explain how a single kind of s...Raising The Retirement Age In The United States Could Save Billions In Social Security Payments
...retirementage are forthcoming. Based on government action taken in 1983, the normalretirement age would begin to rise to 67 after the turn of the century.In addition, the Kerry-Danforth commission has studied a proposal that wouldhike the retirement age to 70, and Manton said he's even heard talk of raising...Common Carbohydrates May Prove To Be Substitute For Dietary Fiber
... contains anti-inflammatory fattyacids, protective action was increased even more. Fahey suggests that peoplehospitalized with bowel disease might benefit from their results. In a third study, yet to be published, Fahey's lab will report that artichoke,chicory, onion, garlic, leek, shallot, chives and aspa...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...ng events using synthetic molecules is thebasis of action of almost all pharmaceutical compounds, Toone said... do. But in the process the drugs blockthe natural action of the protein. Toone said a "holy grail" of pharmaceutical chemistry -- theso-called "rationa...Ultrasound Helps Pediatric Heart Surgeons After Open Heart Surgery
... been in removing air from theheart and if further action is needed. "Our investigation basically re...monitoring the patient, it helps them determine if action is needed,such as drugs, to protect the brain, and they don't have to wait until the endof the surge...Antioxidant-Enhancing Drug Partly Rescues Noise-Induced Hearing Loss
...ts of their most recent study, which describes the action of R-PIAin an animal model, will be presented on F...r of communicative disorders andsciences, said the action of R-PIA likely would be similar in the human ear. "In the future, we may be able to rescu...Targon And Duke Cancer Center Sign $3.75 Million Agreement To Produce Advanced Anti-Cancer Drugs
...wer deleterious effects on patients. Such pinpoint action means that clinical testing of new drugs requires morespecific measures of performance. "For example, Duke researchers will work to develop `surrogate markers' for more precise testing of new drugs. Since traditional anti-tumor drugs kill tum......reduce blood pressure. However, this vasodilator action may force the heart topump harder and may also stimulate stress hormones. This action is the oppositeof beta-blockers that limit cardiac output, notes Izzo, professor of medicineand phar...... been developing prototype painkillers toblock the action of substance P and neurokinin A on receptors located on thesurfaces of pain-transmitting nerve cells. The recent rodent studies by Basbaumand others are defining and refining scientific understanding of the rolesplayed by these and other molecules i...Earliest Warning Sign Indicates Need To Test For Condition Associated With Fetal Deaths
... finding suggests that it would be prudent to take action to confirm the diagnosis and begin treatment if necessary, based on one indicator," Gugino said. "The likelihood is great that chorioamnionitis is present." Additional investigators on the study were Paul T. Buerger, M.D.; Jean Wactawski-Wende, ......e rare in both groups. The mechanism of suramin's action is complex, said Small, and still has not beenfully delineated. Prostate cancer, the most common cancer in men, accounted for more than 40,000deaths in the United States in 1997. Approximately 300,000 American men arediagnosed with the disease each...American Heart Association Comment: Tirofiban -- The Platelet Receptor Blocker For Heart Attack
...kers." As the name suggests, the drug blocks the action of platelets,cells that clump to help form a blood clot. The drugs have been used to improve the results of angioplasty -- a bloodvessel-opening procedure -- by preventing reclosure of blood vessels, a commonproblem. But last week the Food and Drug...Drug's Effect On Chromosomes May Explain Second Cancers
...ase-IIinhibitors. These drugs work by blocking the action of an enzyme found incells known as topoisomerase II (topo II). The job of topo II is to untangleDNA strands during cell division; failure to do so is lethal to the cell. Topo II does this by making temporary breaks in DNA to allow anotherDNA strand...Synthetic Detergent Found To Fight Multi-Drug Resistance
... chemical isprobably too low to interfere with the action of the drug pump it might be auseful adjunct to standard chemotherapy treatments, along with other relativelynon-toxic detergents." "Detergents are composed of compounds that can be chemically synthesizedto suit your needs," says Charuk. "Wi...... Laboratory findings and theoreticalmechanisms of action were reviewed in March 1997, epidemiology findings inJanuary 1998, and in vivo and clinical studies in April 1998. The working group writing the advisory report will meet in publicsessions June 16-24 to discuss the research that has been do...States Must Be Held Accountable For New Health Plans For Children
...mprove accountability in healthcare. The time for action is now, while these new plans are being established." The five-year insurance expansion was passed as part of the Balanced Budget Actof 1997. It allocates $20.3 billion for states to use in expanding privateinsurance for children and another $3.6 bi...... The long-sought crystal structure of gp120 in action is a collaborativeeffort led by researchers from the Columbia University College of Physicians &Surgeons, and the Dana-Farber Cancer Institute. "The crystal structure tells ushow the virus is able to bind to the receptor at the same time that it rem......ker of vascularcell inflammation. The mechanism of action of these PPARa receptors in the vascular wall was ...NFkB transcription pathway. This anti-inflammatory action of the fibrates has been confirmed in humans. Theresearchers compared two groups of 19 patients with......rial world prices, according to Marseille. "This action opens the way for large-scale drug interventions because we nowknow that these therapies can make both medical and economic sense," he said.In previous studies in the U.S., the AIDS Clinical Trial Group of the NationalInstitutes of Health found treat...